6N8Y
Hsp90-beta bound to PU-11-trans
Summary for 6N8Y
Entry DOI | 10.2210/pdb6n8y/pdb |
Descriptor | Heat shock protein HSP 90-beta, 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine (3 entities in total) |
Functional Keywords | hsp90, inhibitor, cancer, cytosol, chaperone, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 27343.81 |
Authors | Huck, J.D.,Que, N.L.S.,Gewirth, D.T. (deposition date: 2018-11-30, release date: 2019-07-03, Last modification date: 2023-10-11) |
Primary citation | Huck, J.D.,Que, N.L.S.,Sharma, S.,Taldone, T.,Chiosis, G.,Gewirth, D.T. Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity. Proteins, 87:869-877, 2019 Cited by PubMed: 31141217DOI: 10.1002/prot.25750 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55390799533 Å) |
Structure validation
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