4GWN

Crystal structure of human mature meprin beta

Summary for 4GWN

• Entry DOI: 10.2210/pdb4gwn/pdb
• Related: 4GWM
• Descriptor: Meprin A subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: multidomain structure, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein: Q16820
• Total number of polymer chains: 1
• Total formula weight: 67819.65

Authors

Arolas, J.L.,Broder, C.,Jefferson, T.,Guevara, T.,Sterchi, E.E.,Bode, W.,Stocker, W.,Becker-Pauly, C.,Gomis-Ruth, F.X. (deposition date: 2012-09-03, release date: 2012-09-19, Last modification date: 2023-11-08)

• Primary citation: Arolas, J.L.,Broder, C.,Jefferson, T.,Guevara, T.,Sterchi, E.E.,Bode, W.,Stocker, W.,Becker-Pauly, C.,Gomis-Ruth, F.X.; Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane; Proc.Natl.Acad.Sci.USA, 109:16131-16136, 2012; PubMed: 22988105; DOI: 10.1073/pnas.1211076109

Experimental method

X-RAY DIFFRACTION (3 Å)