1O5E

Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)

Summary for 1O5E

• Entry DOI: 10.2210/pdb1o5e/pdb
• Related: 1p57
• Descriptor: Serine protease hepsin, 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE, ... (4 entities in total)
• Functional Keywords: srcr, scavenger receptor cysteine-rich domain, serine protease ala190 upa, s1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor viia, serine protease, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type II membrane protein: P05981 P05981
• Total number of polymer chains: 2
• Total formula weight: 40458.24

Authors

Katz, B.A.,Luong, C.,Ho, J.D.,Somoza, J.R.,Gjerstad, E.,Tang, J.,Williams, S.R.,Verner, E.,Mackman, R.L.,Young, W.B.,Sprengeler, P.A.,Chan, H.,Mortara, K.,Janc, J.W.,McGrath, M.E. (deposition date: 2003-09-09, release date: 2004-09-21, Last modification date: 2023-12-27)

• Primary citation: Katz, B.A.,Luong, C.,Ho, J.D.,Somoza, J.R.,Gjerstad, E.,Tang, J.,Williams, S.R.,Verner, E.,Mackman, R.L.,Young, W.B.,Sprengeler, P.A.,Chan, H.,Mortara, K.,Janc, J.W.,McGrath, M.E.; Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).; J.Mol.Biol., 344:527-547, 2004; PubMed: 15522303; DOI: 10.1016/j.jmb.2004.09.032

Experimental method

X-RAY DIFFRACTION (1.75 Å)