1O5B
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Urokinase-type plasminogen activator | polymer | 23 | 2708.2 | 1 | UniProt (P00749) In PDB | Homo sapiens (human) | uPA, U-plasminogen activator |
| 2 | B | Urokinase-type plasminogen activator | polymer | 253 | 28419.4 | 1 | UniProt (P00749) Pfam (PF00089) In PDB | Homo sapiens (human) | uPA, U-plasminogen activator |
| 3 | B | 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE | non-polymer | 303.1 | 1 | Chemie (ESI) | |||
| 4 | B | CITRIC ACID | non-polymer | 192.1 | 3 | Chemie (CIT) | |||
| 5 | water | water | 18.0 | 319 | Chemie (HOH) |
Sequence modifications
B: 16 - 250 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 145 | Asn 322 | engineered mutation |
| Ala 190 | Ser 371 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31127.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 879.5 | |
| All* | Total formula weight | 32007.1 |
