6YIO

CRYSTAL STRUCTURE OF FAB RG6292 IN COMPLEX WITH CD25 ECD

Summary for 6YIO

Entry DOI	10.2210/pdb6yio/pdb
Descriptor	Interleukin-2 receptor subunit alpha, FAB FRAGMENT HEAVY CHAIN, FAB FRGAMENT LIGHT CHAIN, ... (4 entities in total)
Functional Keywords	antibody, cd25 ecd, fab rg6292, il2ra, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	70263.51
Authors	Benz, J.,Koll, H.,Leibrock, L. (deposition date: 2020-04-01, release date: 2020-11-11, Last modification date: 2024-01-24)
Primary citation	Solomon, I.,Amann, M.,Goubier, A.,Vargas, F.A.,Zervas, D.,Qing, C.,Henry, J.Y.,Ghorani, E.,Akarca, A.U.,Marafioti, T.,Sledzinska, A.,Sunderland, M.W.,Demane, D.F.,Clancy, J.R.,Georgiou, A.,Salimu, J.,Merchiers, P.,Brown, M.A.,Flury, R.,Eckmann, J.,Murgia, C.,Sam, J.,Jacobsen, B.,Marrer-Berger, E.,Boetsch, C.,Belli, S.,Leibrock, L.,Benz, J.,Koll, H.,Sutmuller, R.,Peggs, K.S.,Quezada, S.A. CD25-T reg -depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity. Nat Cancer, 1:1153-1166, 2020 Cited by PubMed: 33644766 DOI: 10.1038/s43018-020-00133-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation