Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP

Summary for 5F1X

Related5EVZ 5EX5 5EXW 5EY4 5F0X 5F2R
Descriptor78 kDa glucose-regulated protein, ADENOSINE-5'-TRIPHOSPHATE (3 entities in total)
Functional Keywordschaperone, atpase domain, nucleotide-binding, endoplasmic reticulum
Biological sourceHomo sapiens (Human)
Cellular locationEndoplasmic reticulum lumen P11021
Total number of polymer chains2
Total molecular weight89726.54
Hughes, S.J.,Antoshchenko, T.,Song, J.H.,Pizarro, J.,Park, H.W. (deposition date: 2015-11-30, release date: 2016-06-15)
Primary citation
Hughes, S.J.,Antoshchenko, T.,Chen, Y.,Lu, H.,Pizarro, J.C.,Park, H.W.
Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs.
Plos One, 11:e0154862-e0154862, 2016
PubMed: 27144892 (PDB entries with the same primary citation)
DOI: 10.1371/journal.pone.0154862
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.234200 2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28