2FPZ

Human tryptase with 2-amino benzimidazole

Summary for 2FPZ

• Entry DOI: 10.2210/pdb2fpz/pdb
• Descriptor: Tryptase beta-2, 2H-BENZOIMIDAZOL-2-YLAMINE (3 entities in total)
• Functional Keywords: serine protease, drug design, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P20231
• Total number of polymer chains: 4
• Total formula weight: 110498.31

Authors

Somoza, J.R. (deposition date: 2006-01-17, release date: 2006-03-07, Last modification date: 2011-07-13)

• Primary citation: McGrath, M.E.,Sprengeler, P.A.,Hirschbein, B.,Somoza, J.R.,Lehoux, I.,Janc, J.W.,Gjerstad, E.,Graupe, M.,Estiarte, A.,Venkataramani, C.,Liu, Y.,Yee, R.,Ho, J.D.,Green, M.J.,Lee, C.-S.,Liu, L.,Tai, V.,Spencer, J.,Sperandio, D.,Katz, B.A.; Structure-guided design of Peptide-based tryptase inhibitors.; Biochemistry, 45:5964-5973, 2006; PubMed: 16681368; DOI: 10.1021/bi060173m

Experimental method

X-RAY DIFFRACTION (2 Å)