3DET

Structure of the E148A, Y445A doubly ungated mutant of E.coli CLC_Ec1, Cl-/H+ antiporter

Summary for 3DET

• Entry DOI: 10.2210/pdb3det/pdb
• Related: 1OTS 1OTT 2HTK
• Descriptor: H(+)/Cl(-) exchange transporter clcA, Fab fragment, Heavy chain, Fab fragment, Light chain (3 entities in total)
• Functional Keywords: clc_ec1, antiporter, exchange-transporter, doubly ungated mutant, chloride, inner membrane, ion transport, membrane, stress response, transmembrane, membrane protein
• Biological source: Escherichia coli; More
• Cellular location: Cell inner membrane; Multi-pass membrane protein (Probable): P37019
• Total number of polymer chains: 6
• Total formula weight: 194045.27

Authors

Jayaram, H.,Accardi, A.,Wu, F.,Williams, C.,Miller, C. (deposition date: 2008-06-10, release date: 2008-06-17, Last modification date: 2023-08-30)

• Primary citation: Jayaram, H.,Accardi, A.,Wu, F.,Williams, C.,Miller, C.; Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger; Proc.Natl.Acad.Sci.USA, 105:11194-11199, 2008; PubMed: 18678918; DOI: 10.1073/pnas.0804503105

Experimental method

X-RAY DIFFRACTION (2.8 Å)