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5CCA
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BU of 5cca by Molmil
Crystal structure of Mtb toxin
Descriptor: Endoribonuclease MazF3
Authors:Cascio, D, Arbing, M, de Serrano, V, Eisenberg, D, Miallau, L, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-07-01
Release date:2016-09-07
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of Mtb toxin
To Be Published
4Q0G
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BU of 4q0g by Molmil
Crystal structure of beta subunit of acyl-CoA carboxylase AccD1 from Mycobacterium tuberculosis
Descriptor: GLYCEROL, Probable acetyl-/propionyl-CoA carboxylase (Beta subunit) AccD1
Authors:Bie, H.Y, Yin, J, James, M.N.G, TB Structural Genomics Consortium (TBSGC)
Deposit date:2014-04-02
Release date:2016-04-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystal structure of Beta subunit of acyl-CoA carboxylase AccD1 from Mycobacterium tuberculosis
To be Published
4WCW
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BU of 4wcw by Molmil
Ribosomal silencing factor during starvation or stationary phase (RsfS) from Mycobacterium tuberculosis
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, Ribosomal silencing factor RsfS
Authors:Li, X, Sun, Q, Jiang, C, Yang, K, Hung, L, Zhang, J, Sacchettini, J, TB Structural Genomics Consortium (TBSGC)
Deposit date:2014-09-05
Release date:2014-09-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome.
Structure, 23, 2015
1LQT
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BU of 1lqt by Molmil
A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase
Descriptor: 4-OXO-NICOTINAMIDE-ADENINE DINUCLEOTIDE PHOSPHATE, ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Bossi, R.T, Aliverti, A, Raimondi, D, Fischer, F, Zanetti, G, Ferrari, D, Tahallah, N, Maier, C.S, Heck, A.J.R, Rizzi, M, Mattevi, A, TB Structural Genomics Consortium (TBSGC)
Deposit date:2002-05-13
Release date:2002-07-31
Last modified:2024-12-25
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase.
Biochemistry, 41, 2002
1KP9
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BU of 1kp9 by Molmil
Crystal structure of mycolic acid cyclopropane synthase CmaA1, apo-form
Descriptor: ACETIC ACID, CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1
Authors:Huang, C.-C, Smith, C.V, Jacobs Jr, W.R, Glickman, M.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2001-12-30
Release date:2002-01-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis
J.Biol.Chem., 277, 2002
4UAQ
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BU of 4uaq by Molmil
Crystal structure of the accessory translocation ATPase, SecA2, from Mycobacterium tuberculosis
Descriptor: Protein translocase subunit SecA 2
Authors:Swanson-Smith, S, Ioerger, T.R, Rigel, N.W, Miller, B.K, Braunstein, M, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2014-08-11
Release date:2015-09-09
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.
J.Bacteriol., 198, 2015
5CYU
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BU of 5cyu by Molmil
Structure of the soluble domain of EccB1 from the Mycobacterium smegmatis ESX-1 secretion system.
Descriptor: Conserved membrane protein
Authors:Arbing, M.A, Chan, S, Kahng, S, Kim, J, Eisenberg, D.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-07-30
Release date:2015-08-12
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Bmc Struct.Biol., 16, 2016
5CXI
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BU of 5cxi by Molmil
Crystal structure of Mycobacterium tuberculosis KstR in complex with 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA (4-BNC-CoA)
Descriptor: 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA, HTH-type transcriptional repressor KstR
Authors:Ho, N.A.T, Dawes, S, Kendall, S, Casabon, I, Crowe, A.M, Baker, E.N, Eltis, L.D, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-07-29
Release date:2016-02-17
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
J.Biol.Chem., 291, 2016
3K7Z
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BU of 3k7z by Molmil
GCN4-Leucine zipper core mutant as N16A trigonal automatic solution
Descriptor: General control protein GCN4
Authors:Holton, J, Alber, T, TB Structural Genomics Consortium (TBSGC)
Deposit date:2009-10-13
Release date:2009-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Automated Protein Crystal Structure Determination Using Elves.
Proc.Natl.Acad.Sci.USA, 101, 2004
1UE1
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BU of 1ue1 by Molmil
Crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosis
Descriptor: Single-strand binding protein, ZINC ION
Authors:Saikrishnan, K, Jeyakanthan, J, Venkatesh, J, Acharya, N, Sekar, K, Varshney, U, Vijayan, M, TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-05-08
Release date:2004-02-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Mycobacterium tuberculosis single-stranded DNA-binding protein. Variability in quaternary structure and its implications
J.MOL.BIOL., 331, 2003
1UE7
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BU of 1ue7 by Molmil
Crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosis
Descriptor: Single-strand binding protein
Authors:Saikrishnan, K, Jeyakanthan, J, Venkatesh, J, Acharya, N, Sekar, K, Varshney, U, Vijayan, M, TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-05-09
Release date:2004-02-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Mycobacterium tuberculosis single-stranded DNA-binding protein. Variability in quaternary structure and its implications
J.MOL.BIOL., 331, 2003
1UE5
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BU of 1ue5 by Molmil
Crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosis
Descriptor: CADMIUM ION, Single-strand binding protein
Authors:Saikrishnan, K, Jeyakanthan, J, Venkatesh, J, Acharya, N, Sekar, K, Varshney, U, Vijayan, M, TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-05-09
Release date:2004-02-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Mycobacterium tuberculosis single-stranded DNA-binding protein. Variability in quaternary structure and its implications
J.MOL.BIOL., 331, 2003
1UE6
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BU of 1ue6 by Molmil
Crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosis
Descriptor: Single-strand binding protein
Authors:Saikrishnan, K, Jeyakanthan, J, Venkatesh, J, Acharya, N, Sekar, K, Varshney, U, Vijayan, M, TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-05-09
Release date:2004-02-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of Mycobacterium tuberculosis single-stranded DNA-binding protein. Variability in quaternary structure and its implications
J.MOL.BIOL., 331, 2003
1U0R
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BU of 1u0r by Molmil
Crystal structure of Mycobacterium tuberculosis NAD kinase
Descriptor: Inorganic polyphosphate/ATP-NAD kinase
Authors:Garavaglia, S, Raffaelli, N, Finaurini, L, Magni, G, Rizzi, M, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-07-14
Release date:2004-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis
J.Biol.Chem., 279, 2004
1U5H
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BU of 1u5h by Molmil
Structure of Citrate Lyase beta subunit from Mycobacterium tuberculosis
Descriptor: FORMIC ACID, citE
Authors:Goulding, C.W, Lekin, T, Kim, C.Y, Segelke, B, Terwilliger, T.C, Eisenberg, D, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-07-27
Release date:2004-10-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The structure and computational analysis of Mycobacterium tuberculosis protein CitE suggest a novel enzymatic function.
J.Mol.Biol., 365, 2007
1U5V
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BU of 1u5v by Molmil
Structure of CitE complexed with triphosphate group of ATP form Mycobacterium tuberculosis
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, FORMIC ACID, citE
Authors:Goulding, C.W, Lerkin, T, Kim, C.Y, Segelke, B, Terwilliger, T, Eisenberg, E, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-07-28
Release date:2004-10-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of Mycobacterium tuberculosis citrate lyase beta subunit and its unusual triphosphate binding site
To be Published
1TXO
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BU of 1txo by Molmil
Crystal structure of the Mycobacterium tuberculosis serine/threonine phosphatase PstP/Ppp at 1.95 A.
Descriptor: MANGANESE (II) ION, Putative Bacterial Enzyme
Authors:Pullen, K.E, Ng, H.L, Sung, P.Y, Good, M.C, Smith, S.M, Alber, T, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-07-05
Release date:2004-11-23
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An Alternate Conformation and a Third Metal in PstP/Ppp, the M. tuberculosis PP2C-Family Ser/Thr Protein Phosphatase.
Structure, 12, 2004
2I6U
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BU of 2i6u by Molmil
Crystal Structure of Ornithine Carbamoyltransferase complexed with Carbamoyl Phosphate and L-Norvaline from Mycobacterium tuberculosis (Rv1656) at 2.2 A
Descriptor: NORVALINE, Ornithine carbamoyltransferase, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER, ...
Authors:Sankaranarayanan, R, Moradian, F, Cherney, L.T, Garen, C, Cherney, M.M, James, M.N.G, TB Structural Genomics Consortium (TBSGC)
Deposit date:2006-08-29
Release date:2007-06-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism
J.Mol.Biol., 375, 2008
2I3G
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BU of 2i3g by Molmil
Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis in complex with NADP+.
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-acetyl-gamma-glutamyl-phosphate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Cherney, L.T, Cherney, M.M, Garen, C.R, Moraidin, F, James, M.N.G, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB), TB Structural Genomics Consortium (TBSGC)
Deposit date:2006-08-18
Release date:2006-09-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of N-acetyl-gamma-glutamyl-phosphate Reductase from Mycobacterium tuberculosis in Complex with NADP(+).
J.Mol.Biol., 367, 2007
1C3V
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BU of 1c3v by Molmil
DIHYDRODIPICOLINATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND PDC
Descriptor: DIHYDRODIPICOLINATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PYRIDINE-2,6-DICARBOXYLIC ACID, ...
Authors:Cirilli, M, Zheng, R, Scapin, G, Blanchard, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:1999-07-28
Release date:2003-08-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity
Biochemistry, 42, 2003
1BVR
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BU of 1bvr by Molmil
M.TB. ENOYL-ACP REDUCTASE (INHA) IN COMPLEX WITH NAD+ AND C16-FATTY-ACYL-SUBSTRATE
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE), TRANS-2-HEXADECENOYL-(N-ACETYL-CYSTEAMINE)-THIOESTER
Authors:Rozwarski, D.A, Vilcheze, C, Sugantino, M, Bittman, R, Jacobs, W, TB Structural Genomics Consortium (TBSGC)
Deposit date:1998-09-17
Release date:1999-09-17
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate.
J.Biol.Chem., 274, 1999
8GKF
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BU of 8gkf by Molmil
Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.
Descriptor: 4'-phosphopantetheinyl transferase PptT, TOMUDEX
Authors:Krieger, I.V, Singh, A, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2023-03-18
Release date:2024-03-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.
Sci Adv, 10, 2024
9C2R
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BU of 9c2r by Molmil
M. tuberculosis PKS13 acyltransferase (AT) domain sulfate free apo form
Descriptor: PENTAETHYLENE GLYCOL, Polyketide synthase Pks13, SULFATE ION, ...
Authors:Krieger, I.K, Tang, S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2024-05-31
Release date:2025-05-07
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:A SuFEx-based TB clinical candidate irreversibly inhibits Pks13
To Be Published
9C0P
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BU of 9c0p by Molmil
M. tuberculosis PKS13 acyltransferase (AT) domain in complex with SuFEx inhibitor CEC215
Descriptor: N-{4-[(4-{[fluorodi(hydroxy)-lambda~4~-sulfanyl]oxy}phenoxy)methyl]phenyl}acetamide, PENTAETHYLENE GLYCOL, Polyketide synthase Pks13, ...
Authors:Krieger, I.K, Tang, S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2024-05-27
Release date:2025-05-07
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:A SuFEx-based TB clinical candidate irreversibly inhibits Pks13
To Be Published
9C9O
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BU of 9c9o by Molmil
M. tuberculosis PKS13 acyltransferase (AT) domain in complex with SuFEx inhibitor CMX410 - reaction product
Descriptor: 4-({2,6-difluoro-4-[3-(methanesulfonamido)-1H-1,2,4-triazol-1-yl]phenyl}methoxy)phenyl hydrogen sulfate, PENTAETHYLENE GLYCOL, Polyketide synthase Pks13, ...
Authors:Krieger, I.V, Tang, S, Sacchetini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2024-06-14
Release date:2025-05-07
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:A SuFEx-based TB clinical candidate irreversibly inhibits Pks13
To Be Published

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