Author results

1S7Z
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STRUCTURE OF OCR FROM BACTERIOPHAGE T7
Descriptor:Gene 0.3 protein, CESIUM ION
Authors:Walkinshaw, M.D., Taylor, P., Sturrock, S.S., Atanasiu, C., Berg, T., Henderson, R.M., Edwardson, J.M., Dryden, D.T.
Deposit date:2004-01-30
Release date:2004-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure of Ocr from Bacteriophage T7, a Protein that Mimics B-Form DNA
Mol.Cell, 9, 2002
1CTX
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THREE-DIMENSIONAL STRUCTURE OF THE-LONG-NEUROTOXIN FROM COBRA VENOM
Descriptor:ALPHA-COBRATOXIN
Authors:Saenger, W., Walkinshaw, M.D.
Deposit date:1982-04-08
Release date:1982-05-26
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Three-dimensional structure of the "long" neurotoxin from cobra venom.
Proc.Natl.Acad.Sci.USA, 77, 1980
3FWT
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR MIF2
Descriptor:Macrophage migration inhibitory factor-like protein
Authors:Walkinshaw, M.D., Richardson, J.M.
Deposit date:2009-01-19
Release date:2009-03-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of Leishmania major orthologues of macrophage migration inhibitory factor
Biochem.Biophys.Res.Commun., 380, 2009
3IS4
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE (LMPYK)IN COMPLEX WITH 1,3,6,8-PYRENETETRASULFONIC ACID
Descriptor:Pyruvate kinase, GLYCEROL, pyrene-1,3,6,8-tetrasulfonic acid
Authors:Walkinshaw, M.D., Morgan, H.P.
Deposit date:2009-08-25
Release date:2010-03-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase
Acta Crystallogr.,Sect.F, 66, 2010
4FXF
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STRUCTURE OF M2 PYRUVATE KINASE IN COMPLEX WITH PHENYLALANINE
Descriptor:Pyruvate kinase isozymes M1/M2, OXALATE ION, POTASSIUM ION, ...
Authors:Walkinshaw, M.D., Morgan, H.P.
Deposit date:2012-07-03
Release date:2013-03-27
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4FXJ
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STRUCTURE OF M2 PYRUVATE KINASE IN COMPLEX WITH PHENYLALANINE
Descriptor:Pyruvate kinase isozymes M1/M2, PHOSPHATE ION, PHENYLALANINE
Authors:Walkinshaw, M.D., Morgan, H.P.
Deposit date:2012-07-03
Release date:2013-03-27
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.
Proc.Natl.Acad.Sci.USA, 110, 2013
1CWA
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X-RAY STRUCTURE OF A MONOMERIC CYCLOPHILIN A-CYCLOSPORIN A CRYSTAL COMPLEX AT 2.1 ANGSTROMS RESOLUTION
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Walkinshaw, M.D.
Deposit date:1995-09-06
Release date:1996-01-29
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-Ray Structure of a Monomeric Cyclophilin A-Cyclosporin a Crystal Complex at 2.1 A Resolution.
J.Mol.Biol., 234, 1993
1CWB
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THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Walkinshaw, M.D.
Deposit date:1995-09-06
Release date:1996-01-29
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The X-Ray Structure of (Mebm2T)1-Cyclosporin Complexed with Cyclophilin a Provides an Explanation for its Anomalously High Immunosuppressive Activity.
Protein Eng., 7, 1994
1CYN
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CYCLOPHILIN B COMPLEXED WITH [D-(CHOLINYLESTER)SER8]-CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Walkinshaw, M.D.
Deposit date:1995-05-22
Release date:1996-01-29
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-Ray Structure of a Cyclophilin B/Cyclosporin Complex: Comparison with Cyclophilin a and Delineation of its Calcineurin-Binding Domain.
Proc.Natl.Acad.Sci.USA, 91, 1994
1DYW
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BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF A DIVERGENT LOOP CYCLOPHILIN FROM CAENORHABDITIS ELEGANS
Descriptor:CYCLOPHILIN 3
Authors:Dornan, J., Page, A.P., Taylor, P., Wu, S.Y., Winter, A.D., Husi, H., Walkinshaw, M.D.
Deposit date:2000-02-10
Release date:2000-06-22
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biochemical and Structural Characterization of a Divergent Loop Cyclophilin from Caenorhabditis Elegans
J.Biol.Chem., 274, 1999
1PXM
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 3-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YLAMINO]-PHENOL
Descriptor:Cell division protein kinase 2, 3-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YLAMINO]-PHENOL
Authors:Wang, S., Meades, C., Wood, G., Osnowski, A., Anderson, S., Yuill, R., Thomas, M., Jackson, W., Midgley, C., Griffiths, G., McNae, I., Wu, S.Y., McInnes, C., Zheleva, D., Walkinshaw, M.D., Fischer, P.M.
Deposit date:2003-07-04
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.
J.Med.Chem., 47, 2004
1PXN
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-[4-(4-METHYL-2-METHYLAMINO-THIAZOL-5-YL)-PYRIMIDIN-2-YLAMINO]-PHENOL
Descriptor:Cell division protein kinase 2, 4-[4-(4-METHYL-2-METHYLAMINO-THIAZOL-5-YL)-PYRIMIDIN-2-YLAMINO]-PHENOL
Authors:Wang, S., Meades, C., Wood, G., Osnowski, A., Anderson, S., Yuill, R., Thomas, M., Mezna, M., Jackson, W., Midgley, C., Griffiths, G., McNae, I., Wu, S.Y., McInnes, C., Zheleva, D., Walkinshaw, M.D., Fischer, P.M.
Deposit date:2003-07-04
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.
J.Med.Chem., 47, 2004
1PXO
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR [4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE
Descriptor:Cell division protein kinase 2, [4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE
Authors:Wang, S., Meades, C., Wood, G., Osnowski, A., Anderson, S., Yuill, R., Thomas, M., Mezna, M., Jackson, W., Midgley, C., Griffiths, G., McNae, I., Wu, S.Y., McInnes, C., Zheleva, D., Walkinshaw, M.D., Fischer, P.M.
Deposit date:2003-07-04
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.
J.Med.Chem., 47, 2004
1PXP
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE
Descriptor:Cell division protein kinase 2, N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE
Authors:Wang, S., Meades, C., Wood, G., Osnowski, A., Anderson, S., Yuill, R., Thomas, M., Mezna, M., Jackson, W., Midgley, C., Griffiths, G., McNae, I., Wu, S.Y., McInnes, C., Zheleva, D., Walkinshaw, M.D., Fischer, P.M.
Deposit date:2003-07-04
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.
J.Med.Chem., 47, 2004
1E8K
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CYCLOPHILIN 3 COMPLEXED WITH DIPEPTIDE ALA-PRO
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 3, ALANINE, PROLINE
Authors:Wu, S.Y., Dornan, J., Kontopidis, G., Taylor, P., Walkinshaw, M.D.
Deposit date:2000-09-25
Release date:2001-09-20
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The First Direct Determination of a Ligand Binding Constant in Protein Crystals
Angew.Chem.Int.Ed.Engl., 40, 2001
1A58
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CYCLOPHILIN FROM BRUGIA MALAYI
Descriptor:CYCLOPHILIN
Authors:Taylor, P., Page, A.P., Kontopidis, G., Husi, H., Walkinshaw, M.D.
Deposit date:1998-02-20
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi.
FEBS Lett., 425, 1998
1BCK
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HUMAN CYCLOPHILIN A COMPLEXED WITH 2-THR CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN C
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-04-30
Release date:1998-09-16
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWF
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HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN D
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-04-30
Release date:1998-07-15
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWH
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HUMAN CYCLOPHILIN A COMPLEXED WITH 3-D-SER CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-07
Release date:1998-07-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWI
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HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN D
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-25
Release date:1998-08-12
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWJ
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HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-S-METHYL-SARCOSINE CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN D
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-25
Release date:1998-08-26
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWK
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HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN D
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-26
Release date:1998-07-15
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWL
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HUMAN CYCLOPHILIN A COMPLEXED WITH 4 4-HYDROXY-MELEU CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-26
Release date:1998-07-15
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWM
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HUMAN CYCLOPHILIN A COMPLEXED WITH 4 MEILE CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN A
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-05-26
Release date:1998-07-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.
J.Mol.Biol., 283, 1998
1CWO
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HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, CYCLOSPORIN C
Authors:Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.
Deposit date:1998-06-05
Release date:1998-08-12
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Conformational Differences of an Immunosuppressant Peptolide in a Single Crystal and in a Crystal Complex with Human Cyclophilin A.
J.Mol.Biol., 283, 1998