Author results

5W3D
  • Download 5w3d
  • View 5w3d
Molmil generated image of 5w3d
THE STRUCTURE OF KINESIN-14 WILD-TYPE NCD-ADP DIMER
Descriptor:Protein claret segregational, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Park, H.W., Ma, Z., Chacko, J., Jiang, S.M., Robinson, R.C., Endow, S.A.
Deposit date:2017-06-07
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Sci Rep, 7, 2017
1DC3
  • Download 1dc3
  • View 1dc3
Molmil generated image of 1dc3
STRUCTURAL ANALYSIS OF GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FROM ESCHERICHIA COLI: DIRECT EVIDENCE FOR SUBSTRATE BINDING AND COFACTOR-INDUCED CONFORMATIONAL CHANGES
Descriptor:GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE
Authors:Yun, M., Park, C.G., Kim, J.Y., Park, H.W.
Deposit date:1999-11-04
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli: direct evidence of substrate binding and cofactor-induced conformational changes.
Biochemistry, 39, 2000
1ESM
  • Download 1esm
  • View 1esm
Molmil generated image of 1esm
STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A
Descriptor:PANTOTHENATE KINASE, COENZYME A
Authors:Yun, M., Park, C.G., Kim, J.Y., Rock, C.O., Jackowski, S., Park, H.W.
Deposit date:2000-04-10
Release date:2000-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
J.Biol.Chem., 275, 2000
1ESN
  • Download 1esn
  • View 1esn
Molmil generated image of 1esn
STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A
Descriptor:PANTOTHENATE KINASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Yun, M., Park, C.G., Kim, J.Y., Rock, C.O., Jackowski, S., Park, H.W.
Deposit date:2000-04-10
Release date:2000-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
J.Biol.Chem., 275, 2000
1F9U
  • Download 1f9u
  • View 1f9u
Molmil generated image of 1f9u
CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE
Descriptor:KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Yun, M., Zhang, X., Park, C.G., Park, H.W., Endow, S.A.
Deposit date:2000-07-11
Release date:2001-06-13
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
1F9V
  • Download 1f9v
  • View 1f9v
Molmil generated image of 1f9v
CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE
Descriptor:KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Yun, M., Zhang, X., Park, C.G., Park, H.W., Endow, S.A.
Deposit date:2000-07-11
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
1F9W
  • Download 1f9w
  • View 1f9w
Molmil generated image of 1f9w
CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE
Descriptor:KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Yun, M., Zhang, X., Park, C.G., Park, H.W., Endow, S.A.
Deposit date:2000-07-11
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A structural pathway for activation of the kinesin motor ATPase.
EMBO J., 20, 2001
1P3R
  • Download 1p3r
  • View 1p3r
Molmil generated image of 1p3r
CRYSTAL STRUCTURE OF THE PHOSPHOTYROSIN BINDING DOMAIN(PTB) OF MOUSE DISABLED 1(DAB1)
Descriptor:Disabled homolog 2
Authors:Yun, M., Keshvara, L., Park, C.G., Zhang, Y.M., Dickerson, J.B., Zheng, J., Rock, C.O., Curran, T., Park, H.W.
Deposit date:2003-04-18
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
J.Biol.Chem., 278, 2003
1RR7
  • Download 1rr7
  • View 1rr7
Molmil generated image of 1rr7
CRYSTAL STRUCTURE OF THE MIDDLE OPERON REGULATOR PROTEIN OF BACTERIOPHAGE MU
Descriptor:Middle operon regulator, PLATINUM (II) ION
Authors:Kumaraswami, M., Howe, M.M., Park, H.W.
Deposit date:2003-12-08
Release date:2004-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the Mor protein of bacteriophage Mu, a member of the Mor/C family of transcription activators.
J.Biol.Chem., 279, 2004
1ZNQ
  • Download 1znq
  • View 1znq
Molmil generated image of 1znq
CRYSTAL STRUCTURE OF HUMAN LIVER GAPDH
Descriptor:Glyceraldehyde-3-phosphate dehydrogenase, liver, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Ismail, S.A., Park, H.W.
Deposit date:2005-05-11
Release date:2005-05-24
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure Analysis of Human liver GAPDH
To be Published
2A5J
  • Download 2a5j
  • View 2a5j
Molmil generated image of 2a5j
CRYSTAL STRUCTURE OF HUMAN RAB2B
Descriptor:Ras-related protein Rab-2B, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Dong, A., Wang, J., Shen, Y., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2005-06-30
Release date:2005-07-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Crystal structure of human RAB2B
To be Published
2EW1
  • Download 2ew1
  • View 2ew1
Molmil generated image of 2ew1
CRYSTAL STRUCTURE OF RAB30 IN COMPLEX WITH A GTP ANALOGUE
Descriptor:Ras-related protein Rab-30, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Wang, J., Shen, Y., Ismail, S., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2005-11-01
Release date:2005-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of RAB30 in complex with a GTP analogue
To be Published
2EWS
  • Download 2ews
  • View 2ews
Molmil generated image of 2ews
CRYSTAL STRUCTURE OF S.AUREUS PANTOTHENATE KINASE
Descriptor:Pantothenate kinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Hong, B.S., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2005-11-06
Release date:2006-09-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Prokaryotic Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties.
Structure, 14, 2006
2F7S
  • Download 2f7s
  • View 2f7s
Molmil generated image of 2f7s
THE CRYSTAL STRUCTURE OF HUMAN RAB27B BOUND TO GDP
Descriptor:Ras-related protein Rab-27B, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Wang, J., Ismail, S., Shen, Y., Tempel, W., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2005-12-01
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of human Rab27b
To be Published
2FSE
  • Download 2fse
  • View 2fse
Molmil generated image of 2fse
CRYSTALLOGRAPHIC STRUCTURE OF A RHEUMATOID ARTHRITIS MHC SUSCEPTIBILITY ALLELE, HLA-DR1 (DRB1*0101), COMPLEXED WITH THE IMMUNODOMINANT DETERMINANT OF HUMAN TYPE II COLLAGEN
Descriptor:H-2 class II histocompatibility antigen, E-K alpha chain, HLA class II histocompatibility antigen, ...
Authors:Ivey, R.A., Rosloniec, E.F., Whittington, K.B., Kang, A.H., Park, H.W.
Deposit date:2006-01-22
Release date:2006-09-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystallographic Structure of a Rheumatoid Arthritis MHC Susceptibility Allele, HLA-DR1 (DRB1*0101), Complexed with the Immunodominant Determinant of Human Type II Collagen.
J.Immunol., 177, 2006
2I7N
  • Download 2i7n
  • View 2i7n
Molmil generated image of 2i7n
CRYSTAL STRUCTURE OF HUMAN PANK1 ALPHA: THE CATALYTIC CORE DOMAIN IN COMPLEX WITH ACCOA
Descriptor:Pantothenate kinase 1, ACETYL COENZYME *A
Authors:Hong, B.S., Wang, L., Tempel, W., Loppnau, P., Allali-Hassani, A., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H.W.
Deposit date:2006-08-31
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
J.Biol.Chem., 282, 2007
2I7P
  • Download 2i7p
  • View 2i7p
Molmil generated image of 2i7p
CRYSTAL STRUCTURE OF HUMAN PANK3 IN COMPLEX WITH ACCOA
Descriptor:Pantothenate kinase 3, ACETYL COENZYME *A
Authors:Hong, B.S., Wang, L., Shen, L., Tempel, W., Loppnau, P., Finerty, P., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2006-08-31
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
J.Biol.Chem., 282, 2007
2OSA
  • Download 2osa
  • View 2osa
Molmil generated image of 2osa
THE RHO-GAP DOMAIN OF HUMAN N-CHIMAERIN
Descriptor:N-chimaerin
Authors:Walker, J.R., Hong, B.S., Shen, L., Arrowsmith, C.H., Sundstrom, M., Weigelt, J., Edwards, A.M., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2007-02-05
Release date:2007-03-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Rho-GAP domain from human N-chimaerin
To be Published
3FEG
  • Download 3feg
  • View 3feg
Molmil generated image of 3feg
CRYSTAL STRUCTURE OF HUMAN CHOLINE KINASE BETA IN COMPLEX WITH PHOSPHORYLATED HEMICHOLINIUM-3 AND ADENOSINE NUCLEOTIDE
Descriptor:Choline/ethanolamine kinase, (2S)-2-[4'-({dimethyl[2-(phosphonooxy)ethyl]ammonio}acetyl)biphenyl-4-yl]-2-hydroxy-4,4-dimethylmorpholin-4-ium, SULFATE ION, ...
Authors:Hong, B.S., Tempel, W., Rabeh, W.M., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2008-11-29
Release date:2008-12-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.302 Å)
Cite:Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J.Biol.Chem., 285, 2010
3G15
  • Download 3g15
  • View 3g15
Molmil generated image of 3g15
CRYSTAL STRUCTURE OF HUMAN CHOLINE KINASE ALPHA IN COMPLEX WITH HEMICHOLINIUM-3 AND ADP
Descriptor:Choline kinase alpha, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Hong, B.S., Tempel, W., Rabeh, W.M., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2009-01-29
Release date:2009-02-10
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J.Biol.Chem., 285, 2010
3LQ3
  • Download 3lq3
  • View 3lq3
Molmil generated image of 3lq3
CRYSTAL STRUCTURE OF HUMAN CHOLINE KINASE BETA IN COMPLEX WITH PHOSPHORYLATED HEMICHOLINIUM-3 AND ADENOSINE NUCLEOTIDE
Descriptor:Choline/ethanolamine kinase, (2S)-2-[4'-({dimethyl[2-(phosphonooxy)ethyl]ammonio}acetyl)biphenyl-4-yl]-2-hydroxy-4,4-dimethylmorpholin-4-ium, MAGNESIUM ION, ...
Authors:Hong, B.S., Tempel, W., Rabeh, W.M., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2010-02-08
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J.Biol.Chem., 285, 2010
4F7W
  • Download 4f7w
  • View 4f7w
Molmil generated image of 4f7w
CRYSTAL STRUCTURE OF KLEBSIELLA PNEUMONIAE PANTOTHENATE KINASE IN COMPLEX WITH N-PENTYLPANTOTHENAMIDE
Descriptor:Pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide, ...
Authors:Li, B., Tempel, W., Smil, D., Bolshan, Y., Hong, B.S., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2012-05-16
Release date:2013-04-10
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.
Proteins, 81, 2013
4FXQ
  • Download 4fxq
  • View 4fxq
Molmil generated image of 4fxq
FULL-LENGTH CERTHRAX TOXIN FROM BACILLUS CEREUS IN COMPLEX WITH INHIBITOR P6
Descriptor:Putative ADP-ribosyltransferase Certhrax, 8-fluoro-2-(3-piperidin-1-ylpropanoyl)-1,3,4,5-tetrahydrobenzo[c][1,6]naphthyridin-6(2H)-one, CHLORIDE ION, ...
Authors:Visschedyk, D.D., Dimov, S., Kimber, M.S., Park, H.W., Merrill, A.R.
Deposit date:2012-07-03
Release date:2012-09-26
Last modified:2012-12-19
Method:X-RAY DIFFRACTION (1.9599 Å)
Cite:Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
4GI7
  • Download 4gi7
  • View 4gi7
Molmil generated image of 4gi7
CRYSTAL STRUCTURE OF KLEBSIELLA PNEUMONIAE PANTOTHENATE KINASE IN COMPLEX WITH A PANTOTHENATE ANALOGUE
Descriptor:Pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, (2R)-2,4-dihydroxy-3,3-dimethyl-N-{3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl}butanamide, ...
Authors:Li, B., Tempel, W., Smil, D., Bolshan, Y., Hong, B.S., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2012-08-08
Release date:2013-04-10
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.
Proteins, 81, 2013
4NB4
  • Download 4nb4
  • View 4nb4
Molmil generated image of 4nb4
PANTOTHENAMIDE-BOUND PANTOTHENATE KINASE FROM STAPHYLOCOCCUS AUREUS
Descriptor:Type II pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, N-[2-(1,3-benzodioxol-5-yl)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ...
Authors:Hughes, S.J., Antoshchenko, T., Smil, D., Park, H.W.
Deposit date:2013-10-22
Release date:2014-03-05
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus.
Proteins, 82, 2014