4R3V
Structure of karilysin propeptide and catalytic MMP domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | ASP25 |
| A | HIS155 |
| A | HIS159 |
| A | HIS165 |
| A | HOH452 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | HIS102 |
| A | ASP104 |
| A | HIS117 |
| A | HIS133 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 303 |
| Chain | Residue |
| A | ASP109 |
| A | GLY110 |
| A | THR112 |
| A | ILE114 |
| A | ASP135 |
| A | GLU138 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 304 |
| Chain | Residue |
| A | PRO28 |
| A | LEU29 |
| A | THR30 |
| A | ASN33 |
| A | TYR106 |
| B | ASN34 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 305 |
| Chain | Residue |
| A | LYS41 |
| A | TRP42 |
| A | ASN43 |
| A | LYS44 |
| A | LEU195 |
| A | TYR196 |
| A | GOL306 |
| B | ASN101 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 306 |
| Chain | Residue |
| A | ASP194 |
| A | GLY197 |
| A | GOL305 |
| B | ASN101 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | ASP25 |
| B | HIS155 |
| B | HIS159 |
| B | HIS165 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS102 |
| B | ASP104 |
| B | HIS117 |
| B | HIS133 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 303 |
| Chain | Residue |
| B | ASP109 |
| B | GLY110 |
| B | THR112 |
| B | ILE114 |
| B | ASP135 |
| B | GLU138 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 26 |
| Details | Propeptide: {"description":"Activation peptide","featureId":"PRO_0000425866"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21166898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23695557","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21166898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23695557","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
