7ANK

Crystal structure of sarcomeric protein FATZ-1 (d91-FATZ-1 construct) in complex with half dimer of alpha-actinin-2

Summary for 7ANK

• Entry DOI: 10.2210/pdb7ank/pdb
• Related: 7A8T 7A8U
• Descriptor: Alpha-actinin-2, Myozenin-1 (3 entities in total)
• Functional Keywords: z-disk complex, f-actin crosslinking protein, scaffolding protein, fuzzy complex, structural protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 128694.74

Authors

Sponga, A.,Arolas, J.L.,Rodriguez Chamorro, A.,Mlynek, G.,Hollerl, E.,Schreiner, C.,Pedron, M.,Kostan, J.,Ribeiro, E.A.,Djinovic-Carugo, K. (deposition date: 2020-10-12, release date: 2021-06-30, Last modification date: 2024-01-31)

• Primary citation: Sponga, A.,Arolas, J.L.,Schwarz, T.C.,Jeffries, C.M.,Rodriguez Chamorro, A.,Kostan, J.,Ghisleni, A.,Drepper, F.,Polyansky, A.,De Almeida Ribeiro, E.,Pedron, M.,Zawadzka-Kazimierczuk, A.,Mlynek, G.,Peterbauer, T.,Doto, P.,Schreiner, C.,Hollerl, E.,Mateos, B.,Geist, L.,Faulkner, G.,Kozminski, W.,Svergun, D.I.,Warscheid, B.,Zagrovic, B.,Gautel, M.,Konrat, R.,Djinovic-Carugo, K.; Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with alpha-actinin.; Sci Adv, 7:-, 2021; PubMed: 34049882; DOI: 10.1126/sciadv.abg7653

Experimental method

X-RAY DIFFRACTION (3.204 Å)