5VYY

Structure of human Hsp90-alpha bound to resorcinylic inhibitor BnIm

Summary for 5VYY

Entry DOI	10.2210/pdb5vyy/pdb
Descriptor	Heat shock protein HSP 90-alpha, methyl 2-[2-(1-benzyl-1H-imidazol-2-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate, FORMIC ACID, ... (7 entities in total)
Functional Keywords	chaperone, chaperone-inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29361.39
Authors	Que, N.S.,Gewirth, D.T. (deposition date: 2017-05-26, release date: 2018-04-18, Last modification date: 2024-03-13)
Primary citation	Que, N.L.S.,Crowley, V.M.,Duerfeldt, A.S.,Zhao, J.,Kent, C.N.,Blagg, B.S.J.,Gewirth, D.T. Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding. J. Med. Chem., 61:2793-2805, 2018 Cited by PubMed: 29528635 DOI: 10.1021/acs.jmedchem.7b01608 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.792 Å)

Structure validation