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6QGO

Crystal structure of APT1 S119A mutant bound to palmitic acid.

Functional Information from GO Data
ChainGOidnamespacecontents
B0002084biological_processprotein depalmitoylation
B0004620molecular_functionphospholipase activity
B0004622molecular_functionlysophospholipase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0008474molecular_functionpalmitoyl-(protein) hydrolase activity
B0015908biological_processfatty acid transport
B0016020cellular_componentmembrane
B0016298molecular_functionlipase activity
B0016787molecular_functionhydrolase activity
B0031965cellular_componentnuclear membrane
B0035973biological_processaggrephagy
B0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
B0070062cellular_componentextracellular exosome
B0071211biological_processprotein targeting to vacuole involved in autophagy
B1905336biological_processnegative regulation of aggrephagy
C0002084biological_processprotein depalmitoylation
C0004620molecular_functionphospholipase activity
C0004622molecular_functionlysophospholipase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006629biological_processlipid metabolic process
C0006631biological_processfatty acid metabolic process
C0008474molecular_functionpalmitoyl-(protein) hydrolase activity
C0015908biological_processfatty acid transport
C0016020cellular_componentmembrane
C0016298molecular_functionlipase activity
C0016787molecular_functionhydrolase activity
C0031965cellular_componentnuclear membrane
C0035973biological_processaggrephagy
C0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
C0070062cellular_componentextracellular exosome
C0071211biological_processprotein targeting to vacuole involved in autophagy
C1905336biological_processnegative regulation of aggrephagy
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue PLM B 301
ChainResidue
BLEU30
BHIS208
BLEU78
BPRO80
BALA119
BGLN120
BTRP145
BARG149
BPHE181
BTHR185

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Charge relay system => ECO:0000269|PubMed:19439193, ECO:0000269|PubMed:37802024
ChainResidueDetails
BALA119
CALA119

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Charge relay system => ECO:0000305|PubMed:11080636
ChainResidueDetails
BASP174
BHIS208
CASP174
CHIS208

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P97823
ChainResidueDetails
BLYS224
CLYS224

237423

PDB entries from 2025-06-11

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