3O0I

Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor PU-H54

Summary for 3O0I

Entry DOI	10.2210/pdb3o0i/pdb
Related	3C11
Descriptor	HSP90AA1 protein, 8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine (3 entities in total)
Functional Keywords	hsp90 heat-shock proteins, chaperone-inhibitor complex, chaperone/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	29110.59
Authors	Seidler, P.M.,Gewirth, D.T. (deposition date: 2010-07-19, release date: 2011-10-05, Last modification date: 2024-02-21)
Primary citation	Patel, P.D.,Yan, P.,Seidler, P.M.,Patel, H.J.,Sun, W.,Yang, C.,Que, N.S.,Taldone, T.,Finotti, P.,Stephani, R.A.,Gewirth, D.T.,Chiosis, G. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat.Chem.Biol., 9:677-684, 2013 Cited by PubMed: 23995768 DOI: 10.1038/nchembio.1335 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation