Author results

1ZFL
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SOLUTION STRUCTURE OF III-A, THE MAJOR INTERMEDIATE IN THE OXIDATIVE FOLDING OF LEECH CARBOXYPEPTIDASE INHIBITOR
Descriptor:Metallocarboxypeptidase inhibitor
Authors:Arolas, J.L., D'Silva, L., Popowicz, G.M., Aviles, F.X., Holak, T.A., Ventura, S.
Deposit date:2005-04-20
Release date:2005-09-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005
1ZLH
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CRYSTAL STRUCTURE OF THE TICK CARBOXYPEPTIDASE INHIBITOR IN COMPLEX WITH BOVINE CARBOXYPEPTIDASE A
Descriptor:Carboxypeptidase A1, carboxypeptidase inhibitor, ZINC ION
Authors:Arolas, J.L., Popowicz, G.M., Lorenzo, J., Sommerhoff, C.P., Huber, R., Aviles, F.X., Holak, T.A.
Deposit date:2005-05-06
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode
J.Mol.Biol., 350, 2005
1ZLI
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CRYSTAL STRUCTURE OF THE TICK CARBOXYPEPTIDASE INHIBITOR IN COMPLEX WITH HUMAN CARBOXYPEPTIDASE B
Descriptor:Carboxypeptidase B, carboxypeptidase inhibitor, ZINC ION
Authors:Arolas, J.L., Popowicz, G.M., Lorenzo, J., Sommerhoff, C.P., Huber, R., Aviles, F.X., Holak, T.A.
Deposit date:2005-05-06
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode
J.Mol.Biol., 350, 2005
2ABZ
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CRYSTAL STRUCTURE OF C19A/C43A MUTANT OF LEECH CARBOXYPEPTIDASE INHIBITOR IN COMPLEX WITH BOVINE CARBOXYPEPTIDASE A
Descriptor:Carboxypeptidase A1, Metallocarboxypeptidase inhibitor, ZINC ION
Authors:Arolas, J.L., Popowicz, G.M., Bronsoms, S., Aviles, F.X., Huber, R., Holak, T.A., Ventura, S.
Deposit date:2005-07-18
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond
J.Mol.Biol., 352, 2005
1ZFI
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SOLUTION STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR
Descriptor:Metallocarboxypeptidase inhibitor
Authors:Arolas, J.L., D'Silva, L., Popowicz, G.M., Aviles, F.X., Holak, T.A., Ventura, S.
Deposit date:2005-04-20
Release date:2005-09-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005
3SSB
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STRUCTURE OF INSECT METALLOPROTEINASE INHIBITOR IN COMPLEX WITH THERMOLYSIN
Descriptor:Thermolysin, Inducible metalloproteinase inhibitor protein, GLYCEROL, ...
Authors:Arolas, J.L., Botelho, T.O., Vilcinskas, A., Gomis-Ruth, F.X.
Deposit date:2011-07-08
Release date:2011-09-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural evidence for standard-mechanism inhibition in metallopeptidases from a complex poised to resynthesize a Peptide bond.
Angew.Chem.Int.Ed.Engl., 50, 2011
4GWM
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CRYSTAL STRUCTURE OF HUMAN PROMEPRIN BETA
Descriptor:Meprin A subunit beta, ZINC ION, SODIUM ION, ...
Authors:Arolas, J.L., Broder, C., Jefferson, T., Guevara, T., Sterchi, E.E., Bode, W., Stocker, W., Becker-Pauly, C., Gomis-Ruth, F.X.
Deposit date:2012-09-03
Release date:2012-09-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane
Proc.Natl.Acad.Sci.USA, 109, 2012
4GWN
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CRYSTAL STRUCTURE OF HUMAN MATURE MEPRIN BETA
Descriptor:Meprin A subunit beta, CADMIUM ION, SODIUM ION, ...
Authors:Arolas, J.L., Broder, C., Jefferson, T., Guevara, T., Sterchi, E.E., Bode, W., Stocker, W., Becker-Pauly, C., Gomis-Ruth, F.X.
Deposit date:2012-09-03
Release date:2012-09-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane
Proc.Natl.Acad.Sci.USA, 109, 2012
4YU5
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CRYSTAL STRUCTURE OF SELENOMETHIONINE VARIANT OF BACILLUS ANTHRACIS IMMUNE INHIBITOR A2 PEPTIDASE ZYMOGEN
Descriptor:Immune inhibitor A, metalloprotease, ZINC ION, ...
Authors:Arolas, J.L., Goulas, T., Gomis-Ruth, F.X.
Deposit date:2015-03-18
Release date:2015-10-28
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome.
Structure, 24, 2016
4YU6
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CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS IMMUNE INHIBITOR A2 PEPTIDASE ZYMOGEN
Descriptor:Immune inhibitor A, metalloprotease, ZINC ION, ...
Authors:Arolas, J.L., Goulas, T., Gomis-Ruth, F.X.
Deposit date:2015-03-18
Release date:2015-10-28
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome.
Structure, 24, 2016
3OSL
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STRUCTURE OF BOVINE THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH TICK CARBOXYPEPTIDASE INHIBITOR
Descriptor:Carboxypeptidase B2, Carboxypeptidase inhibitor, ZINC ION
Authors:Valnickova, Z., Sanglas, L., Arolas, J.L., Petersen, S.V., Schar, C., Otzen, D., Aviles, F.X., Gomis-Ruth, F.X., Enghild, J.J.
Deposit date:2010-09-09
Release date:2010-09-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (6 Å)
Cite:Flexibility of the Thrombin-activatable Fibrinolysis Inhibitor Pro-domain Enables Productive Binding of Protein Substrates.
J.Biol.Chem., 285, 2010
2XS3
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STRUCTURE OF KARILYSIN CATALYTIC MMP DOMAIN
Descriptor:KARILYSIN PROTEASE, PEPTIDE ALA-PHE-THR-SER, ZINC ION, ...
Authors:Cerda-Costa, N., Guevara, T., Karim, A.Y., Ksiazek, M., Nguyen, K.-A., Arolas, J.L., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2010-09-24
Release date:2010-11-03
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of the Catalytic Domain of Tannerella Forsythia Karilysin Reveals It is a Bacterial Xenologue of Animal Matrix Metalloproteinases.
Mol.Microbiol., 79, 2011
2XS4
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STRUCTURE OF KARILYSIN CATALYTIC MMP DOMAIN IN COMPLEX WITH MAGNESIUM
Descriptor:KARILYSIN PROTEASE, PEPTIDE ALA-PHE-THR, MAGNESIUM ION, ...
Authors:Cerda-Costa, N., Guevara, T., Karim, A.Y., Ksiazek, M., Nguyen, K.-A., Arolas, J.L., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2010-09-24
Release date:2010-11-03
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Structure of the Catalytic Domain of Tannerella Forsythia Karilysin Reveals It is a Bacterial Xenologue of Animal Matrix Metalloproteinases.
Mol.Microbiol., 79, 2011
3D4U
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BOVINE THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR (TAFIA) IN COMPLEX WITH TICK-DERIVED CARBOXYPEPTIDASE INHIBITOR.
Descriptor:Carboxypeptidase B2, Carboxypeptidase inhibitor, ZINC ION, ...
Authors:Sanglas, L., Valnickova, Z., Arolas, J.L., Pallares, I., Guevara, T., Sola, M., Kristensen, T., Enghild, J.J., Aviles, F.X., Gomis-Ruth, F.X.
Deposit date:2008-05-15
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of activated thrombin-activatable fibrinolysis inhibitor, a molecular link between coagulation and fibrinolysis.
Mol.Cell, 31, 2008
3FJU
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ASCARIS SUUM CARBOXYPEPTIDASE INHIBITOR IN COMPLEX WITH HUMAN CARBOXYPEPTIDASE A1
Descriptor:Carboxypeptidase A1, Carboxypeptidase A inhibitor, ZINC ION, ...
Authors:Sanglas, L., Aviles, F.X., Huber, R., Gomis-Ruth, F.X., Arolas, J.L.
Deposit date:2008-12-15
Release date:2008-12-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite
Proc.Natl.Acad.Sci.USA, 106, 2009
3LMS
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STRUCTURE OF HUMAN ACTIVATED THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR, TAFIA, IN COMPLEX WITH TICK-DERIVED FUNNELIN INHIBITOR, TCI.
Descriptor:Carboxypeptidase B2, Carboxypeptidase inhibitor, ZINC ION, ...
Authors:Sanglas, L., Arolas, J.L., Valnickova, Z., Aviles, F.X., Enghild, J.J., Gomis-Ruth, F.X.
Deposit date:2010-02-01
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor
J.Thromb.Haemost., 8, 2010
3MN8
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STRUCTURE OF DROSOPHILA MELANOGASTER CARBOXYPEPTIDASE D ISOFORM 1B SHORT
Descriptor:LP15968p, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Tanco, S., Arolas, J.L., Guevara, T., Lorenzo, J., Aviles, F.X., Gomis-Ruth, F.X.
Deposit date:2010-04-21
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-Function Analysis of the Short Splicing Variant Carboxypeptidase Encoded by Drosophila melanogaster silver.
J.Mol.Biol., 401, 2010
3P24
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STRUCTURE OF PROFRAGILYSIN-3 FROM BACTEROIDES FRAGILIS
Descriptor:BFT-3, TETRAETHYLENE GLYCOL, GLYCEROL, ...
Authors:Goulas, T., Arolas, J.L., Gomis-Ruth, F.X.
Deposit date:2010-10-01
Release date:2010-12-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog.
Proc.Natl.Acad.Sci.USA, 108, 2011
4HE5
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CRYSTAL STRUCTURE OF THE SELENOMETHIONINE VARIANT OF THE C-TERMINAL DOMAIN OF GEOBACILLUS THERMOLEOVORANS PUTATIVE U32 PEPTIDASE
Descriptor:Peptidase family U32, SULFATE ION
Authors:Trillo-Muyo, S., Jasilionis, A., Domagalski, M.J., Chruszcz, M., Minor, W., Kuisiene, N., Arolas, J.L., Sola, M., Gomis-Ruth, F.X.
Deposit date:2012-10-03
Release date:2012-11-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Ultratight crystal packing of a 10 kDa protein.
Acta Crystallogr.,Sect.D, 69, 2013
4HE6
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF GEOBACILLUS THERMOLEOVORANS PUTATIVE U32 PEPTIDASE
Descriptor:Peptidase family U32, UNKNOWN ATOM OR ION, ACETATE ION
Authors:Trillo-Muyo, S., Jasilionis, A., Domagalski, M.J., Chruszcz, M., Minor, W., Kuisiene, N., Arolas, J.L., Sola, M., Gomis-Ruth, F.X.
Deposit date:2012-10-03
Release date:2012-11-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Ultratight crystal packing of a 10 kDa protein.
Acta Crystallogr.,Sect.D, 69, 2013
4HWX
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CRYSTAL STRUCTURE OF STREPTOMYCES CAESPITOSUS SERMETSTATIN
Descriptor:Neutral proteinase inhibitor ScNPI, GLYCEROL, ACETATE ION
Authors:Trillo-Muyo, S., Martinez-Rodriguez, S., Arolas, J.L., Gomis-Ruth, F.X.
Deposit date:2012-11-09
Release date:2012-12-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of action of a Janus-faced single-domain protein inhibitor simultaneously targeting two peptidase classes
CHEM SCI, 4, 2013
4HX2
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CRYSTAL STRUCTURE OF STREPTOMYCES CAESPITOSUS SERMETSTATIN IN COMPLEX WITH BACILLUS LICHENIFORMIS SUBTILISIN
Descriptor:KerA, Neutral proteinase inhibitor ScNPI, CALCIUM ION, ...
Authors:Trillo-Muyo, S., Martinez-Rodriguez, S., Arolas, J.L., Gomis-Ruth, F.X.
Deposit date:2012-11-09
Release date:2012-12-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Mechanism of action of a Janus-faced single-domain protein inhibitor simultaneously targeting two peptidase classes
CHEM SCI, 4, 2013
4HX3
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CRYSTAL STRUCTURE OF STREPTOMYCES CAESPITOSUS SERMETSTATIN IN COMPLEX WITH S. CAESPITOSUS SNAPALYSIN
Descriptor:Extracellular small neutral protease, Neutral proteinase inhibitor ScNPI, ZINC ION, ...
Authors:Trillo-Muyo, S., Martinez-Rodriguez, S., Arolas, J.L., Gomis-Ruth, F.X.
Deposit date:2012-11-09
Release date:2012-12-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of action of a Janus-faced single-domain protein inhibitor simultaneously targeting two peptidase classes
CHEM SCI, 4, 2013
4JIU
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CRYSTAL STRUCTURE OF THE METALLOPEPTIDASE ZYMOGEN OF PYROCOCCUS ABYSSI ABYLYSIN
Descriptor:Proabylysin, ZINC ION, GLYCEROL
Authors:Lopez-Pelegrin, M., Cerda-Costa, N., Martinez-Jimenez, F., Cintas-Pedrola, A., Canals, A., Peinado, J.R., Marti-Renom, M.A., Lopez-Otin, C., Arolas, J.L., Gomis-Ruth, F.X.
Deposit date:2013-03-07
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:A novel family of soluble minimal scaffolds provides structural insight into the catalytic domains of integral membrane metallopeptidases
J.Biol.Chem., 288, 2013
4JIX
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CRYSTAL STRUCTURE OF THE METALLOPEPTIDASE ZYMOGEN OF METHANOCALDOCOCCUS JANNASCHII JANNALYSIN
Descriptor:Projannalysin, ZINC ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Lopez-Pelegrin, M., Cerda-Costa, N., Martinez-Jimenez, F., Cintas-Pedrola, A., Canals, A., Peinado, J.R., Marti-Renom, M.A., Lopez-Otin, C., Arolas, J.L., Gomis-Ruth, F.X.
Deposit date:2013-03-07
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:A novel family of soluble minimal scaffolds provides structural insight into the catalytic domains of integral membrane metallopeptidases
J.Biol.Chem., 288, 2013
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