3O2F

Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54

Summary for 3O2F

Entry DOI	10.2210/pdb3o2f/pdb
Related	2FWY 3O0I
Descriptor	Endoplasmin, 8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine, ISOPROPYL ALCOHOL, ... (5 entities in total)
Functional Keywords	hsp90 heat-shock proteins, chaperone-inhibitor complex, chaperone/inhibitor
Biological source	Canis lupus familiaris (dogs) More
Cellular location	Endoplasmic reticulum lumen: P41148
Total number of polymer chains	2
Total formula weight	54035.38
Authors	Seidler, P.M.,Gewirth, D.T. (deposition date: 2010-07-22, release date: 2011-10-05, Last modification date: 2024-02-21)
Primary citation	Patel, P.D.,Yan, P.,Seidler, P.M.,Patel, H.J.,Sun, W.,Yang, C.,Que, N.S.,Taldone, T.,Finotti, P.,Stephani, R.A.,Gewirth, D.T.,Chiosis, G. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat.Chem.Biol., 9:677-684, 2013 Cited by PubMed: 23995768 DOI: 10.1038/nchembio.1335 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation