5CXI
Crystal structure of Mycobacterium tuberculosis KstR in complex with 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA (4-BNC-CoA)
Summary for 5CXI
Entry DOI | 10.2210/pdb5cxi/pdb |
Related | 3MNL 5CW8 |
Descriptor | HTH-type transcriptional repressor KstR, 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA (3 entities in total) |
Functional Keywords | transcriptional repressor, tetr family tcholesterol catabolism, coa thioester ligand, structural genomics, tb structural genomics consortium, tbsgc, transcription |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 46893.03 |
Authors | Ho, N.A.T.,Dawes, S.,Kendall, S.,Casabon, I.,Crowe, A.M.,Baker, E.N.,Eltis, L.D.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-07-29, release date: 2016-02-17, Last modification date: 2024-03-06) |
Primary citation | Ho, N.A.,Dawes, S.S.,Crowe, A.M.,Casabon, I.,Gao, C.,Kendall, S.L.,Baker, E.N.,Eltis, L.D.,Lott, J.S. The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis. J.Biol.Chem., 291:7256-7266, 2016 Cited by PubMed: 26858250DOI: 10.1074/jbc.M115.707760 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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