Author results

5XZR
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THE ATOMIC STRUCTURE OF SHP2 E76A MUTANT IN COMPLEX WITH ALLOSTERIC INHIBITOR 9B
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, 4-(3-phenylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3-thiazol-2-amine
Authors:Li, D., Xie, J., Zhu, J., Liu, C.
Deposit date:2017-07-13
Release date:2017-12-13
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
J. Med. Chem., 60, 2017
5NBG
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STRUCTURE OF THE CYTOPLASMIC DOMAIN I OF OUTF IN THE D. DADANTII TYPE II SECRETION SYSTEM
Descriptor:General secretion pathway protein F
Authors:Zhang, H., Gu, S.
Deposit date:2017-03-01
Release date:2018-03-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of the first cytoplasmic domain of OutF and assembly of the inner-membrane platform proteins of the D. dadantii type II secretion system
To Be Published
5M7F
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HUMAN PORPHOBILINOGEN DEAMINASE IN COMPLEX WITH DPM COFACTOR
Descriptor:Porphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, SULFATE ION
Authors:Pluta, P., Millet, O., Roversi, P., Rojas, A.L., Gu, S.
Deposit date:2016-10-27
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Human Porphobilinogen deaminase in complex with DPM cofactor
To Be Published
5M6R
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HUMAN PORPHOBILINOGEN DEAMINASE IN COMPLEX WITH REACTION INTERMEDIATE
Descriptor:Porphobilinogen deaminase, 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, PHOSPHATE ION, ...
Authors:Pluta, P., Millet, O., Roversi, P., Rojas, A.L., Gu, S.
Deposit date:2016-10-25
Release date:2017-11-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Human Porphobilinogen deaminase in complex with reaction intermediate
To Be Published
5GMQ
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STRUCTURE OF MERS-COV RBD IN COMPLEX WITH A FULLY HUMAN ANTIBODY MCA1
Descriptor:S protein, MCA1 heavy chain, MCA1 light chain, ...
Authors:Chen, C., Wang, J.M., Zou, T.T., Gao, X.P., Cui, S., Jin, Q.
Deposit date:2016-07-15
Release date:2017-05-31
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset.
J. Infect. Dis., 215, 2017
5HM7
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THE INTRACELLULAR DOMAIN OF BUTYROPHILIN 3A1 PROTEIN
Descriptor:Butyrophilin subfamily 3 member A1, GLYCEROL, BETA-MERCAPTOETHANOL, ...
Authors:Adams, E.J., Gu, S.
Deposit date:2016-01-15
Release date:2017-07-26
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on V gamma 9V delta 2 T cell activation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5D6J
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CRYSTAL STRUCTURE OF A MYCOBACTERIAL PROTEIN
Descriptor:Acyl-CoA synthase, Ubiquitin-like protein SMT3, MAGNESIUM ION, ...
Authors:Li, W.J., Bi, L.J.
Deposit date:2015-08-12
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria.
Sci Rep, 5, 2015
5D6N
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CRYSTAL STRUCTURE OF A MYCOBACTERIAL PROTEIN
Descriptor:Acyl-CoA synthase
Authors:Li, W.J., Bi, L.J.
Deposit date:2015-08-12
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria.
Sci Rep, 5, 2015
5C4N
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COBK PRECORRIN-6A REDUCTASE
Descriptor:Precorrin-6A reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Gu, S., Pickersgill, R.W.
Deposit date:2015-06-18
Release date:2015-12-09
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Crystal structure of CobK
To Be Published
5C4R
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COBK PRECORRIN-6A REDUCTASE
Descriptor:Precorrin-6A reductase
Authors:Gu, S., Pickersgill, R.W.
Deposit date:2015-06-18
Release date:2016-11-16
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Crystal structure of CobK reveals strand-swapping between Rossmann-fold domains and molecular basis of the reduced precorrin product trap.
Sci Rep, 5, 2015
4X7G
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COBK PRECORRIN-6A REDUCTASE
Descriptor:Precorrin-6A reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[(1R,2S,3S,7S,11S,16S,17R,18R,19R)-2,7,12,18-tetrakis(2-hydroxy-2-oxoethyl)-3,13-bis(3-hydroxy-3-oxopropyl)-1,2,5,7,11,17-hexamethyl-17-(3-oxidanyl-3-oxidanylidene-prop-1-enyl)-3,6,8,10,15,16,18,19,21,24-decahydrocorrin-8-yl]propanoic acid
Authors:Gu, S., Deery, E., Warren, M.J., Pickersgill, R.W.
Deposit date:2014-12-09
Release date:2016-01-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Crystal structure of CobK reveals strand-swapping between Rossmann-fold domains and molecular basis of the reduced precorrin product trap.
Sci Rep, 5, 2015
4QD2
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MOLECULAR BASIS FOR DISRUPTION OF E-CADHERIN ADHESION BY BOTULINUM NEUROTOXIN A COMPLEX
Descriptor:Hemagglutinin component HA33, Hemagglutinin component HA17, Hemagglutinin component HA70, ...
Authors:Lee, K., Zhong, X., Gu, S., Kruel, A., Dorner, M.B., Perry, K., Rummel, A., Dong, M., Jin, R.
Deposit date:2014-05-13
Release date:2014-06-25
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.
Science, 344, 2014
4LO0
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APO HA17-HA33
Descriptor:HA-33, HA-17
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.055 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO1
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HA17-HA33-GAL
Descriptor:HA-33, HA-17, BETA-D-GALACTOSE
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.254 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO2
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HA17-HA33-LAC
Descriptor:HA-33, HA-17, BETA-D-GALACTOSE, ...
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.254 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO3
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HA17-HA33-LACNAC
Descriptor:HA-33, HA-17, BETA-D-GALACTOSE, ...
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.249 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO4
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APO HA-70
Descriptor:HA-70, CHLORIDE ION
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.871 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO5
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HA70-ALPHA2,3-SIALC
Descriptor:HA-70, O-SIALIC ACID, BETA-D-GALACTOSE, ...
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO6
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HA70-ALPHA2,6-SIALC
Descriptor:HA-70, O-SIALIC ACID, BETA-D-GALACTOSE, ...
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO7
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HA70(D3)-HA17-HA33
Descriptor:HA-70, HA-33, HA-17
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.73 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO8
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HA70(D3)-HA17
Descriptor:HA-70, HA-17
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4K0U
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PILOTIN/SECRETIN PEPTIDE COMPLEX
Descriptor:Lipoprotein OutS, Type II secretion system protein D
Authors:Rehman, S., Pickersgill, R.W.
Deposit date:2013-04-04
Release date:2013-05-15
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Anatomy of secretin binding to the Dickeya dadantii type II secretion system pilotin.
Acta Crystallogr.,Sect.D, 69, 2013
4HCB
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THE METAL-FREE FORM OF CRYSTAL STRUCTURE OF E.COLI EXOI-SSDNA COMPLEX
Descriptor:Exodeoxyribonuclease I, DNA (5'-D(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), GLYCEROL, ...
Authors:Qiu, R., Wei, J., Lou, T., Liu, M., Ji, C., Gong, W.
Deposit date:2012-09-29
Release date:2013-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structures of Escherichia coli exonuclease I in complex with the single strand DNA
To be published
4HCC
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THE ZINC ION BOUND FORM OF CRYSTAL STRUCTURE OF E.COLI EXOI-SSDNA COMPLEX
Descriptor:Exodeoxyribonuclease I, DNA (5'-D(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), SULFATE ION, ...
Authors:Qiu, R., Wei, J., Lou, T., Liu, M., Ji, C., Gong, W.
Deposit date:2012-09-29
Release date:2013-10-09
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:The structures of Escherichia coli exonuclease I in complex with the single strand DNA
To be published
4H86
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CRYSTAL STRUCTURE OF AHP1 FROM SACCHAROMYCES CEREVISIAE IN REDUCED FORM
Descriptor:Peroxiredoxin type-2
Authors:Liu, M., Wang, F., Qiu, R., Wu, T., Gu, S., Tang, R., Ji, C.
Deposit date:2012-09-21
Release date:2012-10-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Crystal structure of Ahp1 from Saccharomyces cerevisiae in reduced form
To be Published
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