5E80
The crystal structure of PDEd in complex with inhibitor-2a
Summary for 5E80
Entry DOI | 10.2210/pdb5e80/pdb |
Descriptor | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, N-(3-chloro-2-methylphenyl)-4-(3,4-dimethyl-7-oxo-2-phenyl-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide (3 entities in total) |
Functional Keywords | prenyl binding protein /inhibitor, immunoglobulin-like beta-sandwich, gdi-like solubilizing factor, lipid binding protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : O43924 |
Total number of polymer chains | 2 |
Total formula weight | 35403.38 |
Authors | Ismail, S.,Fansa, E.K.,Murarka, S.,Wittinghofer, A. (deposition date: 2015-10-13, release date: 2016-05-04, Last modification date: 2024-01-10) |
Primary citation | Papke, B.,Murarka, S.,Vogel, H.A.,Martin-Gago, P.,Kovacevic, M.,Truxius, D.C.,Fansa, E.K.,Ismail, S.,Zimmermann, G.,Heinelt, K.,Schultz-Fademrecht, C.,Al Saabi, A.,Baumann, M.,Nussbaumer, P.,Wittinghofer, A.,Waldmann, H.,Bastiaens, P.I. Identification of pyrazolopyridazinones as PDE delta inhibitors. Nat Commun, 7:11360-11360, 2016 Cited by PubMed: 27094677DOI: 10.1038/ncomms11360 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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