5E80

The crystal structure of PDEd in complex with inhibitor-2a

Summary for 5E80

• Entry DOI: 10.2210/pdb5e80/pdb
• Descriptor: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, N-(3-chloro-2-methylphenyl)-4-(3,4-dimethyl-7-oxo-2-phenyl-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide (3 entities in total)
• Functional Keywords: prenyl binding protein /inhibitor, immunoglobulin-like beta-sandwich, gdi-like solubilizing factor, lipid binding protein
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytosol : O43924
• Total number of polymer chains: 2
• Total formula weight: 35403.38

Authors

Ismail, S.,Fansa, E.K.,Murarka, S.,Wittinghofer, A. (deposition date: 2015-10-13, release date: 2016-05-04, Last modification date: 2024-01-10)

• Primary citation: Papke, B.,Murarka, S.,Vogel, H.A.,Martin-Gago, P.,Kovacevic, M.,Truxius, D.C.,Fansa, E.K.,Ismail, S.,Zimmermann, G.,Heinelt, K.,Schultz-Fademrecht, C.,Al Saabi, A.,Baumann, M.,Nussbaumer, P.,Wittinghofer, A.,Waldmann, H.,Bastiaens, P.I.; Identification of pyrazolopyridazinones as PDE delta inhibitors.; Nat Commun, 7:11360-11360, 2016; PubMed: 27094677; DOI: 10.1038/ncomms11360

Experimental method

X-RAY DIFFRACTION (2.6 Å)