6QGO

Crystal structure of APT1 S119A mutant bound to palmitic acid.

Summary for 6QGO

• Entry DOI: 10.2210/pdb6qgo/pdb
• Related: 6QGN
• Descriptor: Acyl-protein thioesterase 1, PALMITIC ACID (3 entities in total)
• Functional Keywords: acyl-protein thioesterase, palmitic acid, depalmitoylation, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 50212.16

Authors

Audagnotto, M.,Marcaida, M.J.,Ho, S.,Pojer, F.,Van der Goot, G.,Dal Peraro, M. (deposition date: 2019-01-12, release date: 2020-02-05, Last modification date: 2024-01-24)

• Primary citation: Abrami, L.,Audagnotto, M.,Ho, S.,Marcaida, M.J.,Mesquita, F.S.,Anwar, M.U.,Sandoz, P.A.,Fonti, G.,Pojer, F.,Dal Peraro, M.,van der Goot, F.G.; Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.; Nat.Chem.Biol., 2021; PubMed: 33707782; DOI: 10.1038/s41589-021-00753-2

Experimental method

X-RAY DIFFRACTION (2.599 Å)