3O2F
Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Endoplasmin | polymer | 236 | 26514.0 | 2 | UniProt (P41148) Pfam (PF13589) | Canis lupus familiaris (dogs) | Heat shock protein 90 kDa beta member 1, 94 kDa glucose-regulated protein, GRP-94 |
| 2 | C, I (A, B) | 8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine | non-polymer | 337.4 | 2 | Chemie (P54) | |||
| 3 | D, E, G, H (A) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 4 | Chemie (IPA) | |||
| 4 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A, B: 69 - 286 (UniProt: P41148)
A, B: 328 - 337 (UniProt: P41148)
| PDB | External Database | Details |
|---|---|---|
| Gly 65 | - | expression tag |
| Ser 66 | - | expression tag |
| His 67 | - | expression tag |
| Met 68 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 287 | - | linker |
| Gly 288 | - | linker |
| Gly 289 | - | linker |
| Gly 290 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53028.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1007.4 | |
| All* | Total formula weight | 54035.4 |
