1C3K

CRYSTAL STRUCTURE OF HELIANTHUS TUBEROSUS LECTIN

Summary for 1C3K

• Entry DOI: 10.2210/pdb1c3k/pdb
• Descriptor: AGGLUTININ (2 entities in total)
• Functional Keywords: beta prism, agglutinin, jacalin-related, mannose, sugar binding protein
• Biological source: Helianthus tuberosus
• Total number of polymer chains: 1
• Total formula weight: 15501.47

Authors

Bourne, Y.,Zamboni, V.,Barre, A.,Peumans, W.J.,van Damme, E.J.M.,Rouge, P. (deposition date: 1999-07-28, release date: 2000-01-10, Last modification date: 2024-02-07)

Primary citation

Bourne, Y.,Zamboni, V.,Barre, A.,Peumans, W.J.,Van Damme, E.J.,Rouge, P.
Helianthus tuberosus lectin reveals a widespread scaffold for mannose-binding lectins.
Structure Fold.Des., 7:1473-1482, 1999

PubMed Abstract: Heltuba, a tuber lectin from the Jerusalem artichoke Helianthus tuberosus, belongs to the mannose-binding subgroup of the family of jacalin-related plant lectins. Heltuba is highly specific for the disaccharides Man alpha 1-3Man or Man alpha 1-2Man, two carbohydrates that are particularly abundant in the glycoconjugates exposed on the surface of viruses, bacteria and fungi, and on the epithelial cells along the gastrointestinal tract of lower animals. Heltuba is therefore a good candidate as a defense protein against plant pathogens or predators.

PubMed: 10647178
DOI: 10.1016/S0969-2126(00)88338-0

Experimental method

X-RAY DIFFRACTION (2 Å)