6OLX

Hsp90-alpha S52A bound to PU-11-trans

Summary for 6OLX

Entry DOI	10.2210/pdb6olx/pdb
Related	6N8W 6N8X 6N8Y
Descriptor	Heat shock protein HSP 90-alpha, 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine (3 entities in total)
Functional Keywords	hsp90, chaperone, cytosol, cancer, inhibitor, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29126.56
Authors	Gewirth, D.T.,Huck, J.D. (deposition date: 2019-04-17, release date: 2019-07-03, Last modification date: 2024-03-06)
Primary citation	Huck, J.D.,Que, N.L.S.,Sharma, S.,Taldone, T.,Chiosis, G.,Gewirth, D.T. Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity. Proteins, 87:869-877, 2019 Cited by PubMed: 31141217 DOI: 10.1002/prot.25750 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43760580022 Å)

Structure validation