3O0I
Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor PU-H54
Summary for 3O0I
Entry DOI | 10.2210/pdb3o0i/pdb |
Related | 3C11 |
Descriptor | HSP90AA1 protein, 8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine (3 entities in total) |
Functional Keywords | hsp90 heat-shock proteins, chaperone-inhibitor complex, chaperone/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 29110.59 |
Authors | Seidler, P.M.,Gewirth, D.T. (deposition date: 2010-07-19, release date: 2011-10-05, Last modification date: 2024-02-21) |
Primary citation | Patel, P.D.,Yan, P.,Seidler, P.M.,Patel, H.J.,Sun, W.,Yang, C.,Que, N.S.,Taldone, T.,Finotti, P.,Stephani, R.A.,Gewirth, D.T.,Chiosis, G. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat.Chem.Biol., 9:677-684, 2013 Cited by PubMed: 23995768DOI: 10.1038/nchembio.1335 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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