Author results

4Q0G
  • Download 4q0g
  • View 4q0g
Molmil generated image of 4q0g
CRYSTAL STRUCTURE OF BETA SUBUNIT OF ACYL-COA CARBOXYLASE ACCD1 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Probable acetyl-/propionyl-CoA carboxylase (Beta subunit) AccD1, GLYCEROL
Authors:Bie, H.Y., Yin, J., James, M.N.G., TB Structural Genomics Consortium (TBSGC)
Deposit date:2014-04-02
Release date:2016-04-20
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystal structure of Beta subunit of acyl-CoA carboxylase AccD1 from Mycobacterium tuberculosis
To be Published
5CCA
  • Download 5cca
  • View 5cca
Molmil generated image of 5cca
CRYSTAL STRUCTURE OF MTB TOXIN
Descriptor:Endoribonuclease MazF3
Authors:Cascio, D., Arbing, M., de Serrano, V., Eisenberg, D., Miallau, L., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-07-01
Release date:2016-09-07
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of Mtb toxin
To Be Published
1QPQ
  • Download 1qpq
  • View 1qpq
Molmil generated image of 1qpq
STRUCTURE OF QUINOLINIC ACID PHOSPHORIBOSYLTRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS: A POTENTIAL TB DRUG TARGET
Descriptor:QUINOLINATE PHOSPHORIBOSYLTRANSFERASE, SULFATE ION, QUINOLINIC ACID
Authors:Sharma, V., Grubmeyer, C., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:1998-11-20
Release date:1998-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target.
Structure, 6, 1998
4GZR
  • Download 4gzr
  • View 4gzr
Molmil generated image of 4gzr
CRYSTAL STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS H37RV ESXOP (RV2346C-RV2347C) COMPLEX IN SPACE GROUP C2221
Descriptor:ESAT-6-like protein 6, ESAT-6-like protein 7, SULFATE ION
Authors:Arbing, M.A., Chan, S., He, Q., Harris, L., Zhou, T.T., Kuo, E., Ahn, C.J., Eisenberg, D., TB Structural Genomics Consortium (TBSGC), Integrated Center for Structure and Function Innovation (ISFI)
Deposit date:2012-09-06
Release date:2012-09-26
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (2.553 Å)
Cite:Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions.
Plos One, 8, 2013
1QPN
  • Download 1qpn
  • View 1qpn
Molmil generated image of 1qpn
QUINOLINATE PHOSPHORIBOSYL TRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH NCNN
Descriptor:PROTEIN (QUINOLINATE PHOSPHORIBOSYL TRANSFERASE), NICOTINATE MONONUCLEOTIDE
Authors:Sharma, V., Grubmeyer, C., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:1998-11-20
Release date:1998-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target.
Structure, 6, 1998
1QPO
  • Download 1qpo
  • View 1qpo
Molmil generated image of 1qpo
QUINOLINATE PHOSPHORIBOSYL TRANSFERASE (QAPRTASE) APO-ENZYME FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:QUINOLINATE ACID PHOSPHORIBOSYL TRANSFERASE, SULFATE ION
Authors:Sharma, V., Grubmeyer, C., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:1998-11-21
Release date:1998-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target.
Structure, 6, 1998
1QPR
  • Download 1qpr
  • View 1qpr
Molmil generated image of 1qpr
QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (QAPRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PHTHALATE AND PRPCP
Descriptor:QUINOLINIC ACID PHOSPHORIBOSYLTRANSFERASE, MANGANESE (II) ION, PHTHALIC ACID, ...
Authors:Sharma, V., Grubmeyer, C., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:1998-10-17
Release date:1998-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target.
Structure, 6, 1998
3B4T
  • Download 3b4t
  • View 3b4t
Molmil generated image of 3b4t
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS RNASE PH, THE MYCOBACTERIUM TUBERCULOSIS STRUCTURAL GENOMICS CONSORTIUM TARGET RV1340
Descriptor:Ribonuclease PH, PHOSPHATE ION
Authors:Antczak, A.J., Berger, J.M., Lekin, T., Segelke, B.W., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB), TB Structural Genomics Consortium (TBSGC)
Deposit date:2007-10-24
Release date:2007-11-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:2.1 A Crystal structure of RNase PH from Mycobacterium tuberculosis.
To be Published
1BVR
  • Download 1bvr
  • View 1bvr
Molmil generated image of 1bvr
M.TB. ENOYL-ACP REDUCTASE (INHA) IN COMPLEX WITH NAD+ AND C16-FATTY-ACYL-SUBSTRATE
Descriptor:PROTEIN (ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRANS-2-HEXADECENOYL-(N-ACETYL-CYSTEAMINE)-THIOESTER
Authors:Rozwarski, D.A., Vilcheze, C., Sugantino, M., Bittman, R., Jacobs, W., TB Structural Genomics Consortium (TBSGC)
Deposit date:1998-09-17
Release date:1999-09-17
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate.
J.Biol.Chem., 274, 1999
1NYO
  • Download 1nyo
  • View 1nyo
Molmil generated image of 1nyo
SOLUTION STRUCTURE OF THE ANTIGENIC TB PROTEIN MPT70/MPB70
Descriptor:Immunogenic protein MPT70
Authors:Bloemink, M.J., Dentten, E., Hewinson, R.G., Williamson, R.A., Carr, M.D., TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-02-13
Release date:2003-08-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease
J.Biol.Chem., 278, 2003
4ISB
  • Download 4isb
  • View 4isb
Molmil generated image of 4isb
CRYSTAL STRUCTURE OF APO MTB FADD10
Descriptor:Long chain fatty acid CoA ligase FadD10, SULFATE ION
Authors:Liu, Z., Wang, F., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:2013-01-16
Release date:2013-05-08
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme.
J.Biol.Chem., 288, 2013
1RFE
  • Download 1rfe
  • View 1rfe
Molmil generated image of 1rfe
CRYSTAL STRUCTURE OF CONSERVED HYPOTHETICAL PROTEIN RV2991 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:hypothetical protein Rv2991
Authors:Benini, S., Haouz, A., Proux, F., Betton, J.M., Alzari, P., Dodson, G.G., Wilson, K.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-11-08
Release date:2004-12-28
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F420binding protein with unknown function.
J. Struct. Biol., 2019
2FGG
  • Download 2fgg
  • View 2fgg
Molmil generated image of 2fgg
CRYSTAL STRUCTURE OF RV2632C
Descriptor:Hypothetical protein Rv2632c/MT2708
Authors:Yu, M., Bursey, E.H., Radhakannan, T., Segelke, B.W., Lekin, T., Toppani, D., Kim, C.Y., Kaviratne, T., Woodruff, T., Terwilliger, T.C., Hung, L.W., TB Structural Genomics Consortium (TBSGC)
Deposit date:2005-12-21
Release date:2006-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Rv2632c
To be Published
3ERE
  • Download 3ere
  • View 3ere
Molmil generated image of 3ere
CRYSTAL STRUCTURE OF THE ARGININE REPRESSOR PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE DNA OPERATOR
Descriptor:Arginine repressor, 5'-D(*DTP*DTP*DGP*DCP*DAP*DTP*DAP*DAP*DCP*DGP*DAP*DTP*DGP*DCP*DAP*DA)-3', 5'-D(*DTP*DTP*DGP*DCP*DAP*DTP*DCP*DGP*DTP*DTP*DAP*DTP*DGP*DCP*DAP*DA)-3', ...
Authors:Cherney, L.T., Cherney, M.M., Garen, C.R., Lu, G.J., James, M.N., TB Structural Genomics Consortium (TBSGC)
Deposit date:2008-10-01
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the arginine repressor protein in complex with the DNA operator from Mycobacterium tuberculosis.
J.Mol.Biol., 384, 2008
3FHZ
  • Download 3fhz
  • View 3fhz
Molmil generated image of 3fhz
CRYSTAL STRUCTURE OF THE ARGININE REPRESSOR FROM MYCOBACTERIUM TUBERCULOSIS BOUND WITH ITS DNA OPERATOR AND CO-REPRESSOR, L-ARGININE
Descriptor:Arginine repressor, 5'-D(*TP*GP*TP*TP*GP*CP*AP*TP*AP*AP*CP*GP*AP*TP*GP*CP*AP*AP*AP*A)-3', 5'-D(*TP*TP*TP*TP*GP*CP*AP*TP*CP*GP*TP*TP*AP*TP*GP*CP*AP*AP*CP*A)-3', ...
Authors:Cherney, L.T., Cherney, M.M., Garen, C.R., James, M.N.G., TB Structural Genomics Consortium (TBSGC)
Deposit date:2008-12-10
Release date:2009-03-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:The structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and Co-repressor, L-arginine.
J.Mol.Biol., 388, 2009
1MO4
  • Download 1mo4
  • View 1mo4
Molmil generated image of 1mo4
RECA-ATP-GAMMA-S COMPLEX
Descriptor:RecA, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Datta, S., Ganesh, N., Chandra, N.R., TB Structural Genomics Consortium (TBSGC)
Deposit date:2002-09-07
Release date:2003-02-18
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural studies on MtRecA-nucleotide complexes: Insights into DNA and nucleotide binding and the structural signature of NTP recognition
Proteins, 50, 2003
1MO5
  • Download 1mo5
  • View 1mo5
Molmil generated image of 1mo5
RECA-ATP-GAMMA-S-MG COMPLEX
Descriptor:RecA, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Datta, S., Ganesh, N., Chandra, N.R., TB Structural Genomics Consortium (TBSGC)
Deposit date:2002-09-07
Release date:2003-02-18
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural studies on MtRecA-nucleotide complexes: Insights into DNA and nucleotide binding and the structural signature of NTP recognition
Proteins, 50, 2003
1W0D
  • Download 1w0d
  • View 1w0d
Molmil generated image of 1w0d
THE HIGH RESOLUTION STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LEUB (RV2995C)
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE, SULFATE ION
Authors:Singh, R.K., Kefala, G., Janowski, R., Mueller-Dieckmann, C., Weiss, M.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-06-03
Release date:2004-12-14
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The High Resolution Structure of Leub (Rv2995C) from Mycobacterium Tuberculosis
J.Mol.Biol., 346, 2005
3DHY
  • Download 3dhy
  • View 3dhy
Molmil generated image of 3dhy
CRYSTAL STRUCTURES OF MYCOBACTERIUM TUBERCULOSIS S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE IN TERNARY COMPLEX WITH SUBSTRATE AND INHIBITORS
Descriptor:Adenosylhomocysteinase, 5'-S-ethyl-5'-thioadenosine, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Shetty, N.D., Ioerger, T.R., Gokulan, K., Reddy, M.C.M., Owen, J.L., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:2008-06-19
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
3MML
  • Download 3mml
  • View 3mml
Molmil generated image of 3mml
ALLOPHANATE HYDROLASE COMPLEX FROM MYCOBACTERIUM SMEGMATIS, MSMEG0435-MSMEG0436
Descriptor:Allophanate hydrolase subunit 2, Allophanate hydrolase subunit 1, CHLORIDE ION
Authors:Kaufmann, M., Chernishof, I., Shin, A., Germano, D., Sawaya, M.R., Waldo, G.S., Arbing, M.A., Perry, J., Eisenberg, D., Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-04-20
Release date:2010-04-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Allphanate Hydrolase Complex from M. smegmatis, Msmeg0435-Msmeg0436
To be Published
3QQS
  • Download 3qqs
  • View 3qqs
Molmil generated image of 3qqs
ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS172)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-16
Release date:2012-08-22
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QS8
  • Download 3qs8
  • View 3qs8
Molmil generated image of 3qs8
ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS174)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-20
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QSA
  • Download 3qsa
  • View 3qsa
Molmil generated image of 3qsa
ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR TAMU-A7)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-20
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Inhibition of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase by blocking of an active site entrance tunnel.
To be Published
3R6C
  • Download 3r6c
  • View 3r6c
Molmil generated image of 3r6c
ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS179)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-03-21
Release date:2012-09-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3UNO
  • Download 3uno
  • View 3uno
Molmil generated image of 3uno
MYCOBACTERIUM TUBERCULOSIS FERRITIN HOMOLOG, BFRB
Descriptor:Probable bacterioferritin BfrB
Authors:McMath, L.M., Contreras, H., Goulding, C.W., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-11-16
Release date:2012-11-21
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Mycobacterium tuberculosis ferritin homolog, BfrB
To be Published