1O5G

Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)

Summary for 1O5G

• Entry DOI: 10.2210/pdb1o5g/pdb
• Related: 1C5N
• Descriptor: Prothrombin, Hirudin IIIB', SODIUM ION, ... (7 entities in total)
• Functional Keywords: ala190 upa, s1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor viia, blood clotting, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28511
• Total number of polymer chains: 3
• Total formula weight: 35813.78

Authors

Katz, B.A.,Luong, C.,Ho, J.D.,Somoza, J.R.,Gjerstad, E.,Tang, J.,Williams, S.R.,Verner, E.,Mackman, R.L.,Young, W.B.,Sprengeler, P.A.,Chan, H.,Mortara, K.,Janc, J.W.,McGrath, M.E. (deposition date: 2003-09-09, release date: 2004-09-21, Last modification date: 2023-11-15)

• Primary citation: Katz, B.A.,Luong, C.,Ho, J.D.,Somoza, J.R.,Gjerstad, E.,Tang, J.,Williams, S.R.,Verner, E.,Mackman, R.L.,Young, W.B.,Sprengeler, P.A.,Chan, H.,Mortara, K.,Janc, J.W.,McGrath, M.E.; Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).; J.Mol.Biol., 344:527-547, 2004; PubMed: 15522303; DOI: 10.1016/j.jmb.2004.09.032

Experimental method

X-RAY DIFFRACTION (1.75 Å)