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8RFB
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BU of 8rfb by Molmil
Cryo-EM structure of the R243C mutant of human Prolyl Endopeptidase-Like (PREPL) protein involved in Congenital myasthenic syndrome-22 (CMS22)
Descriptor: Prolyl endopeptidase-like
Authors:Theodoropoulou, A, Cavani, E, Antanasijevic, A, Marcaida, M.J, Dal Peraro, M.
Deposit date:2023-12-12
Release date:2024-09-04
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (4.01 Å)
Cite:Missense variants in CMS22 patients reveal that PREPL has both enzymatic and nonenzymatic functions.
JCI Insight, 9, 2024
2HZ8
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BU of 2hz8 by Molmil
QM/MM structure refined from NMR-structure of a single chain diiron protein
Descriptor: De novo designed diiron protein, ZINC ION
Authors:Calhoun, J.R, Liu, W, Spiegel, K, Dal Peraro, M, Klein, M.L, Wand, A.J, DeGrado, W.F.
Deposit date:2006-08-08
Release date:2007-07-17
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement.
Structure, 16, 2008
6QGS
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BU of 6qgs by Molmil
Crystal structure of APT1 bound to palmitic acid.
Descriptor: Acyl-protein thioesterase 1, CHLORIDE ION, PALMITIC ACID
Authors:Audagnotto, M, Marcaida, M.J, Ho, S, Pojer, F, Van der Goot, G, Dal Peraro, M.
Deposit date:2019-01-12
Release date:2020-02-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.755 Å)
Cite:Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
Nat.Chem.Biol., 2021
6QGQ
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BU of 6qgq by Molmil
Crystal structure of APT1 C2S mutant bound to palmitic acid.
Descriptor: Acyl-protein thioesterase 1, GLYCEROL, PALMITIC ACID
Authors:Audagnotto, M, Marcaida, M.J, Ho, S, Pojer, F, Van der Goot, G, Dal Peraro, M.
Deposit date:2019-01-12
Release date:2020-02-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
Nat.Chem.Biol., 2021
6QGN
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BU of 6qgn by Molmil
Crystal structure of APT1 bound to 2-Bromopalmitate
Descriptor: 2-Bromopalmitic acid, Acyl-protein thioesterase 1
Authors:Marcaida, M.J, Audagnotto, M, Ho, S, Pojer, F, Van der Goot, G, Dal Peraro, M.
Deposit date:2019-01-12
Release date:2020-02-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
Nat.Chem.Biol., 2021
6QGO
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BU of 6qgo by Molmil
Crystal structure of APT1 S119A mutant bound to palmitic acid.
Descriptor: Acyl-protein thioesterase 1, PALMITIC ACID
Authors:Audagnotto, M, Marcaida, M.J, Ho, S, Pojer, F, Van der Goot, G, Dal Peraro, M.
Deposit date:2019-01-12
Release date:2020-02-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.599 Å)
Cite:Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
Nat.Chem.Biol., 2021
9FNQ
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BU of 9fnq by Molmil
Aerolysin double mutant K238A/K244A in styrene-maleic acid lipid particles
Descriptor: Aerolysin
Authors:Anton, J.S, Bada Juarez, J.F, Marcaida, M.J, Dal Peraro, M.
Deposit date:2024-06-10
Release date:2025-02-12
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment.
J.Am.Chem.Soc., 147, 2025
9FM6
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BU of 9fm6 by Molmil
Aerolysin Wildtype in styrene-maleic acid lipid particles
Descriptor: Aerolysin
Authors:Anton, J.S, Bada Juarez, J.F, Marcaida, M.J, Dal Peraro, M.
Deposit date:2024-06-05
Release date:2025-02-12
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment.
J.Am.Chem.Soc., 147, 2025
9FNP
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BU of 9fnp by Molmil
Aerolysin mutant K238A in styrene-maleic acid lipid particles
Descriptor: Aerolysin
Authors:Anton, J.S, Bada Juarez, J.F, Marcaida, M.J, Dal Peraro, M.
Deposit date:2024-06-10
Release date:2025-02-12
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment.
J.Am.Chem.Soc., 147, 2025
5JZH
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BU of 5jzh by Molmil
Cryo-EM structure of aerolysin prepore
Descriptor: Aerolysin
Authors:Iacovache, I, Zuber, B.
Deposit date:2016-05-16
Release date:2016-07-13
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process.
Nat Commun, 7, 2016
7OBM
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BU of 7obm by Molmil
Crystal structure of the human Prolyl Endopeptidase-Like protein short form (residues 90-727)
Descriptor: Prolyl endopeptidase-like
Authors:Rosier, K, McDevitt, M.T, Brendan, J.F, Marcaida, M.J, Bingman, C.A, Pagliarini, D.J, Creemers, J.W.M, Smith, R.W, Mitochondrial Protein Partnership (MPP)
Deposit date:2021-04-22
Release date:2021-11-10
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function.
Iscience, 24, 2021
7SSP
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BU of 7ssp by Molmil
Structure of the human COQ7:COQ9 complex by single-particle electron cryo-microscopy, unliganded state
Descriptor: 5-demethoxyubiquinone hydroxylase, mitochondrial, Ubiquinone biosynthesis protein COQ9
Authors:Aydin, H, Frost, A.
Deposit date:2021-11-11
Release date:2022-11-02
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure and functionality of a multimeric human COQ7:COQ9 complex.
Mol.Cell, 82, 2022
7SSS
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BU of 7sss by Molmil
Structure of the NADH-bound human COQ7:COQ9 complex by single-particle electron cryo-microscopy
Descriptor: (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-[(2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAENYL]PHENOL, 5-demethoxyubiquinone hydroxylase, ...
Authors:Aydin, H, Frost, A.
Deposit date:2021-11-11
Release date:2022-11-02
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structure and functionality of a multimeric human COQ7:COQ9 complex.
Mol.Cell, 82, 2022
5I35
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BU of 5i35 by Molmil
Structure of the Human mitochondrial kinase COQ8A R611K with AMPPNP (Cerebellar Ataxia and Ubiquinone Deficiency Through Loss of Unorthodox Kinase Activity)
Descriptor: Atypical kinase ADCK3, mitochondrial, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Bingman, C.A, Stefely, J.A, Pagliarini, D.J, Mitochondrial Protein Partnership (MPP)
Deposit date:2016-02-09
Release date:2016-08-17
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.
Mol.Cell, 63, 2016
3G4O
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BU of 3g4o by Molmil
Crystal structure of the activated aerolysin mutant H132N
Descriptor: Aerolysin
Authors:Pernot, L, Schiltz, M, van der Goot, G.
Deposit date:2009-02-04
Release date:2010-02-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dual chaperone role of the C-terminal propeptide in folding and oligomerization of the pore-forming toxin aerolysin.
Plos Pathog., 7, 2011
3G4N
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BU of 3g4n by Molmil
Crystal structure of the activated aerolysin mutant H132D
Descriptor: Aerolysin
Authors:Pernot, L, Schiltz, M, van der Goot, G.
Deposit date:2009-02-04
Release date:2010-02-09
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Dual chaperone role of the C-terminal propeptide in folding and oligomerization of the pore-forming toxin aerolysin.
Plos Pathog., 7, 2011
6DEW
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BU of 6dew by Molmil
Structure of human COQ9 protein with bound isoprene.
Descriptor: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, (2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, (2Z,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, ...
Authors:Bingman, C.A, Lohman, D.C, Smith, R.W, Pagliarini, D.J.
Deposit date:2018-05-13
Release date:2019-02-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.
Mol.Cell, 73, 2019
6HX0
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BU of 6hx0 by Molmil
Cell wall binding domain of endolysin from Listeria phage A500.
Descriptor: L-alanyl-D-glutamate peptidase
Authors:Dunne, M, Taylor, N.M.I, Shen, Y, Loessner, M.J, Leiman, P.G.
Deposit date:2018-10-15
Release date:2019-10-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural basis for recognition of bacterial cell wall teichoic acid by pseudo-symmetric SH3b-like repeats of a viral peptidoglycan hydrolase
Chem Sci, 2020
6HTF
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BU of 6htf by Molmil
Crystal structure of human Btk SH2 domain bound to rF10 repebody
Descriptor: Tyrosine-protein kinase BTK, rF10 repebody
Authors:Duarte, D.P, Pojer, F, Hantschel, O.
Deposit date:2018-10-04
Release date:2020-05-20
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Nat Commun, 11, 2020
6AWL
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BU of 6awl by Molmil
Crystal structure of human Coq9
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, Ubiquinone biosynthesis protein COQ9, ...
Authors:Bingman, C.A, Lohman, D.C, Smith, R.W, Pagliarini, D.J, Mitochondrial Protein Partnership (MPP)
Deposit date:2017-09-05
Release date:2019-02-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.
Mol. Cell, 73, 2019
9CEA
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BU of 9cea by Molmil
Crystal structure of HP1alpha chromoshadow domain
Descriptor: Chromobox protein homolog 5
Authors:Selvam, K, Gaurav, N, Kutateladze, T.G.
Deposit date:2024-06-26
Release date:2025-06-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The HP1 box of KAP1 organizes HP1 alpha for silencing of endogenous retroviral elements in embryonic stem cells.
Nat Commun, 16, 2025
9CDW
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BU of 9cdw by Molmil
Crystal structure of HP1alpha chromoshadow domain in complex with KAP1 peptide
Descriptor: Chromobox protein homolog 5, TRIETHYLENE GLYCOL, Transcription intermediary factor 1-beta peptide
Authors:Selvam, K, Singh, R.K, Gaurav, N, Kutateladze, T.G.
Deposit date:2024-06-25
Release date:2025-06-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The HP1 box of KAP1 organizes HP1 alpha for silencing of endogenous retroviral elements in embryonic stem cells.
Nat Commun, 16, 2025
8PBV
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BU of 8pbv by Molmil
Solution NMR structure of D. melanogaster TotA
Descriptor: Protein Turandot A
Authors:Abriata, L.A.
Deposit date:2023-06-09
Release date:2024-04-17
Method:SOLUTION NMR
Cite:A humoral stress response protects Drosophila tissues from antimicrobial peptides.
Curr.Biol., 34, 2024
3C0N
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BU of 3c0n by Molmil
Crystal structure of the proaerolysin mutant Y221G at 2.2 A
Descriptor: Aerolysin
Authors:Pernot, L, Schiltz, M, Thurnheer, S, Burr, S.E, van der Goot, G.
Deposit date:2008-01-21
Release date:2008-02-12
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism.
Nat.Chem.Biol., 9, 2013
3C0O
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BU of 3c0o by Molmil
Crystal structure of the proaerolysin mutant Y221G complexed with mannose-6-phosphate
Descriptor: 6-O-phosphono-alpha-D-mannopyranose, ACETATE ION, Aerolysin
Authors:Pernot, L, Schiltz, M, Thurnheer, S, Burr, S.E, van der Goot, G.
Deposit date:2008-01-21
Release date:2008-02-12
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism.
Nat.Chem.Biol., 9, 2013

 

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