Author results

1KLT
  • Download 1klt
  • View 1klt
Molmil generated image of 1klt
CRYSTAL STRUCTURE OF PMSF-TREATED HUMAN CHYMASE AT 1.9 ANGSTROMS RESOLUTION
Descriptor:CHYMASE, phenylmethanesulfonic acid
Authors:Mcgrath, M.E.
Deposit date:1997-10-16
Release date:1998-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A.
Biochemistry, 36, 1997
1MEM
  • Download 1mem
  • View 1mem
Molmil generated image of 1mem
CRYSTAL STRUCTURE OF CATHEPSIN K COMPLEXED WITH A POTENT VINYL SULFONE INHIBITOR
Descriptor:Cathepsin K, N-{(1R)-3-phenyl-1-[2-(phenylsulfonyl)ethyl]propyl}-N~2~-(piperazin-1-ylcarbonyl)-L-leucinamide
Authors:Mcgrath, M.E.
Deposit date:1997-01-08
Release date:1998-01-14
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human cathepsin K complexed with a potent inhibitor.
Nat.Struct.Biol., 4, 1997
1ANB
  • Download 1anb
  • View 1anb
Molmil generated image of 1anb
ANIONIC TRYPSIN MUTANT WITH SER 214 REPLACED BY GLU
Descriptor:ANIONIC TRYPSIN, CALCIUM ION, BENZAMIDINE
Authors:Fletterick, R.J., Mcgrath, M.E.
Deposit date:1994-12-21
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214.
Biochemistry, 31, 1992
1ANC
  • Download 1anc
  • View 1anc
Molmil generated image of 1anc
ANIONIC TRYPSIN MUTANT WITH SER 214 REPLACED BY LYS
Descriptor:ANIONIC TRYPSIN, CALCIUM ION, BENZAMIDINE
Authors:Fletterick, R.J., Mcgrath, M.E.
Deposit date:1994-12-21
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214.
Biochemistry, 31, 1992
1AND
  • Download 1and
  • View 1and
Molmil generated image of 1and
ANIONIC TRYPSIN MUTANT WITH ARG 96 REPLACED BY HIS
Descriptor:ANIONIC TRYPSIN, COPPER (II) ION, BENZAMIDINE
Authors:Fletterick, R.J., Mcgrath, M.E.
Deposit date:1994-12-21
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of an engineered, metal-actuated switch in trypsin.
Biochemistry, 32, 1993
1ANE
  • Download 1ane
  • View 1ane
Molmil generated image of 1ane
ANIONIC TRYPSIN WILD TYPE
Descriptor:ANIONIC TRYPSIN, BENZAMIDINE
Authors:Fletterick, R.J., Mcgrath, M.E.
Deposit date:1994-12-21
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of an engineered, metal-actuated switch in trypsin.
Biochemistry, 32, 1993
1BRA
  • Download 1bra
  • View 1bra
Molmil generated image of 1bra
RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
Descriptor:TRYPSIN, CALCIUM ION, BENZAMIDINE
Authors:Perona, J.J., Mcgrath, M.E., Fletterick, R.J.
Deposit date:1992-12-17
Release date:1994-04-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Relocating a negative charge in the binding pocket of trypsin.
J.Mol.Biol., 230, 1993
1O5A
  • Download 1o5a
  • View 1o5a
Molmil generated image of 1o5a
DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Urokinase-type plasminogen activator, 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-1,1'-BIPHENYL-2-OLATE, CITRIC ACID
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA)
J.Mol.Biol., 344, 2004
1O5B
  • Download 1o5b
  • View 1o5b
Molmil generated image of 1o5b
DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Urokinase-type plasminogen activator, 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE, CITRIC ACID
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA)
J.Mol.Biol., 344, 2004
1O5C
  • Download 1o5c
  • View 1o5c
Molmil generated image of 1o5c
DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Urokinase-type plasminogen activator, 2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE, CITRIC ACID
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA)
J.Mol.Biol., 344, 2004
1O5D
  • Download 1o5d
  • View 1o5d
Molmil generated image of 1o5d
DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Coagulation factor VII, Tissue factor, 2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
J.Mol.Biol., 344, 2004
1O5E
  • Download 1o5e
  • View 1o5e
Molmil generated image of 1o5e
DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Serine protease hepsin, 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
J.Mol.Biol., 344, 2004
1O5F
  • Download 1o5f
  • View 1o5f
Molmil generated image of 1o5f
DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Serine protease hepsin, 2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
J.Mol.Biol., 344, 2004
1O5G
  • Download 1o5g
  • View 1o5g
Molmil generated image of 1o5g
DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Prothrombin, Hirudin IIIB', SODIUM ION, ...
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
J.Mol.Biol., 344, 2004
1P57
  • Download 1p57
  • View 1p57
Molmil generated image of 1p57
EXTRACELLULAR DOMAIN OF HUMAN HEPSIN
Descriptor:Serine protease hepsin, 2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}BENZENOLATE
Authors:Somoza, J.R., Ho, J.D., Luong, C., Sprengeler, P.A., Mortara, K., Shrader, W.D., Sperandio, D., Chan, H., McGrath, M.E., Katz, B.A.
Deposit date:2003-04-25
Release date:2004-01-20
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain
Structure, 11, 2003
4WTF
  • Download 4wtf
  • View 4wtf
Molmil generated image of 4wtf
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GS-639475, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU
Descriptor:RNA PRIMER TEMPLATE CAAAAUUU, RNA-directed RNA polymerase, MANGANESE (II) ION, ...
Authors:Edwards, T.E., Appleby, T.C., Mcgrath, M.E.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
2FPZ
  • Download 2fpz
  • View 2fpz
Molmil generated image of 2fpz
HUMAN TRYPTASE WITH 2-AMINO BENZIMIDAZOLE
Descriptor:Tryptase beta-2, 2H-BENZOIMIDAZOL-2-YLAMINE
Authors:Somoza, J.R.
Deposit date:2006-01-17
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
2FS8
  • Download 2fs8
  • View 2fs8
Molmil generated image of 2fs8
HUMAN BETA-TRYPTASE II WITH INHIBITOR CRA-29382
Descriptor:Tryptase beta-2, ALLYL {(1S)-1-[(5-{4-[(2,3-DIHYDRO-1H-INDEN-2-YLAMINO)CARBONYL]BENZYL}-1,2,4-OXADIAZOL-3-YL)CARBONYL]-3-PYRROLIDIN-3-YLPROPYL}CARBAMATE
Authors:Somoza, J.R.
Deposit date:2006-01-21
Release date:2006-03-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
2FS9
  • Download 2fs9
  • View 2fs9
Molmil generated image of 2fs9
HUMAN BETA TRYPTASE II WITH INHIBITOR CRA-28427
Descriptor:Tryptase beta-2, ETHYL {(1S)-5-AMINO-1-[(5-{4-[(2,3-DIHYDRO-1H-INDEN-2-YLAMINO)CARBONYL]BENZYL}-1,2,4-OXADIAZOL-3-YL)CARBONYL]PENTYL}CARBAMATE
Authors:Somoza, J.R.
Deposit date:2006-01-21
Release date:2006-03-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
2FWW
  • Download 2fww
  • View 2fww
Molmil generated image of 2fww
HUMAN BETA-TRYPTASE II COMPLEXED WITH 4-PIPERIDINEBUTYRATE TO MAKE ACYLENZYME
Descriptor:Tryptase beta-2, 4-PIPERIDINEBUTYRATE
Authors:Katz, B.A.
Deposit date:2006-02-03
Release date:2006-02-14
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
2FX4
  • Download 2fx4
  • View 2fx4
Molmil generated image of 2fx4
BOVINE TRYPSIN BOUND BY 4-PIPERIDINEBUTYRATE TO MAKE ACYLENZYME COMPLEX
Descriptor:trypsin, CALCIUM ION, 4-PIPERIDINEBUTYRATE
Authors:Katz, B.A.
Deposit date:2006-02-03
Release date:2006-02-14
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
2FX6
  • Download 2fx6
  • View 2fx6
Molmil generated image of 2fx6
BOVINE TRYPSIN COMPLEXED WITH 2-AMINOBENZAMIDAZOLE
Descriptor:Trypsin, CALCIUM ION, 2H-BENZOIMIDAZOL-2-YLAMINE
Authors:Katz, B.A.
Deposit date:2006-02-03
Release date:2006-02-14
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
2FXR
  • Download 2fxr
  • View 2fxr
Molmil generated image of 2fxr
HUMAN BETA TRYPTASE II COMPLEXED WITH ACTIVATED KETONE INHIBITOR CRA-29382
Descriptor:Tryptase beta-2, ALLYL {(1S)-1-[(5-{4-[(2,3-DIHYDRO-1H-INDEN-2-YLAMINO)CARBONYL]BENZYL}-1,2,4-OXADIAZOL-3-YL)CARBONYL]-3-PYRROLIDIN-3-YLPROPYL}CARBAMATE
Authors:Katz, B.A.
Deposit date:2006-02-06
Release date:2006-02-09
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
1VSN
  • Download 1vsn
  • View 1vsn
Molmil generated image of 1vsn
CRYSTAL STRUCTURE OF A POTENT SMALL MOLECULE INHIBITOR BOUND TO CATHEPSIN K
Descriptor:Cathepsin K, N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE
Authors:McGrath, M.
Deposit date:2007-03-19
Release date:2007-04-24
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of a potent and selective non-basic cathepsin K inhibitor.
Bioorg.Med.Chem.Lett., 16, 2006
2ANW
  • Download 2anw
  • View 2anw
Molmil generated image of 2anw
EXPRESSION, CRYSTALLIZATION AND THREE-DIMENSIONAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMA KALLIKREIN: IMPLICATIONS FOR STRUCTURE-BASED DESIGN OF PROTEASE INHIBITORS
Descriptor:plasma kallikrein, light chain, BENZAMIDINE
Authors:Tang, J., Yu, C.L., Williams, S.R., Springman, E., Jeffery, D., Sprengeler, P.A., Estevez, A., Sampang, J., Shrader, W., Spencer, J.R., Young, W.B., McGrath, M.E., Katz, B.A.
Deposit date:2005-08-11
Release date:2005-10-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.
J.Biol.Chem., 280, 2005
<123>