6QGO

Crystal structure of APT1 S119A mutant bound to palmitic acid.

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002084	biological_process	protein depalmitoylation
B	0004620	molecular_function	phospholipase activity
B	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0008474	molecular_function	palmitoyl-(protein) hydrolase activity
B	0015908	biological_process	fatty acid transport
B	0016298	molecular_function	lipase activity
B	0016787	molecular_function	hydrolase activity
B	0031965	cellular_component	nuclear membrane
B	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
B	0070062	cellular_component	extracellular exosome
B	1905336	biological_process	negative regulation of aggrephagy
C	0002084	biological_process	protein depalmitoylation
C	0004620	molecular_function	phospholipase activity
C	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0008474	molecular_function	palmitoyl-(protein) hydrolase activity
C	0015908	biological_process	fatty acid transport
C	0016298	molecular_function	lipase activity
C	0016787	molecular_function	hydrolase activity
C	0031965	cellular_component	nuclear membrane
C	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
C	0070062	cellular_component	extracellular exosome
C	1905336	biological_process	negative regulation of aggrephagy

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue PLM B 301

Chain	Residue
B	LEU30
B	HIS208
B	LEU78
B	PRO80
B	ALA119
B	GLN120
B	TRP145
B	ARG149
B	PHE181
B	THR185

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19439193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37802024","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11080636","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P97823","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---