2FS8

Human beta-tryptase II with inhibitor CRA-29382

Summary for 2FS8

• Entry DOI: 10.2210/pdb2fs8/pdb
• Related: 2FS9
• Descriptor: Tryptase beta-2, ALLYL {(1S)-1-[(5-{4-[(2,3-DIHYDRO-1H-INDEN-2-YLAMINO)CARBONYL]BENZYL}-1,2,4-OXADIAZOL-3-YL)CARBONYL]-3-PYRROLIDIN-3-YLPROPYL}CARBAMATE (3 entities in total)
• Functional Keywords: serine protease, proteinase, 29382, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P20231
• Total number of polymer chains: 4
• Total formula weight: 112196.26

Authors

Somoza, J.R. (deposition date: 2006-01-21, release date: 2006-03-21, Last modification date: 2017-10-18)

• Primary citation: McGrath, M.E.,Sprengeler, P.A.,Hirschbein, B.,Somoza, J.R.,Lehoux, I.,Janc, J.W.,Gjerstad, E.,Graupe, M.,Estiarte, A.,Venkataramani, C.,Liu, Y.,Yee, R.,Ho, J.D.,Green, M.J.,Lee, C.-S.,Liu, L.,Tai, V.,Spencer, J.,Sperandio, D.,Katz, B.A.; Structure-guided design of Peptide-based tryptase inhibitors.; Biochemistry, 45:5964-5973, 2006; PubMed: 16681368; DOI: 10.1021/bi060173m

Experimental method

X-RAY DIFFRACTION (2.5 Å)