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5JN8
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CRYSTAL STRUCTURE FOR THE COMPLEX OF HUMAN CARBONIC ANHYDRASE IV AND ACETAZOLAMIDE
Descriptor:Carbonic anhydrase 4, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ZINC ION, ...
Authors:Chen, Z., Waheed, A., Di Cera, E., Sly, W.S.
Deposit date:2016-04-29
Release date:2017-05-03
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
5JN9
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CRYSTAL STRUCTURE FOR THE COMPLEX OF HUMAN CARBONIC ANHYDRASE IV AND ETHOXYZOLAMIDE
Descriptor:Carbonic anhydrase 4, ZINC ION, 6-ethoxy-1,3-benzothiazole-2-sulfonamide, ...
Authors:Chen, Z., Waheed, A., Di Cera, E., Sly, W.S.
Deposit date:2016-04-29
Release date:2017-05-03
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
5JNA
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CRYSTAL STRUCTURE FOR THE COMPLEX OF HUMAN CARBONIC ANHYDRASE IV AND TOPIRAMATE
Descriptor:Carbonic anhydrase 4, ZINC ION, [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate, ...
Authors:Chen, Z., Waheed, A., Di Cera, E., Sly, W.S.
Deposit date:2016-04-29
Release date:2017-05-03
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
5JNC
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CRYSTAL STRUCTURE FOR THE COMPLEX OF HUMAN CARBONIC ANHYDRASE IV AND 4-AMINOMETHYLBENZENE SULFONAMIDE
Descriptor:Carbonic anhydrase 4, ZINC ION, 4-(aminomethyl)benzene-1-sulfonamide, ...
Authors:Chen, Z., Waheed, A., Di Cera, E., Sly, W.S.
Deposit date:2016-04-29
Release date:2017-05-03
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
5KU6
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CRYSTAL STRUCTURE FOR THE COMPLEX OF HUMAN CARBONIC ANHYDRASE IV AND METHAZOLAMIDE
Descriptor:Carbonic anhydrase 4, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ZINC ION, ...
Authors:Chen, Z., Waheed, A., Di Cera, E., Sly, W.S.
Deposit date:2016-07-12
Release date:2017-07-26
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
1JCZ
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CARBONIC ANHYDRASE XII
Descriptor:CARBONIC ANHYDRASE XII, ZINC ION, ACETIC ACID
Authors:Whittington, D.A., Waheed, A., Ulmasov, B., Shah, G.N., Grubb, J.H., Sly, W.S., Christianson, D.W.
Deposit date:2001-06-11
Release date:2001-08-17
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.
Proc.Natl.Acad.Sci.USA, 98, 2001
1JD0
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CARBONIC ANHYDRASE XII COMPLEXED WITH ACETAZOLAMIDE
Descriptor:CARBONIC ANHYDRASE XII, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
Authors:Whittington, D.A., Waheed, A., Ulmasov, B., Shah, G.N., Grubb, J.H., Sly, W.S., Christianson, D.W.
Deposit date:2001-06-11
Release date:2001-08-17
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.
Proc.Natl.Acad.Sci.USA, 98, 2001
1RJ5
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE CARBONIC ANHYDRASE XIV
Descriptor:Carbonic anhydrase XIV, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Whittington, D.A., Grubb, J.H., Waheed, A., Shah, G.N., Sly, W.S., Christianson, D.W.
Deposit date:2003-11-18
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.
J.Biol.Chem., 279, 2004
1RJ6
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE CARBONIC ANHYDRASE XIV IN COMPLEX WITH ACETAZOLAMIDE
Descriptor:Carbonic anhydrase XIV, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Whittington, D.A., Grubb, J.H., Waheed, A., Shah, G.N., Sly, W.S., Christianson, D.W.
Deposit date:2003-11-18
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.
J.Biol.Chem., 279, 2004
1BHG
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HUMAN BETA-GLUCURONIDASE AT 2.6 A RESOLUTION
Descriptor:BETA-GLUCURONIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Jain, S., Drendel, W.B.
Deposit date:1996-03-04
Release date:1997-09-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs.
Nat.Struct.Biol., 3, 1996
1ZNC
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HUMAN CARBONIC ANHYDRASE IV
Descriptor:CARBONIC ANHYDRASE IV, SULFATE ION, ZINC ION
Authors:Stams, T., Christianson, D.W.
Deposit date:1996-09-17
Release date:1997-09-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution.
Proc.Natl.Acad.Sci.USA, 93, 1996
5IPZ
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME IV WITH 5-(2-AMINO-1,3-THIAZOL-4-YL)-2-CHLOROBENZENESULFONAMIDE
Descriptor:Carbonic anhydrase 4, ZINC ION, 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzene-1-sulfonamide
Authors:Smirnov, A., Manakova, E., Grazulis, S.
Deposit date:2016-03-10
Release date:2017-03-29
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
2ZNC
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MURINE CARBONIC ANHYDRASE IV
Descriptor:CARBONIC ANHYDRASE IV, ZINC ION
Authors:Stams, T., Chen, Y., Christianson, D.W.
Deposit date:1998-02-10
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.
Protein Sci., 7, 1998
3ZNC
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MURINE CARBONIC ANHYDRASE IV COMPLEXED WITH BRINZOLAMIDE
Descriptor:CARBONIC ANHYDRASE IV, ZINC ION, (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE
Authors:Stams, T., Chen, Y., Christianson, D.W.
Deposit date:1998-02-10
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.
Protein Sci., 7, 1998