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4JVF

The Crystal structure of PDE6D in complex with the inhibitor (s)-5

Summary for 4JVF
Entry DOI10.2210/pdb4jvf/pdb
Related4JV6 4JV8 4JVB
DescriptorRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(piperidin-4-yl)ethyl 1-(1-benzyl-1H-benzimidazol-2-yl)piperidine-4-carboxylate (3 entities in total)
Functional Keywordsimmunoglobulin-like beta-sandwich, gdi-like solubilizing factor, prenyl binding, protein binding-inhibitor complex, protein binding/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytosol : O43924
Total number of polymer chains1
Total formula weight18223.92
Authors
Gunther, Z.,Papke, B.,Ismail, S.,Vartak, N.,Chandra, A.,Hoffmann, M.,Hahn, S.,Triola, G.,Wittinghofer, A.,Bastiaens, P.,Waldmann, H. (deposition date: 2013-03-25, release date: 2013-05-22, Last modification date: 2023-09-20)
Primary citationZimmermann, G.,Papke, B.,Ismail, S.,Vartak, N.,Chandra, A.,Hoffmann, M.,Hahn, S.A.,Triola, G.,Wittinghofer, A.,Bastiaens, P.I.,Waldmann, H.
Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497:638-642, 2013
Cited by
PubMed: 23698361
DOI: 10.1038/nature12205
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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