4GWN

Crystal structure of human mature meprin beta

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVQHEFLHAL

Chain	Residue	Details
A	THR149-LEU158

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site_id	PS00740
Number of Residues	41
Details	MAM_1 MAM domain signature. GfFMhfdSssvnvgatav.LesrtLypkrgfqCLqFyLynsG

Chain	Residue	Details
A	GLY309-GLY349

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01211

Chain	Residue	Details
A	GLU153

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01211, ECO:0000269|PubMed:22988105, ECO:0007744|PDB:4GWM

Chain	Residue	Details
A	HIS152
A	HIS156
A	HIS162

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Mediates preference for acidic residues at subsite P1'

Chain	Residue	Details
A	ARG238

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site_id	SWS_FT_FI4
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22988105

Chain	Residue	Details
A	ASN218
A	ASN254
A	ASN370
A	ASN436
A	ASN445
A	ASN547
A	ASN592

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN421

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000255

Chain	Residue	Details
A	SER593
A	SER603

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000255

Chain	Residue	Details
A	THR594
A	THR599

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