2FEC
| Structure of the E203Q mutant of the Cl-/H+ exchanger CLC-ec1 from E.Coli | Descriptor: | Fab fragment, heavy chain, light chain, ... | Authors: | Accardi, A, Walden, M.P, Nguitragool, W, Jayaram, H, Williams, C, Miller, C. | Deposit date: | 2005-12-15 | Release date: | 2006-01-03 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.967 Å) | Cite: | Separate ion pathways in a Cl-/H+ exchanger J.Gen.Physiol., 126, 2005
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2FEE
| Structure of the Cl-/H+ exchanger CLC-ec1 from E.Coli in NaBr | Descriptor: | Fab fragment, heavy chain, light chain, ... | Authors: | Accardi, A, Walden, M.P, Nguitragool, W, Jayaram, H, Williams, C, Miller, C. | Deposit date: | 2005-12-15 | Release date: | 2006-01-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Separate ion pathways in a Cl-/H+ exchanger J.Gen.Physiol., 126, 2005
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2HLF
| Structure of the Escherichis coli ClC chloride channel Y445E mutant and Fab complex | Descriptor: | BROMIDE ION, Fab Fragment, Heavy chain, ... | Authors: | Accardi, A, Lobet, S, Williams, C, Miller, C, Dutzler, R. | Deposit date: | 2006-07-07 | Release date: | 2006-09-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger J.Mol.Biol., 362, 2006
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2HT2
| Structure of the Escherichia coli ClC chloride channel Y445H mutant and Fab complex | Descriptor: | BROMIDE ION, Fab fragment, heavy chain, ... | Authors: | Accardi, A, Lobet, S, Williams, C, Miller, C, Dutzler, R. | Deposit date: | 2006-07-25 | Release date: | 2006-09-19 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger. J.Mol.Biol., 362, 2006
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2HT3
| Structure of the Escherichia coli ClC chloride channel Y445L mutant and Fab complex | Descriptor: | BROMIDE ION, Fab fragment, Heavy chain, ... | Authors: | Accardi, A, Lobet, S, Williams, C, Miller, C, Dutzler, R. | Deposit date: | 2006-07-25 | Release date: | 2006-09-19 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Synergism between halide binding and proton transport in a CLC-type exchanger J.Mol.Biol., 362, 2006
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2HT4
| Structure of the Escherichia coli ClC chloride channel Y445W mutant and Fab complex | Descriptor: | BROMIDE ION, Fab fragment, Heavy chain, ... | Authors: | Accardi, A, Lobet, S, Williams, C, Miller, C, Dutzler, R. | Deposit date: | 2006-07-25 | Release date: | 2006-09-19 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger. J.Mol.Biol., 362, 2006
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2HTL
| Structure of the Escherichia coli ClC chloride channel Y445F mutant and Fab complex | Descriptor: | BROMIDE ION, Fab fragment, Heavy chain, ... | Authors: | Accardi, A, Lobet, S, Williams, C, Miller, C, Dutzler, R. | Deposit date: | 2006-07-26 | Release date: | 2006-09-19 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger. J.Mol.Biol., 362, 2006
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2FED
| Structure of the E203Q mutant of the Cl-/H+ exchanger CLC-ec1 from E.Coli | Descriptor: | Fab fragment, heavy chain, light chain, ... | Authors: | Accardi, A, Walden, M.P, Nguitragool, W, Jayaram, H, Williams, C, Miller, C. | Deposit date: | 2005-12-15 | Release date: | 2006-01-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.317 Å) | Cite: | Separate ion pathways in a Cl-/H+ exchanger J.Gen.Physiol., 126, 2005
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2HTK
| Structure of the Escherichia coli ClC chloride channel Y445A mutant and Fab complex | Descriptor: | BROMIDE ION, Fab fragment, Heavy chain, ... | Authors: | Accardi, A, Lobet, S, Williams, C, Miller, C, Dutzler, R. | Deposit date: | 2006-07-26 | Release date: | 2006-09-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | Synergism between halide binding and proton transport in a CLC-type exchanger J.Mol.Biol., 362, 2006
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6OY3
| nhTMEM16 L302A +Ca2+ in nanodiscs | Descriptor: | CALCIUM ION, nhTMEM16 | Authors: | Falzone, M, Lee, B.C, Accardi, A. | Deposit date: | 2019-05-14 | Release date: | 2019-11-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca 2+ -bound nhTMEM16. Nat Commun, 10, 2019
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3DET
| Structure of the E148A, Y445A doubly ungated mutant of E.coli CLC_Ec1, Cl-/H+ antiporter | Descriptor: | Fab fragment, Heavy chain, Light chain, ... | Authors: | Jayaram, H, Accardi, A, Wu, F, Williams, C, Miller, C. | Deposit date: | 2008-06-10 | Release date: | 2008-06-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger Proc.Natl.Acad.Sci.USA, 105, 2008
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8GA0
| CLC-ec1 E202Y at pH 4.5 100mM Cl Turn | Descriptor: | H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GAH
| CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Twist | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GA3
| CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Turn | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GA1
| CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Swap | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GA5
| CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Intermediate | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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6E1O
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6DZ7
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6E0H
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7RX2
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7RXA
| afTMEM16 DE/AA mutant in C14 lipid nanodiscs in the presence of Ca2+ | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, afTMEM16 lipid scramblase | Authors: | Feng, Z, Accardi, A. | Deposit date: | 2021-08-22 | Release date: | 2022-05-18 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | TMEM16 scramblases thin the membrane to enable lipid scrambling. Nat Commun, 13, 2022
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7RXH
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7RXB
| afTMEM16 lipid scramblase in C18 lipid nanodiscs in the absence of Ca2+ | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, afTMEM16 lipid scramblase | Authors: | Feng, Z, Accardi, A. | Deposit date: | 2021-08-22 | Release date: | 2022-05-18 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | TMEM16 scramblases thin the membrane to enable lipid scrambling. Nat Commun, 13, 2022
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7RX3
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7RXG
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