7Q9Q

Crystal structure of PDE6D Geranylgeranylated cystein complex

This is a non-PDB format compatible entry.

Summary for 7Q9Q

• Entry DOI: 10.2210/pdb7q9q/pdb
• Descriptor: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, O-METHYLCYSTEINE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: complex, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 18326.09

Authors

Yelland, T.,Ismail, S. (deposition date: 2021-11-14, release date: 2022-01-19, Last modification date: 2024-01-31)

• Primary citation: Yelland, T.,Garcia, E.,Parry, C.,Kowalczyk, D.,Wojnowska, M.,Gohlke, A.,Zalar, M.,Cameron, K.,Goodwin, G.,Yu, Q.,Zhu, P.C.,ElMaghloob, Y.,Pugliese, A.,Archibald, L.,Jamieson, A.,Chen, Y.X.,McArthur, D.,Bower, J.,Ismail, S.; Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.; J.Med.Chem., 65:1898-1914, 2022; PubMed: 35104933; DOI: 10.1021/acs.jmedchem.1c01265

Experimental method

X-RAY DIFFRACTION (1.45 Å)