5W3D | | THE STRUCTURE OF KINESIN-14 WILD-TYPE NCD-ADP DIMER | | Descriptor: | Protein claret segregational, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE | | Authors: | Park, H.W., Ma, Z., Chacko, J., Jiang, S.M., Robinson, R.C., Endow, S.A. | | Deposit date: | 2017-06-07 | | Release date: | 2017-12-20 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Sci Rep, 7, 2017
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1DC3 | |
1ESM | | STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A | | Descriptor: | PANTOTHENATE KINASE, COENZYME A | | Authors: | Yun, M., Park, C.G., Kim, J.Y., Rock, C.O., Jackowski, S., Park, H.W. | | Deposit date: | 2000-04-10 | | Release date: | 2000-09-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
J.Biol.Chem., 275, 2000
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1ESN | | STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A | | Descriptor: | PANTOTHENATE KINASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Yun, M., Park, C.G., Kim, J.Y., Rock, C.O., Jackowski, S., Park, H.W. | | Deposit date: | 2000-04-10 | | Release date: | 2000-11-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
J.Biol.Chem., 275, 2000
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1F9U | | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | | Descriptor: | KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE | | Authors: | Yun, M., Zhang, X., Park, C.G., Park, H.W., Endow, S.A. | | Deposit date: | 2000-07-11 | | Release date: | 2001-06-13 | | Last modified: | 2017-02-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
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1F9V | | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | | Descriptor: | KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE | | Authors: | Yun, M., Zhang, X., Park, C.G., Park, H.W., Endow, S.A. | | Deposit date: | 2000-07-11 | | Release date: | 2001-06-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
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1F9W | | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | | Descriptor: | KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE | | Authors: | Yun, M., Zhang, X., Park, C.G., Park, H.W., Endow, S.A. | | Deposit date: | 2000-07-11 | | Release date: | 2001-06-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
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1P3R | | CRYSTAL STRUCTURE OF THE PHOSPHOTYROSIN BINDING DOMAIN(PTB) OF MOUSE DISABLED 1(DAB1) | | Descriptor: | Disabled homolog 2 | | Authors: | Yun, M., Keshvara, L., Park, C.G., Zhang, Y.M., Dickerson, J.B., Zheng, J., Rock, C.O., Curran, T., Park, H.W. | | Deposit date: | 2003-04-18 | | Release date: | 2003-08-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
J.Biol.Chem., 278, 2003
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1RR7 | |
1ZNQ | | CRYSTAL STRUCTURE OF HUMAN LIVER GAPDH | | Descriptor: | Glyceraldehyde-3-phosphate dehydrogenase, liver, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Ismail, S.A., Park, H.W. | | Deposit date: | 2005-05-11 | | Release date: | 2005-05-24 | | Last modified: | 2019-01-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure Analysis of Human liver GAPDH
To be Published
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2A5J | | CRYSTAL STRUCTURE OF HUMAN RAB2B | | Descriptor: | Ras-related protein Rab-2B, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Dong, A., Wang, J., Shen, Y., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-06-30 | | Release date: | 2005-07-19 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.501 Å) | | Cite: | Crystal structure of human RAB2B
To be Published
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2EW1 | | CRYSTAL STRUCTURE OF RAB30 IN COMPLEX WITH A GTP ANALOGUE | | Descriptor: | Ras-related protein Rab-30, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | Authors: | Wang, J., Shen, Y., Ismail, S., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-11-01 | | Release date: | 2005-11-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of RAB30 in complex with a GTP analogue
To be Published
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2EWS | |
2F7S | | THE CRYSTAL STRUCTURE OF HUMAN RAB27B BOUND TO GDP | | Descriptor: | Ras-related protein Rab-27B, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Wang, J., Ismail, S., Shen, Y., Tempel, W., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-12-01 | | Release date: | 2005-12-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The crystal structure of human Rab27b
To be Published
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2FSE | | CRYSTALLOGRAPHIC STRUCTURE OF A RHEUMATOID ARTHRITIS MHC SUSCEPTIBILITY ALLELE, HLA-DR1 (DRB1*0101), COMPLEXED WITH THE IMMUNODOMINANT DETERMINANT OF HUMAN TYPE II COLLAGEN | | Descriptor: | H-2 class II histocompatibility antigen, E-K alpha chain, HLA class II histocompatibility antigen, ... | | Authors: | Ivey, R.A., Rosloniec, E.F., Whittington, K.B., Kang, A.H., Park, H.W. | | Deposit date: | 2006-01-22 | | Release date: | 2006-09-19 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Crystallographic Structure of a Rheumatoid Arthritis MHC Susceptibility Allele, HLA-DR1 (DRB1*0101), Complexed with the Immunodominant Determinant of Human Type II Collagen.
J.Immunol., 177, 2006
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2I7N | | CRYSTAL STRUCTURE OF HUMAN PANK1 ALPHA: THE CATALYTIC CORE DOMAIN IN COMPLEX WITH ACCOA | | Descriptor: | Pantothenate kinase 1, ACETYL COENZYME *A | | Authors: | Hong, B.S., Wang, L., Tempel, W., Loppnau, P., Allali-Hassani, A., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H.W. | | Deposit date: | 2006-08-31 | | Release date: | 2006-12-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
J.Biol.Chem., 282, 2007
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2I7P | | CRYSTAL STRUCTURE OF HUMAN PANK3 IN COMPLEX WITH ACCOA | | Descriptor: | Pantothenate kinase 3, ACETYL COENZYME *A | | Authors: | Hong, B.S., Wang, L., Shen, L., Tempel, W., Loppnau, P., Finerty, P., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-08-31 | | Release date: | 2006-12-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
J.Biol.Chem., 282, 2007
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2OSA | | THE RHO-GAP DOMAIN OF HUMAN N-CHIMAERIN | | Descriptor: | N-chimaerin | | Authors: | Walker, J.R., Hong, B.S., Shen, L., Arrowsmith, C.H., Sundstrom, M., Weigelt, J., Edwards, A.M., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-02-05 | | Release date: | 2007-03-06 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the Rho-GAP domain from human N-chimaerin
To be Published
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3FEG | | CRYSTAL STRUCTURE OF HUMAN CHOLINE KINASE BETA IN COMPLEX WITH PHOSPHORYLATED HEMICHOLINIUM-3 AND ADENOSINE NUCLEOTIDE | | Descriptor: | Choline/ethanolamine kinase, (2S)-2-[4'-({dimethyl[2-(phosphonooxy)ethyl]ammonio}acetyl)biphenyl-4-yl]-2-hydroxy-4,4-dimethylmorpholin-4-ium, SULFATE ION, ... | | Authors: | Hong, B.S., Tempel, W., Rabeh, W.M., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC) | | Deposit date: | 2008-11-29 | | Release date: | 2008-12-23 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.302 Å) | | Cite: | Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J.Biol.Chem., 285, 2010
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3G15 | | CRYSTAL STRUCTURE OF HUMAN CHOLINE KINASE ALPHA IN COMPLEX WITH HEMICHOLINIUM-3 AND ADP | | Descriptor: | Choline kinase alpha, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Hong, B.S., Tempel, W., Rabeh, W.M., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC) | | Deposit date: | 2009-01-29 | | Release date: | 2009-02-10 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J.Biol.Chem., 285, 2010
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3LQ3 | | CRYSTAL STRUCTURE OF HUMAN CHOLINE KINASE BETA IN COMPLEX WITH PHOSPHORYLATED HEMICHOLINIUM-3 AND ADENOSINE NUCLEOTIDE | | Descriptor: | Choline/ethanolamine kinase, (2S)-2-[4'-({dimethyl[2-(phosphonooxy)ethyl]ammonio}acetyl)biphenyl-4-yl]-2-hydroxy-4,4-dimethylmorpholin-4-ium, MAGNESIUM ION, ... | | Authors: | Hong, B.S., Tempel, W., Rabeh, W.M., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC) | | Deposit date: | 2010-02-08 | | Release date: | 2010-05-05 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J.Biol.Chem., 285, 2010
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4F7W | | CRYSTAL STRUCTURE OF KLEBSIELLA PNEUMONIAE PANTOTHENATE KINASE IN COMPLEX WITH N-PENTYLPANTOTHENAMIDE | | Descriptor: | Pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide, ... | | Authors: | Li, B., Tempel, W., Smil, D., Bolshan, Y., Hong, B.S., Park, H.W., Structural Genomics Consortium (SGC) | | Deposit date: | 2012-05-16 | | Release date: | 2013-04-10 | | Last modified: | 2013-08-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.
Proteins, 81, 2013
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4FXQ | | FULL-LENGTH CERTHRAX TOXIN FROM BACILLUS CEREUS IN COMPLEX WITH INHIBITOR P6 | | Descriptor: | Putative ADP-ribosyltransferase Certhrax, 8-fluoro-2-(3-piperidin-1-ylpropanoyl)-1,3,4,5-tetrahydrobenzo[c][1,6]naphthyridin-6(2H)-one, CHLORIDE ION, ... | | Authors: | Visschedyk, D.D., Dimov, S., Kimber, M.S., Park, H.W., Merrill, A.R. | | Deposit date: | 2012-07-03 | | Release date: | 2012-09-26 | | Last modified: | 2012-12-19 | | Method: | X-RAY DIFFRACTION (1.9599 Å) | | Cite: | Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
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4GI7 | | CRYSTAL STRUCTURE OF KLEBSIELLA PNEUMONIAE PANTOTHENATE KINASE IN COMPLEX WITH A PANTOTHENATE ANALOGUE | | Descriptor: | Pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, (2R)-2,4-dihydroxy-3,3-dimethyl-N-{3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl}butanamide, ... | | Authors: | Li, B., Tempel, W., Smil, D., Bolshan, Y., Hong, B.S., Park, H.W., Structural Genomics Consortium (SGC) | | Deposit date: | 2012-08-08 | | Release date: | 2013-04-10 | | Last modified: | 2013-08-07 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.
Proteins, 81, 2013
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4NB4 | | PANTOTHENAMIDE-BOUND PANTOTHENATE KINASE FROM STAPHYLOCOCCUS AUREUS | | Descriptor: | Type II pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, N-[2-(1,3-benzodioxol-5-yl)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... | | Authors: | Hughes, S.J., Antoshchenko, T., Smil, D., Park, H.W. | | Deposit date: | 2013-10-22 | | Release date: | 2014-03-05 | | Last modified: | 2014-06-25 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus.
Proteins, 82, 2014
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