6E1O
afTMEM16 reconstituted in nanodiscs in the presence of Ca2+ and ceramide 24:0
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0017121 | biological_process | plasma membrane phospholipid scrambling |
| A | 0017128 | molecular_function | phospholipid scramblase activity |
| A | 0032541 | cellular_component | cortical endoplasmic reticulum |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| B | 0005245 | molecular_function | voltage-gated calcium channel activity |
| B | 0005254 | molecular_function | chloride channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0017121 | biological_process | plasma membrane phospholipid scrambling |
| B | 0017128 | molecular_function | phospholipid scramblase activity |
| B | 0032541 | cellular_component | cortical endoplasmic reticulum |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0045332 | biological_process | phospholipid translocation |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 801 |
| Chain | Residue |
| B | GLU445 |
| B | ASP511 |
| B | GLU514 |
| B | ASP547 |
| B | LYS550 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CA B 802 |
| Chain | Residue |
| B | GLU445 |
| B | GLU514 |
| B | GLU543 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue D12 B 803 |
| Chain | Residue |
| A | ARG629 |
| B | TRP578 |
| A | TYR626 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue D12 B 804 |
| Chain | Residue |
| B | ILE210 |
| B | THR613 |
| B | SER617 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue D12 B 805 |
| Chain | Residue |
| B | PHE388 |
| B | ARG391 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue D12 B 806 |
| Chain | Residue |
| B | ARG189 |
| B | PHE190 |
| B | PHE193 |
| B | TYR226 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue D10 B 807 |
| Chain | Residue |
| B | PHE575 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue 8K6 B 808 |
| Chain | Residue |
| B | TYR589 |
| B | SER592 |
| B | PHE616 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 801 |
| Chain | Residue |
| A | GLU445 |
| A | ASP511 |
| A | GLU514 |
| A | ASP547 |
| A | LYS550 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 802 |
| Chain | Residue |
| A | GLU445 |
| A | GLU514 |
| A | GLU543 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue D12 A 803 |
| Chain | Residue |
| A | TRP578 |
| B | TYR626 |
| B | ARG629 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue D12 A 804 |
| Chain | Residue |
| A | ILE210 |
| A | THR613 |
| A | SER617 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue D12 A 805 |
| Chain | Residue |
| A | ARG189 |
| A | PHE190 |
| A | PHE193 |
| A | TYR226 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue D12 A 806 |
| Chain | Residue |
| A | PHE388 |
| A | ARG391 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue D10 A 807 |
| Chain | Residue |
| A | PHE575 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue 8K6 A 808 |
| Chain | Residue |
| A | TYR589 |
| A | SER592 |
