Author results

2AJP
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CRYSTAL STRUCTURE OF A HUMAN PYRIDOXAL KINASE
Descriptor:Pyridoxal kinase, MAGNESIUM ION, UNKNOWN ATOM OR ION, ...
Authors:Ismail, S., Dimov, S., Atanassova, A., Tempel, W., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2005-08-02
Release date:2005-08-09
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a human pyridoxal kinase
To be Published
2AL7
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STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 10C
Descriptor:ADP-ribosylation factor-like 10C, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Ismail, S., Dimov, S., Atanassova, A., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2005-08-04
Release date:2005-08-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:GTP-like conformation of GDP-bound ARL10C GTPase
To be Published
2B0O
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CRYSTAL STRUCTURE OF UPLC1 GAP DOMAIN
Descriptor:UPLC1, ZINC ION
Authors:Ismail, S., Shen, L., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2005-09-14
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural analysis of GAP and ankyrin domains of UPLC1
To be Published
5E80
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THE CRYSTAL STRUCTURE OF PDED IN COMPLEX WITH INHIBITOR-2A
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, N-(3-chloro-2-methylphenyl)-4-(3,4-dimethyl-7-oxo-2-phenyl-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide
Authors:Ismail, S., Fansa, E.K., Murarka, S., Wittinghofer, A.
Deposit date:2015-10-13
Release date:2016-05-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of pyrazolopyridazinones as PDE delta inhibitors.
Nat Commun, 7, 2016
1ZYR
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STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC STREPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase subunit beta' chain, ...
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark, A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-10
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
2CW0
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME AT 3.3 ANGSTROMS RESOLUTION
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark Jr., A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-15
Release date:2005-09-20
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
4JV6
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THE CRYSTAL STRUCTURE OF PDE6D IN COMPLEX TO INHIBITOR-1
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, 1-benzyl-2-phenyl-1H-benzimidazole
Authors:Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JV8
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THE CRYSTAL STRUCTURE OF PDE6D IN COMPLEX WITH RAC-S1
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (6R)-6-(pyridin-2-yl)-5,6-dihydrobenzimidazo[1,2-c]quinazoline
Authors:Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JVB
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CRYSTAL STRUCTURE OF PDE6D IN COMPLEX WITH THE INHIBITOR RAC-2
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, 1-benzyl-2-(4-{[(2R)-2-(2-phenyl-1H-benzimidazol-1-yl)pent-4-en-1-yl]oxy}phenyl)-1H-benzimidazole
Authors:Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JVF
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THE CRYSTAL STRUCTURE OF PDE6D IN COMPLEX WITH THE INHIBITOR (S)-5
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(piperidin-4-yl)ethyl 1-(1-benzyl-1H-benzimidazol-2-yl)piperidine-4-carboxylate
Authors:Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
Deposit date:2013-03-25
Release date:2013-05-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
2AX4
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULPHATE SYNTHETASE 2
Descriptor:Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2, ADENOSINE-5'-DIPHOSPHATE
Authors:Rabeh, W.M., Nedyalkova, L., Ismail, S., Park, H., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Structural Genomics Consortium (SGC)
Deposit date:2005-09-02
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the kinase domain of PAPSS 2
To be Published
2EW1
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CRYSTAL STRUCTURE OF RAB30 IN COMPLEX WITH A GTP ANALOGUE
Descriptor:Ras-related protein Rab-30, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Wang, J., Shen, Y., Ismail, S., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2005-11-01
Release date:2005-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of RAB30 in complex with a GTP analogue
To be Published
2F7S
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THE CRYSTAL STRUCTURE OF HUMAN RAB27B BOUND TO GDP
Descriptor:Ras-related protein Rab-27B, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Wang, J., Ismail, S., Shen, Y., Tempel, W., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2005-12-01
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of human Rab27b
To be Published
2FG5
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CRYSTAL STRUCTURE OF HUMAN RAB31 IN COMPLEX WITH A GTP ANALOGUE
Descriptor:Ras-related protein Rab-31, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Tempel, W., Wang, J., Ismail, S., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2005-12-21
Release date:2006-01-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Crystal structure of human RAB31 in complex with a GTP analogue
To be Published
4JHN
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THE CRYSTAL STRUCTURE OF THE RPGR RCC1-LIKE DOMAIN
Descriptor:X-linked retinitis pigmentosa GTPase regulator
Authors:Waetzlich, D., Vetter, I., Wittinghofer, A., Ismail, S.
Deposit date:2013-03-05
Release date:2013-04-17
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The interplay between RPGR, PDE-delta and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Embo Rep., 14, 2013
4JHP
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THE CRYSTAL STRUCTURE OF THE RPGR RCC1-LIKE DOMAIN IN COMPLEX WITH PDE6D
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, X-linked retinitis pigmentosa GTPase regulator
Authors:Waetzlich, D., Vetter, I., Wittinghofer, A., Ismail, S.
Deposit date:2013-03-05
Release date:2013-04-17
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The interplay between RPGR, PDE-delta and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Embo Rep., 14, 2013
6H6A
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CRYSTAL STRUCTURE OF UNC119 IN COMPLEX WITH LCK PEPTIDE
Descriptor:Protein unc-119 homolog A, GLY-CYS-GLY-CYS-SER-SER, GLYCEROL, ...
Authors:Yelland, T., ElMaghloob, Y., McIlwraith, M., Stephen, L., Ismail, S.
Deposit date:2018-07-26
Release date:2018-09-26
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.
Dev.Cell, 47, 2018
7AJK
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CRYSTAL STRUCTURE OF CRYI-B RAC1 COMPLEX
Descriptor:Ras-related C3 botulinum toxin substrate 1, CYFIP-related Rac1 interactor B, MAGNESIUM ION, ...
Authors:Yelland, T., Anh, L., Insall, R., Machesky, L., Ismail, S.
Deposit date:2020-09-29
Release date:2020-11-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of the CRYI-B Rac1 complex
To Be Published
7AJL
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CYRSTAL STRUCTURE OF CYRI-B/FAM49B
Descriptor:CYFIP-related Rac1 interactor B
Authors:Yelland, T., Anh, H., Insall, R., Machesky, L., Ismail, S.
Deposit date:2020-09-29
Release date:2020-11-18
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Cyrstal structure of CYRI-B/Fam49B
To Be Published
4GOJ
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THE CRYSTAL STRUCTURE OF FULL LENGTH ARL3GPPNHP IN COMPLEX WITH UNC119A
Descriptor:ADP-ribosylation factor-like protein 3, Protein unc-119 homolog A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Ismail, S., Xiang-Chen, Y., Miertzschke, M., Vetter, I., Koerner, C., Wittinghofer, A.
Deposit date:2012-08-20
Release date:2012-09-19
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.
Embo J., 31, 2012
4GOK
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THE CRYSTAL STRUCTURE OF ARL2GPPNHP IN COMPLEX WITH UNC119A
Descriptor:ADP-ribosylation factor-like protein 2, Protein unc-119 homolog A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Ismail, S., Xiang-Chen, Y., Miertzschke, M., Vetter, I., Koerner, C., Wittinghofer, A.
Deposit date:2012-08-20
Release date:2012-09-19
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.
Embo J., 31, 2012
5E8F
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STRUCTURE OF FULLY MODIFIED GERANYLGERANYLATED PDE6C PEPTIDE IN COMPLEX WITH PDE6D
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha', GERAN-8-YL GERAN
Authors:Fansa, E.K., O'Reilly, N.J., Ismail, S.A., Wittinghofer, A.
Deposit date:2015-10-14
Release date:2015-11-18
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The N- and C-terminal ends of RPGR can bind to PDE6 delta.
Embo Rep., 16, 2015
5M3Q
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CRYSTAL STRUCTURE OF TIF6 FROM CHAETOMIUM THERMOPHILUM
Descriptor:Eukaryotic translation initiation factor 6, SULFATE ION, GLYCEROL
Authors:Ahmed, Y.L., Calvino, F.R., Sinning, I.
Deposit date:2016-10-17
Release date:2016-11-30
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Interaction network of the ribosome assembly machinery from a eukaryotic thermophile.
Protein Sci., 26, 2017
5M43
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CRYSTAL STRUCTURE OF YVH1 PHOSPHATASE DOMAIN FROM CHAETOMIUM THERMOPHILUM
Descriptor:Putative uncharacterized protein, NITRATE ION, GLYCEROL
Authors:Ahmed, Y.L., Sinning, I.
Deposit date:2016-10-18
Release date:2016-11-30
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (1.646 Å)
Cite:Interaction network of the ribosome assembly machinery from a eukaryotic thermophile.
Protein Sci., 26, 2017
3DXJ
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC MYXOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha; CHAIN A, B, K, ...
Authors:Das, K., Arnold, E.
Deposit date:2008-07-24
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The RNA polymerase "switch region" is a target for inhibitors.
Cell(Cambridge,Mass.), 135, 2008
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171916
PDB entries from 2020-12-02