Author results

1IFB
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REFINED APOPROTEIN STRUCTURE OF RAT INTESTINAL FATTY ACID BINDING PROTEIN PRODUCED IN ESCHERICHIA COLI
Descriptor:INTESTINAL FATTY ACID BINDING PROTEIN
Authors:Sacchettini, J.C., Gordon, J.I., Banaszak, L.J.
Deposit date:1990-12-05
Release date:1992-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli.
Proc.Natl.Acad.Sci.USA, 86, 1989
2IFB
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CRYSTAL STRUCTURE OF RAT INTESTINAL FATTY-ACID-BINDING PROTEIN. REFINEMENT AND ANALYSIS OF THE ESCHERICHIA COLI-DRIVED PROTEIN WITH BOUND PALMITATE
Descriptor:INTESTINAL FATTY ACID BINDING PROTEIN, PALMITIC ACID
Authors:Sacchettini, J.C., Gordon, J.I., Banaszak, L.J.
Deposit date:1990-12-05
Release date:1992-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate.
J.Mol.Biol., 208, 1989
3OKR
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STRUCTURE OF MTB APO 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLTRANSFERASE (ISPD)
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, Heptamer peptide
Authors:Sacchettini, J.C., Reddy, M.C.M., Bruning, J.B., Thurman, C., TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-08-25
Release date:2010-10-06
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Mycobacterium tuberculosis 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD): an antitubercular drug target
To be Published
3F4B
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CRYSTAL STRUCTURE OF PLASMODIUM BERGHEI ENOYL-ACYL-CARRIER-PROTEIN REDUCTASE WITH TRICLOSAN
Descriptor:Enoyl-acyl carrier protein reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN
Authors:Sacchettini, J.C., Tsai, H.-C.
Deposit date:2008-10-31
Release date:2010-03-02
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Cell Host Microbe, 4, 2008
1M1M
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X-RAY CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (MTFABH)
Descriptor:3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III
Authors:Sacchettini, J.C., Sridharan, S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2002-06-19
Release date:2002-07-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
J.Biol.Chem., 280, 2005
2HH7
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CRYSTAL STRUCTURE OF CU(I) BOUND CSOR FROM MYCOBACTERIUM TUBERCULOSIS.
Descriptor:Hypothetical protein CsoR, COPPER (I) ION
Authors:Sacchettini, J.C., Ramesh, A.
Deposit date:2006-06-27
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.
Nat.Chem.Biol., 3, 2007
4XT4
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CRYSTAL STRUCTURE OF RV2671 FROM MYCOBACTEIRUM TUBERCULOSIS IN COMPLEX WITH DIHYDROPTERIDINE RING OF DIHYDROPTEROIC ACID
Descriptor:Rv2671, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-amino-6-methyl-7,8-dihydropteridin-4(3H)-one, ...
Authors:Sacchettini, J.C., Cheng, Y.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-22
Release date:2016-02-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.891 Å)
Cite:Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT5
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CRYSTAL STRUCTURE OF RV2671 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH NADP+
Descriptor:Rv2671, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sacchettini, J.C., Cheng, Y.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-22
Release date:2016-02-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT6
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CRYSTAL STRUCTURE OF RV2671 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE TETRAHYDROPTERIDINE RING OF TETRAHYDROFOLATE (THF)
Descriptor:Rv2671, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (6S)-2-amino-6-methyl-5,6,7,8-tetrahydropteridin-4(3H)-one
Authors:Sacchettini, J.C., Cheng, Y.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-23
Release date:2016-02-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT7
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CRYSTAL STRUCTURE OF RV2671 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH NADP+ AND TRIMETHOPRIM
Descriptor:Rv2671, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM, ...
Authors:Sacchettini, J.C., Cheng, Y.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-23
Release date:2016-02-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT8
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CRYSTAL STRUCTURE OF RV2671 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH NADP+ AND TRIMETREXATE
Descriptor:Rv2671, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETREXATE, ...
Authors:Sacchettini, J.C., Cheng, Y.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-23
Release date:2016-02-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
5KVU
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CRYSTAL STRUCTURE OF ISOCITRATE DEHYDROGENASE-2 IN COMPLEX WITH NADP(+) FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Isocitrate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, D-MALATE, ...
Authors:Cheng, Y.S., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:2016-07-15
Release date:2017-07-19
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural and kinetic characterization of isocitrate dehydrogenase-2 from Mycobacterium tuberculosis
To Be Published
1KZW
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SOLUTION STRUCTURE OF HUMAN INTESTINAL FATTY ACID BINDING PROTEIN
Descriptor:INTESTINAL FATTY ACID-BINDING PROTEIN (A54)
Authors:Zhang, F., Luecke, C., Baier, L.J., Sacchettini, J.C., Hamilton, J.A.
Deposit date:2002-02-08
Release date:2003-07-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism
Biochemistry, 42, 2003
1KZX
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SOLUTION STRUCTURE OF HUMAN INTESTINAL FATTY ACID BINDING PROTEIN WITH A NATURALLY-OCCURRING SINGLE AMINO ACID SUBSTITUTION (A54T)
Descriptor:INTESTINAL FATTY ACID-BINDING PROTEIN (T54)
Authors:Zhang, F., Luecke, C., Baier, L.J., Sacchettini, J.C., Hamilton, J.A.
Deposit date:2002-02-08
Release date:2003-07-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism
Biochemistry, 42, 2003
3IFB
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NMR STUDY OF HUMAN INTESTINAL FATTY ACID BINDING PROTEIN
Descriptor:INTESTINAL FATTY ACID BINDING PROTEIN
Authors:Zhang, F., Luecke, C., Baier, L.J., Sacchettini, J.C., Hamilton, J.A.
Deposit date:1998-10-16
Release date:1998-10-21
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit.
J.Biomol.NMR, 9, 1997
1EIO
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ILEAL LIPID BINDING PROTEIN IN COMPLEX WITH GLYCOCHOLATE
Descriptor:ILEAL LIPID BINDING PROTEIN, GLYCOCHOLIC ACID
Authors:Luecke, C., Zhang, F., Hamilton, J.A., Sacchettini, J.C., Rueterjans, H.
Deposit date:2000-02-27
Release date:2000-05-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of ileal lipid binding protein in complex with glycocholate.
Eur.J.Biochem., 267, 2000
1HMP
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THE CRYSTAL STRUCTURE OF HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH BOUND GMP
Descriptor:HYPOXANTHINE GUANINE PHOSPHORIBOSYL-TRANSFERASE, GUANOSINE-5'-MONOPHOSPHATE
Authors:Eads, J.C., Scapin, G., Xu, Y., Grubmeyer, C., Sacchettini, J.C.
Deposit date:1994-06-03
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP.
Cell(Cambridge,Mass.), 78, 1994
5C7V
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 1H-PYRROLE-2-CARBOXYLIC ACID
Descriptor:Malate synthase G, MAGNESIUM ION, PYRROLE-2-CARBOXYLATE
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-25
Release date:2016-08-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.504 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5C9R
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 3-((4-CHLOROPHENYL)THIO)PROPANOIC ACID
Descriptor:Malate synthase G, MAGNESIUM ION, 3-[(4-chlorophenyl)sulfanyl]propanoic acid
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-28
Release date:2016-07-27
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5C9U
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 2-(2-(2,4-DICHLOROPHENYL)HYDRAZINYL)-2-OXOACETIC ACID
Descriptor:Malate synthase G, MAGNESIUM ION, [2-(2,4-dichlorophenyl)hydrazinyl](oxo)acetic acid
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-29
Release date:2016-08-10
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5C9W
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH (Z)-N-(2-BROMOPHENYL)-2-(HYDROXYIMINO)ACETAMIDE
Descriptor:Malate synthase G, MAGNESIUM ION, (2E)-N-(2-bromophenyl)-2-(hydroxyimino)acetamide
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-29
Release date:2016-08-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.0928 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5C9X
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 2,4-DICHLORO-5-FLUOROBENZOIC ACID
Descriptor:Malate synthase G, MAGNESIUM ION, 2,4-dichloro-5-fluorobenzoic acid
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-29
Release date:2016-08-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5CAH
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID
Descriptor:Malate synthase G, MAGNESIUM ION, 6H-thieno[2,3-b]pyrrole-5-carboxylic acid
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-29
Release date:2016-08-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5CBB
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 5-(3H-INDOL-3-YLIDENE)-2,5-DIHYDRO-1H-PYRAZOLE-3-CARBOXYLATE
Descriptor:Malate synthase G, MAGNESIUM ION, (5E)-5-(3H-indol-3-ylidene)-2,5-dihydro-1H-pyrazole-3-carboxylic acid
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-30
Release date:2016-08-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.012 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5CBI
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 5-CHLORO-2-HYDROXYBENZONITRILE
Descriptor:Malate synthase G, MAGNESIUM ION, 5-chloro-2-hydroxybenzonitrile
Authors:Huang, H.-L., Sacchettini, J.C.
Deposit date:2015-06-30
Release date:2016-08-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.988 Å)
Cite:Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016