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1O5B

Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)

Summary for 1O5B
Entry DOI10.2210/pdb1o5b/pdb
Related1gjc
DescriptorUrokinase-type plasminogen activator, 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE, CITRIC ACID, ... (5 entities in total)
Functional Keywordsala190 upa, s1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor viia, blood clotting, hydrolase
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P00749 P00749
Total number of polymer chains2
Total formula weight32007.13
Authors
Primary citationKatz, B.A.,Luong, C.,Ho, J.D.,Somoza, J.R.,Gjerstad, E.,Tang, J.,Williams, S.R.,Verner, E.,Mackman, R.L.,Young, W.B.,Sprengeler, P.A.,Chan, H.,Mortara, K.,Janc, J.W.,McGrath, M.E.
Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA)
J.Mol.Biol., 344:527-547, 2004
Cited by
PubMed: 15522303
DOI: 10.1016/j.jmb.2004.09.032
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

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