4R3V

Structure of karilysin propeptide and catalytic MMP domain

Summary for 4R3V

Entry DOI	10.2210/pdb4r3v/pdb
Related	2XS3 2XS4 4IN9
Descriptor	Karilysin, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	metzincin metallopeptidase, matrix metalloproteinase with unique propeptide, bacterial matrix metalloproteinase-like enzyme, hydrolase
Biological source	Tannerella forsythia
Cellular location	Secreted : D0EM77
Total number of polymer chains	2
Total formula weight	41394.91
Authors	Lopez-Pelegrin, M.,Ksiazek, M.,Karim, A.Y.,Guevara, T.,Arolas, J.L.,Potempa, J.,Gomis-Ruth, F.X. (deposition date: 2014-08-18, release date: 2015-01-07, Last modification date: 2023-09-20)
Primary citation	Lopez-Pelegrin, M.,Ksiazek, M.,Karim, A.Y.,Guevara, T.,Arolas, J.L.,Potempa, J.,Gomis-Ruth, F.X. A novel mechanism of latency in matrix metalloproteinases. J.Biol.Chem., 290:4728-4740, 2015 Cited by PubMed: 25555916 DOI: 10.1074/jbc.M114.605956 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation