1C3M

CRYSTAL STRUCTURE OF HELTUBA COMPLEXED TO MAN(1-3)MAN

Summary for 1C3M

Entry DOI	10.2210/pdb1c3m/pdb
Related PRD ID	PRD_900112
Descriptor	AGGLUTININ, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose (3 entities in total)
Functional Keywords	agglutinin, jacalin-related, beta-prism, mannose, sugar binding protein
Biological source	Helianthus tuberosus
Total number of polymer chains	1
Total formula weight	15843.77
Authors	Bourne, Y.,Zamboni, V.,Barre, A.,Peumans, W.J.,van Damme, E.J.M.,Rouge, P. (deposition date: 1999-07-28, release date: 2000-01-10, Last modification date: 2024-02-07)
Primary citation	Bourne, Y.,Zamboni, V.,Barre, A.,Peumans, W.J.,Van Damme, E.J.,Rouge, P. Helianthus tuberosus lectin reveals a widespread scaffold for mannose-binding lectins. Structure Fold.Des., 7:1473-1482, 1999 Cited by PubMed Abstract: Heltuba, a tuber lectin from the Jerusalem artichoke Helianthus tuberosus, belongs to the mannose-binding subgroup of the family of jacalin-related plant lectins. Heltuba is highly specific for the disaccharides Man alpha 1-3Man or Man alpha 1-2Man, two carbohydrates that are particularly abundant in the glycoconjugates exposed on the surface of viruses, bacteria and fungi, and on the epithelial cells along the gastrointestinal tract of lower animals. Heltuba is therefore a good candidate as a defense protein against plant pathogens or predators. PubMed: 10647178 DOI: 10.1016/S0969-2126(00)88338-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation