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3GP0
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CRYSTAL STRUCTURE OF HUMAN MITOGEN ACTIVATED PROTEIN KINASE 11 (P38 BETA) IN COMPLEX WITH NILOTINIB
Descriptor:Mitogen-activated protein kinase 11, Nilotinib, 1,2-ETHANEDIOL, ...
Authors:Filippakopoulos, P., Barr, A., Fedorov, O., Keates, T., Soundararajan, M., Elkins, J., Salah, E., Burgess-Brown, N., Ugochukwu, E., Pike, A.C.W., Muniz, J., Roos, A., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-03-20
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 beta) in complex with Nilotinib
To be Published
3GVU
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THE CRYSTAL STRUCTURE OF HUMAN ABL2 IN COMPLEX WITH GLEEVEC
Descriptor:Tyrosine-protein kinase ABL2, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
Authors:Ugochukwu, E., Salah, E., Barr, A., Mahajan, P., Shrestha, B., Savitsky, P., Chaikuad, A., Filippakopoulos, P., Roos, A., Pike, A.C.W., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-03-31
Release date:2009-04-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The crystal structure of human ABL2 in complex with GLEEVEC
To be Published
3HMI
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THE CRYSTAL STRUCTURE OF HUMAN ABL2 IN COMPLEX WITH 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Descriptor:Tyrosine-protein kinase ABL2, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Authors:Ugochukwu, E., Salah, E., Barr, A., Mahajan, P., Shrestha, B., Savitsky, P., Chaikuad, A., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-05-29
Release date:2009-07-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
To be Published
3OP3
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CRYSTAL STRUCTURE OF CELL DIVISION CYCLE 25C PROTEIN ISOFORM A FROM HOMO SAPIENS
Descriptor:M-phase inducer phosphatase 3, SULFATE ION
Authors:Kim, Y., Weger, A., Hatzos, C., Savitsky, P., Johansson, C., Ball, L., Barr, A., Vollmar, M., Muniz, J., Weigelt, J., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O., von Delft, F., Knapp, S., Joachimiak, A., Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-09-29
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Crystal Structure of Cell Division Cycle 25C Protein Isoform A from Homo sapiens
TO BE PUBLISHED
2PQ5
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CRYSTAL STRUCTURE OF DUAL SPECIFICITY PROTEIN PHOSPHATASE 13 (DUSP13)
Descriptor:Dual specificity protein phosphatase 13
Authors:Ugochukwu, E., Salah, E., Savitsky, P., Barr, A., Pantic, N., Niesen, F., Burgess-Brown, N., Berridge, G., Bunkoczi, G., Uppenberg, J., Pike, A.C.W., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-05-01
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of Dual specificity protein phosphatase 13 (DUSP13).
To be Published
2VSW
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THE STRUCTURE OF THE RHODANESE DOMAIN OF THE HUMAN DUAL SPECIFICITY PHOSPHATASE 16
Descriptor:DUAL SPECIFICITY PROTEIN PHOSPHATASE 16
Authors:Murray, J.W., Barr, A., Pike, A.C.W., Elkins, J., Phillips, C., Wang, J., Savitsky, P., Roos, A., Bishop, S., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Burgess-Brown, N., Pantic, N., Bray, J., von Delft, F., Gileadi, O., Knapp, S.
Deposit date:2008-04-30
Release date:2008-07-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structure of the Rhodanese Domain of the Human Dual Specifity Phosphatase 16
To be Published
4DYL
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F-BAR DOMAIN OF HUMAN FES TYROSINE KINASE
Descriptor:Tyrosine-protein kinase Fes/Fps
Authors:Ugochukwu, E., Salah, E., Elkins, J., Barr, A., Krojer, T., Filippakopoulos, P., Weigelt, J., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2012-02-29
Release date:2012-04-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:F-BAR domain of human FES tyrosine kinase
TO BE PUBLISHED
5OCH
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THE CRYSTAL STRUCTURE OF HUMAN ABCB8 IN AN OUTWARD-FACING STATE
Descriptor:ATP-binding cassette sub-family B member 8, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Faust, B., Pike, A.C.W., Shintre, C.A., Quiqley, A.M., Chu, A., Barr, A., Shrestha, L., Mukhopadhyay, S., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The crystal structure of human ABCB8 in an outward-facing state
To Be Published
3FME
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CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (MEK6) ACTIVATED MUTANT (S207D, T211D)
Descriptor:Dual specificity mitogen-activated protein kinase kinase 6, STAUROSPORINE
Authors:Filippakopoulos, P., Barr, A., Pike, A.C.W., Berridge, G., Elkins, J., Fedorov, O., Keates, T., Savitsky, P., Soundararajan, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-12-21
Release date:2009-01-06
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated Mutant (S207D, T211D)
To be Published
2GJT
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CRYSTAL STRUCTURE OF THE HUMAN RECEPTOR PHOSPHATASE PTPRO
Descriptor:Receptor-type tyrosine-protein phosphatase PTPRO, CHLORIDE ION
Authors:Barr, A., Ugochukwu, E., Eswaran, J., Das, S., Niesen, F., Savitsky, P., Turnbull, A., Sundstrom, M., Arrowsmith, C., Edwards, A., Weigelt, J., von Delft, F., Papagrigoriou, E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-03-31
Release date:2006-05-02
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2A3K
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE, PTPN7 (HEPTP, HEMATOPOIETIC PROTEIN TYROSINE PHOSPHATASE)
Descriptor:protein tyrosine phosphatase, non-receptor type 7, isoform 1, ...
Authors:Barr, A., Turnbull, A.P., Das, S., Eswaran, J., Debreczeni, J.E., Longmann, E., Smee, C., Burgess, N., Gileadi, O., Sundstrom, M., Arrowsmith, C., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-06-24
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Protein Sci., 15, 2006
2A8B
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYROSINE PHOSPHATASE RECEPTOR, TYPE R
Descriptor:Receptor-type tyrosine-protein phosphatase R, CHLORIDE ION
Authors:Ugochukwu, E., Eswaran, J., Barr, A., Longman, E., Arrowsmith, C., Edwards, A., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-07-07
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem.J., 395, 2006
2AHS
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYROSINE RECEPTOR PHOSPHATASE BETA
Descriptor:Receptor-type tyrosine-protein phosphatase beta, CHLORIDE ION, SODIUM ION, ...
Authors:Ugochukwu, E., Eswaran, J., Barr, A., Gileadi, O., Sobott, F., Burgess, N., Ball, L., Bray, J., von Delft, F., Debreczeni, J., Bunkoczi, G., Turnbull, A., Das, S., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-07-28
Release date:2005-08-09
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2B49
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 3
Descriptor:protein tyrosine phosphatase, non-receptor type 3
Authors:Ugochukwu, E., Arrowsmith, C., Barr, A., Bunkoczi, G., Das, S., Debreczeni, J., Edwards, A., Eswaran, J., Knapp, S., Sundstrom, M., Turnbull, A., von Delft, F., Weigelt, J., Structural Genomics Consortium (SGC)
Deposit date:2005-09-23
Release date:2005-10-04
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2I75
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CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE N4 (PTPN4)
Descriptor:Tyrosine-protein phosphatase non-receptor type 4, SULFATE ION
Authors:Ugochukwu, E., Barr, A., Savitsky, P., Burgess, N., Das, S., Turnbull, A., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-08-30
Release date:2006-10-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2OC3
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PROTEIN TYROSINE PHOSPHATASE NON-RECEPTOR TYPE 18
Descriptor:Tyrosine-protein phosphatase non-receptor type 18
Authors:Ugochukwu, E., Barr, A., Alfano, I., Gorrec, F., Umeano, C., Savitsky, P., Sobott, F., Eswaran, J., Papagrigoriou, E., Debreczeni, J.E., Turnbull, A., Bunkoczi, G., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-12-20
Release date:2007-01-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2P6X
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CRYSTAL STRUCTURE OF HUMAN TYROSINE PHOSPHATASE PTPN22
Descriptor:Tyrosine-protein phosphatase non-receptor type 22, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Ugochukwu, E., Salah, E., Barr, A., Shrestha, L., Alfano, I., Burgess-Brown, N., King, O., Umeano, C., Papagrigoriou, E., Pike, A.C.W., Bunkoczi, G., Turnbull, A., Uppenberg, J., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-03-19
Release date:2007-04-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2PA5
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CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN9
Descriptor:Tyrosine-protein phosphatase non-receptor type 9, CHLORIDE ION, THIOCYANATE ION, ...
Authors:Ugochukwu, E., Barr, A., Pike, A.C.W., Savitsky, P., Papagrigoriou, E., Turnbull, A., Uppenberg, J., Bunkoczi, G., Salah, E., Das, S., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-03-27
Release date:2007-05-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2BZL
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE N14 AT 1. 65 A RESOLUTION
Descriptor:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 14, SULFATE ION, ...
Authors:Debreczeni, J.E., Barr, A., Eswaran, J., Das, S., Burgess, N., Longman, E., Fedorov, O., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Knapp, S.
Deposit date:2005-08-18
Release date:2005-09-13
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of Human Protein Tyrosine Phosphatase 14 (Ptpn14) at 1.65-A Resolution.
Proteins, 63, 2006
2C7S
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CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE KAPPA AT 1.95A RESOLUTION
Descriptor:RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE KAPPA, ACETATE ION
Authors:Debreczeni, J.E., Ugochukwu, E., Eswaran, J., Barr, A., Das, S., Burgess, N., Gileadi, O., Longman, E., von Delft, F., Knapp, S., Sundstron, M., Arrowsmith, C., Weigelt, J., Edwards, A.
Deposit date:2005-11-28
Release date:2007-01-02
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Protein Sci., 15, 2006
2H4V
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CRYSTAL STRUCTURE OF THE HUMAN TYROSINE RECEPTOR PHOSPHATASE GAMMA
Descriptor:Receptor-type tyrosine-protein phosphatase gamma, CHLORIDE ION, CITRATE ANION, ...
Authors:Ugochukwu, E., Barr, A., Das, S., Eswaran, J., Savitsky, P., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Debreczeni, J., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-05-25
Release date:2006-07-11
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2NZ6
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CRYSTAL STRUCTURE OF THE PTPRJ INACTIVATING MUTANT C1239S
Descriptor:Receptor-type tyrosine-protein phosphatase eta, NICKEL (II) ION, PHOSPHATE ION, ...
Authors:Ugochukwu, E., Barr, A., Savitsky, P., Pike, A.C.W., Bunkoczi, G., Sundstrom, M., Weigelt, J., Arrowsmith, C.H., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-11-22
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2OOQ
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CRYSTAL STRUCTURE OF THE HUMAN RECEPTOR PHOSPHATASE PTPRT
Descriptor:Receptor-type tyrosine-protein phosphatase T, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SODIUM ION, ...
Authors:Ugochukwu, E., Alfano, I., Barr, A., Keates, T., Eswaran, J., Salah, E., Savitsky, P., Bunkoczi, G., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-01-26
Release date:2007-02-20
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2QEP
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CRYSTAL STRUCTURE OF THE D1 DOMAIN OF PTPRN2 (IA2BETA)
Descriptor:Receptor-type tyrosine-protein phosphatase N2, CHLORIDE ION
Authors:Ugochukwu, E., Barr, A., Alfano, I., Berridge, G., Burgess-Brown, N., Das, S., Fedorov, O., King, O., Niesen, F., Watt, S., Savitsky, P., Salah, E., Pike, A.C.W., Bunkoczi, G., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-06-26
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
3B7O
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CRYSTAL STRUCTURE OF THE HUMAN TYROSINE PHOSPHATASE SHP2 (PTPN11) WITH AN ACCESSIBLE ACTIVE SITE
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, D-MALATE
Authors:Ugochukwu, E., Barr, A., Patel, A., King, O., Niesen, F., Salah, E., Savitsky, P., Pilka, E.S., Elkins, J., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-13
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
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