6E1O

afTMEM16 reconstituted in nanodiscs in the presence of Ca2+ and ceramide 24:0

Summary for 6E1O

• Entry DOI: 10.2210/pdb6e1o/pdb
• Related: 6DZ7 6E0H
• EMDB information: 8931 8948 8959
• Descriptor: Plasma membrane channel protein (Aqy1), putative, CALCIUM ION, DODECANE, ... (6 entities in total)
• Functional Keywords: scramblase, ca2+-activated, membrane-reorganization, lipid transport
• Biological source: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
• Total number of polymer chains: 2
• Total formula weight: 171722.61

Authors

Falzone, M.E.,Accardi, A. (deposition date: 2018-07-10, release date: 2019-02-06, Last modification date: 2024-03-13)

• Primary citation: Falzone, M.E.,Rheinberger, J.,Lee, B.C.,Peyear, T.,Sasset, L.,Raczkowski, A.M.,Eng, E.T.,Di Lorenzo, A.,Andersen, O.S.,Nimigean, C.M.,Accardi, A.; Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.; Elife, 8:-, 2019; PubMed: 30648972; DOI: 10.7554/eLife.43229

Experimental method

ELECTRON MICROSCOPY (3.59 Å)