Author results

1B06
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SUPEROXIDE DISMUTASE FROM SULFOLOBUS ACIDOCALDARIUS
分子名称:PROTEIN (SUPEROXIDE DISMUTASE), FE (III) ION
著者Knapp, S., Kardinahl, S., Niklas, H., Tibbelin, G., Schafer, G., Ladenstein, R.
登録日1998-11-16
公開日1999-11-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Refined crystal structure of a superoxide dismutase from the hyperthermophilic archaeon Sulfolobus acidocaldarius at 2.2 A resolution.
J.Mol.Biol., 285, 1999
1B26
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GLUTAMATE DEHYDROGENASE
分子名称:GLUTAMATE DEHYDROGENASE
著者Knapp, S., Devos, W.M., Rice, D., Ladenstein, R.
登録日1998-12-04
公開日1999-12-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of glutamate dehydrogenase from the hyperthermophilic eubacterium Thermotoga maritima at 3.0 A resolution.
J.Mol.Biol., 267, 1997
1XWS
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 KINASE DOMAIN
分子名称:Proto-oncogene serine/threonine-protein kinase Pim-1, SULFATE ION, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
著者Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
登録日2004-11-02
公開日2004-11-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of human PIM1 kinase domain
To be Published
2BIK
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HUMAN PIM1 PHOSPHORYLATED ON SER261
分子名称:PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, CHLORIDE ION
著者Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
登録日2005-01-22
公開日2005-02-07
最終更新日2019-10-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Human Pim1 Phosphorylated on Ser261
To be Published
2BIL
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THE HUMAN PROTEIN KINASE PIM1 IN COMPLEX WITH ITS CONSENSUS PEPTIDE PIMTIDE
分子名称:CONSENSUS PIM1 PEPTIDE PIMTIDE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
著者Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
登録日2005-01-22
公開日2005-02-07
最終更新日2019-10-23
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献The Human Protein Kinase Pim1 in Complex with its Consensus Peptide Pimtide
To be Published
1B3B
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THERMOTOGA MARITIMA GLUTAMATE DEHYDROGENASE MUTANT N97D, G376K
分子名称:PROTEIN (GLUTAMATE DEHYDROGENASE)
著者Knapp, S., Lebbink, J.H.G., Van Der Oost, J., Devos, W.M., Rice, D., Ladenstein, R.
登録日1998-12-07
公開日1999-12-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. I. Introduction of a six-residue ion-pair network in the hinge region.
J.Mol.Biol., 280, 1998
2TMG
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THERMOTOGA MARITIMA GLUTAMATE DEHYDROGENASE MUTANT S128R, T158E, N117R, S160E
分子名称:PROTEIN (GLUTAMATE DEHYDROGENASE)
著者Knapp, S., Lebbink, J.H.G., van der Oost, J., de Vos, W.M., Rice, D., Ladenstein, R.
登録日1998-12-04
公開日1999-12-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. II: construction of a 16-residue ion-pair network at the subunit interface.
J.Mol.Biol., 289, 1999
6QXK
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HUMAN PIM1 BOUND TO OX0999
分子名称:Serine/threonine-protein kinase pim-1, Pimtide, 2-[(1-methylpiperidin-4-yl)methylamino]-5-[[2-[4-(trifluoromethyloxy)phenyl]-1,3-thiazol-4-yl]methyl]-1,3-thiazol-4-one
著者Alexander, L.T., Elkins, J.M., Russell, A., Bountra, C., Edwards, A.M., Knapp, S.
登録日2019-03-07
公開日2019-04-24
最終更新日2019-07-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献PIM1 bound to OX0999
To Be Published
4C57
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STRUCTURE OF GAK KINASE IN COMPLEX WITH A NANOBODY
分子名称:Cyclin-G-associated kinase, NANOBODY, SULFATE ION, ...
著者Chaikuad, A., Keates, T., Krojer, T., Allerston, C.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S.
登録日2013-09-10
公開日2013-10-09
最終更新日2019-07-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of Cyclin G-Associated Kinase (Gak) Trapped in Different Conformations Using Nanobodies.
Biochem.J., 459, 2014
4C58
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STRUCTURE OF GAK KINASE IN COMPLEX WITH NANOBODY (NBGAK_4)
分子名称:Cyclin-G-associated kinase, nanobody, 1,2-ETHANEDIOL, ...
著者Chaikuad, A., Keates, T., Allerston, C.K., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S.
登録日2013-09-10
公開日2013-10-09
最終更新日2019-02-06
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.
Biochem. J., 459, 2014
4C59
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STRUCTURE OF GAK KINASE IN COMPLEX WITH NANOBODY (NBGAK_4)
分子名称:Cyclin-G-associated kinase, NANOBODY, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
著者Chaikuad, A., Keates, T., Allerston, C.K., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S.
登録日2013-09-10
公開日2013-10-09
最終更新日2019-07-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.
Biochem. J., 459, 2014
1BBX
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NON-SPECIFIC PROTEIN-DNA INTERACTIONS IN THE SSO7D-DNA COMPLEX, NMR, 1 STRUCTURE
分子名称:DNA (5'-D(*CP*TP*AP*GP*CP*GP*CP*GP*CP*TP*AP*G)-3'), DNA-BINDING PROTEIN 7D
著者Agback, P., Baumann, H., Knapp, S., Ladenstein, R., Hard, T.
登録日1998-04-24
公開日1998-10-14
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Architecture of Nonspecific Protein-DNA Interactions in the Sso7D-DNA Complex
Nat.Struct.Biol., 5, 1998
2YAK
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STRUCTURE OF DEATH-ASSOCIATED PROTEIN KINASE 1 (DAPK1) IN COMPLEX WITH A RUTHENIUM OCTASPORINE LIGAND (OSV)
分子名称:DEATH-ASSOCIATED PROTEIN KINASE 1, RUTHENIUM OCTASPORINE 4
著者Feng, L., Geisselbrecht, Y., Blanck, S., Wilbuer, A., Atilla-Gokcumen, G.E., Filippakopoulos, P., Kraeling, K., Celik, M.A., Harms, K., Maksimoska, J., Marmorstein, R., Frenking, G., Knapp, S., Essen, L.-O., Meggers, E.
登録日2011-02-23
公開日2011-04-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors.
J.Am.Chem.Soc., 133, 2011
1JAK
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STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE IN COMPLEX WITH (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINIUM CHLORIDE (IFG)
分子名称:Beta-N-acetylhexosaminidase, SULFATE ION, CHLORIDE ION, ...
著者Mark, B.L., Vocadlo, D.J., Zhao, D., Knapp, S., Withers, S.G., James, M.N.
登録日2001-05-30
公開日2001-11-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor.
J.Biol.Chem., 276, 2001
1SSO
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SOLUTION STRUCTURE AND DNA-BINDING PROPERTIES OF A THERMOSTABLE PROTEIN FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS
分子名称:SSO7D
著者Baumann, H., Knapp, S., Lundback, T., Ladenstein, R., Hard, T.
登録日1995-03-31
公開日1995-05-08
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus.
Nat.Struct.Biol., 1, 1994
3PUP
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STRUCTURE OF GLYCOGEN SYNTHASE KINASE 3 BETA (GSK3B) IN COMPLEX WITH A RUTHENIUM OCTASPORINE LIGAND (OS1)
分子名称:Glycogen synthase kinase-3 beta, Ruthenium octasporine
著者Filippakopoulos, P., Kraling, K., Essen, L.O., Meggers, E., Knapp, S.
登録日2010-12-06
公開日2010-12-22
最終更新日2012-02-29
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors.
J.Am.Chem.Soc., 133, 2011
1Z57
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CRYSTAL STRUCTURE OF HUMAN CLK1 IN COMPLEX WITH 10Z-HYMENIALDISINE
分子名称:Dual specificity protein kinase CLK1, DEBROMOHYMENIALDISINE
著者Debreczeni, J., Das, S., Knapp, S., Bullock, A., Guo, K., Amos, A., Fedorov, O., Edwards, A., Sundstrom, M., von Delft, F., Niesen, F.H., Ball, L., Sobott, F., Arrowsmith, C., Structural Genomics Consortium (SGC)
登録日2005-03-17
公開日2005-04-12
最終更新日2012-08-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
2EU9
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CRYSTAL STRUCTURE OF CLK3
分子名称:Dual specificity protein kinase CLK3, 1,2-ETHANEDIOL
著者Papagrigoriou, E., Rellos, P., Das, S., Ugochukwu, E., Turnbull, A., von Delft, F., Bunkoczi, G., Sobott, F., Bullock, A., Fedorov, O., Gileadi, C., Savitsky, P., Edwards, A., Aerrowsmith, C., Weigelt, J., Sundstrom, M., Knapp, S.
登録日2005-10-28
公開日2005-11-08
最終更新日2012-08-29
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
2IVX
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CRYSTAL STRUCTURE OF HUMAN CYCLIN T2 AT 1.8 A RESOLUTION
分子名称:CYCLIN-T2, 1,2-ETHANEDIOL
著者Debreczeni, J.E., Bullock, A.N., Fedorov, O., Savitsky, P., Berridge, G., Das, S., Pike, A.C.W., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Gorrec, F., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
登録日2006-06-21
公開日2006-07-19
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
EMBO J., 27, 2008
2JAV
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HUMAN KINASE WITH PYRROLE-INDOLINONE LIGAND
分子名称:SERINE/THREONINE-PROTEIN KINASE NEK2, 5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
著者Pike, A.C.W., Rellos, P., Das, S., Fedorov, O., Papagrigoriou, E., Debreczeni, J.E., Turnbull, A.P., Gorrec, F., Bray, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A., Weigelt, J., von Delft, F., Knapp, S.
登録日2006-11-30
公開日2006-12-04
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure and Regulation of the Human Nek2 Centrosomal Kinase
J.Biol.Chem., 282, 2007
2QEP
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CRYSTAL STRUCTURE OF THE D1 DOMAIN OF PTPRN2 (IA2BETA)
分子名称:Receptor-type tyrosine-protein phosphatase N2, CHLORIDE ION
著者Ugochukwu, E., Barr, A., Alfano, I., Berridge, G., Burgess-Brown, N., Das, S., Fedorov, O., King, O., Niesen, F., Watt, S., Savitsky, P., Salah, E., Pike, A.C.W., Bunkoczi, G., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
登録日2007-06-26
公開日2007-07-24
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
3D7C
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN GCN5, THE GENERAL CONTROL OF AMINO-ACID SYNTHESIS PROTEIN 5-LIKE 2
分子名称:General control of amino acid synthesis protein 5-like 2
著者Filippakopoulos, P., Eswaran, J., Picaud, S., Fedorov, O., Murray, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2008-05-21
公開日2008-07-15
最終更新日2012-04-11
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3DAI
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2
分子名称:ATPase family AAA domain-containing protein 2, SULFATE ION, CHLORIDE ION
著者Filippakopoulos, P., Keates, T., Picaud, S., Fedorov, O., Roos, A.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2008-05-29
公開日2008-09-09
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3DWY
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP
分子名称:CREB-binding protein, 1,2-ETHANEDIOL
著者Filippakopoulos, P., Picaud, S., Fedorov, O., Karim, R., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wickstroem, M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2008-07-23
公開日2008-08-05
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3GG3
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN PCAF
分子名称:Histone acetyltransferase PCAF, CHLORIDE ION
著者Filippakopoulos, P., Keates, T., Picaud, S., Rehana, K., Fedorov, O., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2009-02-27
公開日2009-03-17
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012