Author results

1LAT
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GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX
Descriptor:DNA (5'-D(*TP*TP*CP*CP*AP*GP*AP*AP*CP*AP*TP*GP*TP*TP*CP*TP*G P*GP*A)-3'), GLUCOCORTICOID RECEPTOR, ZINC ION
Authors:Gewirth, D.T., Sigler, P.B.
Deposit date:1995-12-18
Release date:1996-04-03
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The basis for half-site specificity explored through a non-cognate steroid receptor-DNA complex.
Nat.Struct.Biol., 2, 1995
1U0Z
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N-DOMAIN OF GRP94 LACKING THE CHARGED DOMAIN IN COMPLEX WITH RADICICOL
Descriptor:Endoplasmin, RADICICOL, TETRAETHYLENE GLYCOL, ...
Authors:Gewirth, D.T., Immormino, R.M.
Deposit date:2004-07-14
Release date:2005-07-05
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:N-Domain Of Grp94 Lacking The Charged Domain In Complex With Radicicol
TO BE PUBLISHED
6D1X
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N-DOMAIN OF GRP94, WITH THE CHARGED DOMAIN, IN COMPLEX WITH THE NOVEL LIGAND N-PROPYL CARBOXYAMIDO ADENOSINE
Descriptor:Endoplasmin, N-PROPYL CARBOXYAMIDO ADENOSINE, TETRAETHYLENE GLYCOL
Authors:Gewirth, D.T., Immormino, R.M.
Deposit date:2018-04-12
Release date:2018-05-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:N-Domain Of Grp94, with the Charged Domain, In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine
To Be Published
1TBW
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LIGAND INDUCED CONFORMATIONAL SHIFT IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION
Descriptor:Endoplasmin, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE, ...
Authors:Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC0
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LIGAND INDUCED CONFORMATIONAL SHIFTS IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION COMPLEXED WITH THE PHYSIOLOGICAL PARTNER ATP
Descriptor:Endoplasmin, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC6
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LIGAND INDUCED CONFORMATIONAL SHIFT IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION ADP-COMPLEX
Descriptor:Endoplasmin, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1KB2
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CRYSTAL STRUCTURE OF VDR DNA-BINDING DOMAIN BOUND TO MOUSE OSTEOPONTIN (SPP) RESPONSE ELEMENT
Descriptor:5'-D(*CP*AP*CP*GP*GP*TP*TP*CP*AP*CP*GP*AP*GP*GP*TP*TP*CP*A)-3', 5'-D(*TP*GP*AP*AP*CP*CP*TP*CP*GP*TP*GP*AP*AP*CP*CP*GP*TP*G)-3', Vitamin D3 Receptor, ...
Authors:Shaffer, P.L., Gewirth, D.T.
Deposit date:2001-11-05
Release date:2002-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of VDR-DNA interactions on direct repeat response elements.
EMBO J., 21, 2002
1KB4
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CRYSTAL STRUCTURE OF VDR DNA-BINDING DOMAIN BOUND TO A CANONICAL DIRECT REPEAT WITH THREE BASE PAIR SPACER (DR3) RESPONSE ELEMENT
Descriptor:5'-D(*CP*AP*CP*AP*GP*GP*TP*CP*AP*CP*GP*AP*AP*GP*GP*TP*CP*A)-3', 5'-D(*TP*GP*AP*CP*CP*TP*TP*CP*GP*TP*GP*AP*CP*CP*TP*GP*TP*G)-3', Vitamin D3 Receptor, ...
Authors:Shaffer, P.L., Gewirth, D.T.
Deposit date:2001-11-05
Release date:2002-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of VDR-DNA interactions on direct repeat response elements.
EMBO J., 21, 2002
1KB6
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CRYSTAL STRUCTURE OF VDR DNA-BINDING DOMAIN BOUND TO RAT OSTEOCALCIN (OC) RESPONSE ELEMENT
Descriptor:5'-D(*CP*AP*CP*GP*GP*GP*TP*GP*AP*AP*TP*GP*AP*GP*GP*AP*CP*A)-3', 5'-D(*TP*GP*TP*CP*CP*TP*CP*AP*TP*TP*CP*AP*CP*CP*CP*GP*TP*G)-3', Vitamin D3 Receptor, ...
Authors:Shaffer, P.L., Gewirth, D.T.
Deposit date:2001-11-05
Release date:2002-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of VDR-DNA interactions on direct repeat response elements.
EMBO J., 21, 2002
1QY8
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CRYSTAL STRUCTURE OF THE N-DOMAIN OF THE ER HSP90 CHAPERONE GRP94 IN COMPLEX WITH RADICICOL
Descriptor:Endoplasmin, RADICICOL
Authors:Soldano, K.L., Jivan, A., Nicchitta, C.V., Gewirth, D.T.
Deposit date:2003-09-09
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation
J.Biol.Chem., 278, 2003
1QYE
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CRYSTAL STRUCTURE OF THE N-DOMAIN OF THE ER HSP90 CHAPERONE GRP94 IN COMPLEX WITH 2-CHLORODIDEOXYADENOSINE
Descriptor:Endoplasmin, 2-CHLORODIDEOXYADENOSINE, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE
Authors:Soldano, K.L., Jivan, A., Nicchitta, C.V., Gewirth, D.T.
Deposit date:2003-09-10
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the N-terminal Domain of GRP94. Basis for Ligand Specificity and Regulation
J.Biol.Chem., 278, 2003
1R4I
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CRYSTAL STRUCTURE OF ANDROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO A DIRECT REPEAT RESPONSE ELEMENT
Descriptor:5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*TP*CP*AP*AP*GP*AP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*TP*CP*TP*TP*GP*AP*TP*GP*TP*TP*CP*TP*GP*G)-3', Androgen receptor, ...
Authors:Shaffer, P.L., Jivan, A., Dollins, D.E., Claessens, F., Gewirth, D.T.
Deposit date:2003-10-06
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of androgen receptor binding to selective androgen response elements.
Proc.Natl.Acad.Sci.USA, 101, 2004
1RM1
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STRUCTURE OF A YEAST TFIIA/TBP/TATA-BOX DNA COMPLEX
Descriptor:5'-D(*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*AP*TP*AP*AP*AP*AP*CP*G)-3', 5'-D(P*CP*GP*TP*TP*TP*TP*AP*TP*AP*TP*CP*GP*AP*TP*CP*GP*AP*T)-3', TATA-box binding protein, ...
Authors:Jin, X., Gewirth, D.T., Geiger, J.H.
Deposit date:2003-11-26
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:High Resolution Structure of a Yeast TFIIA/TBP/TATA-box DNA Complex
TO BE PUBLISHED
1U2O
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CRYSTAL STRUCTURE OF THE N-DOMAIN OF GRP94 LACKING THE CHARGED DOMAIN IN COMPLEX WITH NECA
Descriptor:Endoplasmin, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, TETRAETHYLENE GLYCOL, ...
Authors:Soldano, K.L., Jivan, A., Nicchitta, C.V., Gewirth, D.T.
Deposit date:2004-07-19
Release date:2004-08-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation
J.Biol.Chem., 278, 2003
1YNW
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CRYSTAL STRUCTURE OF VITAMIN D RECEPTOR AND 9-CIS RETINOIC ACID RECEPTOR DNA-BINDING DOMAINS BOUND TO A DR3 RESPONSE ELEMENT
Descriptor:5'-d(*TP*TP*AP*GP*GP*TP*CP*AP*CP*GP*AP*AP*GP*GP*TP*CP*AP*A)-3', 5'-d(*TP*TP*TP*GP*AP*CP*CP*TP*TP*CP*GP*TP*GP*AP*CP*CP*TP*A)-3', Vitamin D3 Receptor, ...
Authors:Shaffer, P.L., Gewirth, D.T.
Deposit date:2005-01-25
Release date:2005-02-15
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of RXR-VDR interactions on DR3 DNA
J.Steroid Biochem.Mol.Biol., 89-90, 2004
1YSZ
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CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH NECA
Descriptor:Endoplasmin, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, TETRAETHYLENE GLYCOL
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YT0
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CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH ADP
Descriptor:Endoplasmin, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YT1
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CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL
Descriptor:Endoplasmin, TETRAETHYLENE GLYCOL, PENTAETHYLENE GLYCOL
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YT2
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CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N APO CRYSTAL
Descriptor:Endoplasmin, TETRAETHYLENE GLYCOL
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1ZW9
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YEAST HSP82 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
Descriptor:HSP82, 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
Authors:Immormino, R.M., Gewirth, D.T., Chiosis, G.
Deposit date:2005-06-03
Release date:2006-06-13
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design
To be Published
1ZWH
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YEAST HSP82 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR RADESTER AMINE
Descriptor:ATP-dependent molecular chaperone HSP82, 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Authors:Immormino, R.M., Blagg, B.S., Gewirth, D.T.
Deposit date:2005-06-03
Release date:2006-06-13
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design
To be Published
2AQ9
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STRUCTURE OF E. COLI LPXA WITH A BOUND PEPTIDE THAT IS COMPETITIVE WITH ACYL-ACP
Descriptor:Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, peptide inhibitor, PHOSPHATE ION, ...
Authors:Williams, A.H., Immormino, R.M., Gewirth, D.T., Raetz, C.R.
Deposit date:2005-08-17
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2ESA
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GRP94 N-TERMINAL DOMAIN BOUND TO GELDANAMYCIN: EFFECTS OF MUTANTS 168-169 KS-AA
Descriptor:Endoplasmin, GELDANAMYCIN, TETRAETHYLENE GLYCOL, ...
Authors:Immormino, R.M., Metzger IV, L.E., Gewirth, D.T.
Deposit date:2005-10-25
Release date:2006-10-03
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of GRP94 with the specific mutation KS168-169AA; with bound Geldanamycin
To be Published
2EXL
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GRP94 N-TERMINAL DOMAIN BOUND TO GELDANAMYCIN
Descriptor:Endoplasmin, GELDANAMYCIN, TETRAETHYLENE GLYCOL, ...
Authors:Reardon, P.N., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-11-08
Release date:2006-10-24
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
J.Mol.Biol., 388, 2009
2FWY
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STRUCTURE OF HUMAN HSP90-ALPHA BOUND TO THE POTENT WATER SOLUBLE INHIBITOR PU-H64
Descriptor:Heat shock protein HSP 90-alpha, 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
Authors:Immormino, R.M., Gewirth, D.T.
Deposit date:2006-02-03
Release date:2006-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.
J.Med.Chem., 49, 2006
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