1LBU
 
 | | HYDROLASE METALLO (ZN) DD-PEPTIDASE | | Descriptor: | MURAMOYL-PENTAPEPTIDE CARBOXYPEPTIDASE, ZINC ION | | Authors: | Charlier, P, Wery, J.-P, Dideberg, O, Frere, J.-M. | | Deposit date: | 1996-03-16 | | Release date: | 1996-11-08 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Streptomyces Albus G D-Ala-A-Ala Carboxypeptidase
Handbook of Metalloproteins, 3, 2004
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3TVL
 | | Complex between the human thiamine triphosphatase and triphosphate | | Descriptor: | 1,2-ETHANEDIOL, TRIPHOSPHATE, Thiamine-triphosphatase | | Authors: | Delvaux, D, Herman, R, Sauvage, E, Wins, P, Bettendorff, L, Charlier, P, Kerff, F. | | Deposit date: | 2011-09-20 | | Release date: | 2012-10-10 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural determinants of specificity and catalytic mechanism in mammalian 25-kDa thiamine triphosphatase.
Biochim.Biophys.Acta, 1830, 2013
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4D2O
 | | Crystal structure of the class A extended-spectrum beta-lactamase PER- 2 | | Descriptor: | PER-2 BETA-LACTAMASE | | Authors: | Power, P, Herman, R, Ruggiero, M, Kerff, F, Galleni, M, Gutkind, G, Charlier, P, Sauvage, E. | | Deposit date: | 2014-05-12 | | Release date: | 2014-05-21 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal Structure of the Extended-Spectrum Beta-Lactamase Per- 2 and Insights Into the Role of Specific Residues in the Interaction with Beta-Lactams and Beta-Lactamase Inhibitors.
Antimicrob.Agents Chemother., 58, 2014
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6Y6L
 | | Structure the ananain protease from Ananas comosus with a thiomethylated catalytic cysteine | | Descriptor: | Ananain, GLYCEROL, SULFATE ION | | Authors: | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | | Deposit date: | 2020-02-26 | | Release date: | 2020-11-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Sci Rep, 10, 2020
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2X71
 | | Structural basis for the interaction of lactivicins with serine beta- lactamases | | Descriptor: | (2E)-2-{[(2S)-2-(ACETYLAMINO)-2-CARBOXYETHOXY]IMINO}PENTANEDIOIC ACID, BETA-LACTAMASE, ETHANOL, ... | | Authors: | Sauvage, E, Herman, R, Kerff, F, Rocaboy, M, Charlier, P. | | Deposit date: | 2010-02-22 | | Release date: | 2010-07-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Basis for the Interaction of Lactivicins with Serine Beta-Lactamases.
J.Med.Chem., 53, 2010
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2XLN
 | | Crystal structure of a complex between Actinomadura R39 DD-peptidase and a boronate inhibitor | | Descriptor: | COBALT (II) ION, D-ALANYL-D-ALANINE CARBOXYPEPTIDASE,, SULFATE ION, ... | | Authors: | Sauvage, E, Herman, R, Kerff, F, Rocaboy, M, Charlier, P. | | Deposit date: | 2010-07-21 | | Release date: | 2011-01-26 | | Last modified: | 2014-06-18 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors
Acs Med.Chem.Lett., 2, 2011
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2Y55
 | | Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein | | Descriptor: | ACETONE, D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, MAGNESIUM ION, ... | | Authors: | Sauvage, E, Zervosen, A, Herman, R, Kerff, F, Rocaboy, M, Charlier, P. | | Deposit date: | 2011-01-12 | | Release date: | 2011-07-27 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Unexpected Tricovalent Binding Mode of Boronic Acids within the Active Site of a Penicillin- Binding Protein.
J.Am.Chem.Soc., 133, 2011
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5AEB
 | | Crystal structure of the class B3 di-zinc metallo-beta-lactamase LRA- 12 from an Alaskan soil metagenome. | | Descriptor: | COBALT (II) ION, LRA-12, SULFATE ION, ... | | Authors: | Power, P, Herman, R, Kerff, F, Bouillenne, F, Rodriguez, M.M, Galleni, M, Handelsman, J, Gutkind, G, Charlier, P, Sauvage, E. | | Deposit date: | 2015-08-27 | | Release date: | 2015-09-16 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure and kinetic analysis of the class B3 di-zinc metallo-beta-lactamase LRA-12 from an Alaskan soil metagenome.
PLoS ONE, 12, 2017
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1SKF
 | | CRYSTAL STRUCTURE OF THE STREPTOMYCES K15 DD-TRANSPEPTIDASE | | Descriptor: | D-ALANYL-D-ALANINE TRANSPEPTIDASE | | Authors: | Fonze, E, Charlier, P. | | Deposit date: | 1998-08-20 | | Release date: | 1999-08-20 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure of a penicilloyl-serine transferase of intermediate penicillin sensitivity. The DD-transpeptidase of streptomyces K15.
J.Biol.Chem., 274, 1999
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1ES4
 | | C98N mutant of streptomyces K15 DD-transpeptidase | | Descriptor: | DD-TRANSPEPTIDASE | | Authors: | Fonze, E, Charlier, P. | | Deposit date: | 2000-04-07 | | Release date: | 2000-05-03 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis.
Biochemistry, 42, 2003
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1ES2
 | | S96A mutant of streptomyces K15 DD-transpeptidase | | Descriptor: | DD-TRANSPEPTIDASE | | Authors: | Fonze, E, Charlier, P. | | Deposit date: | 2000-04-07 | | Release date: | 2000-05-03 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis.
Biochemistry, 42, 2003
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1ES3
 | | C98A mutant of streptomyces K15 DD-transpeptidase | | Descriptor: | DD-TRANSPEPTIDASE, SODIUM ION | | Authors: | Fonze, E, Charlier, P. | | Deposit date: | 2000-04-07 | | Release date: | 2000-05-03 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis.
Biochemistry, 42, 2003
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1ESI
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1ES5
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3D30
 | | Structure of an expansin like protein from Bacillus Subtilis at 1.9A resolution | | Descriptor: | Expansin like protein, FORMIC ACID, GLYCEROL | | Authors: | Kerff, F, Petrella, S, Herman, R, Sauvage, E, Joris, B, Charlier, P. | | Deposit date: | 2008-05-09 | | Release date: | 2008-10-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization.
Proc.Natl.Acad.Sci.USA, 105, 2008
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7AP7
 | | Structure of the W64R amyloidogenic variant of human lysozyme | | Descriptor: | Lysozyme C, SULFATE ION | | Authors: | Vettore, N, Herman, R, Kerff, F, Charlier, P, Sauvage, E, Brans, A, Morray, J, Dobson, C, Kumita, J, Dumoulin, M. | | Deposit date: | 2020-10-16 | | Release date: | 2021-08-25 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Characterisation of the structural, dynamic and aggregation properties of the W64R amyloidogenic variant of human lysozyme.
Biophys.Chem., 271, 2021
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1J9M
 | | K38H mutant of Streptomyces K15 DD-transpeptidase | | Descriptor: | CHLORIDE ION, DD-transpeptidase, SODIUM ION | | Authors: | Fonze, E, Rhazi, N, Nguyen-Disteche, M, Charlier, P. | | Deposit date: | 2001-05-28 | | Release date: | 2001-06-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis.
Biochemistry, 42, 2003
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3D2Z
 | | Complex of the N-acetylmuramyl-L-alanine amidase AmiD from E.coli with the product L-Ala-D-gamma-Glu-L-Lys | | Descriptor: | CHLORIDE ION, L-Ala-D-gamma-Glu-L-Lys peptide, N-acetylmuramoyl-L-alanine amidase amiD, ... | | Authors: | Kerff, F, Petrella, S, Herman, R, Sauvage, E, Mercier, F, Luxen, A, Frere, J.M, Joris, B, Charlier, P. | | Deposit date: | 2008-05-09 | | Release date: | 2009-06-16 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Specific Structural Features of the N-Acetylmuramoyl-l-Alanine Amidase AmiD from Escherichia coli and Mechanistic Implications for Enzymes of This Family.
J.Mol.Biol., 397, 2010
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3D2Y
 | | Complex of the N-acetylmuramyl-L-alanine amidase AmiD from E.coli with the substrate anhydro-N-acetylmuramic acid-L-Ala-D-gamma-Glu-L-Lys | | Descriptor: | Anhydro-N-acetylmuramic acid-L-Ala-D-gamma-Glu-L-Lys, GLYCEROL, N-acetylmuramoyl-L-alanine amidase amiD | | Authors: | Kerff, F, Petrella, S, Herman, R, Sauvage, E, Mercier, F, Luxen, A, Frere, J.M, Joris, B, Charlier, P. | | Deposit date: | 2008-05-09 | | Release date: | 2009-06-16 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Specific Structural Features of the N-Acetylmuramoyl-l-Alanine Amidase AmiD from Escherichia coli and Mechanistic Implications for Enzymes of This Family.
J.Mol.Biol., 397, 2010
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4M3K
 | | Structure of a single domain camelid antibody fragment cAb-H7S in complex with the BlaP beta-lactamase from Bacillus licheniformis | | Descriptor: | Beta-lactamase, CHLORIDE ION, Camelid heavy-chain antibody variable fragment cAb-H7S | | Authors: | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | | Deposit date: | 2013-08-06 | | Release date: | 2014-08-06 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments
To be Published
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4M3J
 | | Structure of a single-domain camelid antibody fragment cAb-H7S specific of the BlaP beta-lactamase from Bacillus licheniformis | | Descriptor: | Camelid heavy-chain antibody variable fragment cAb-H7S, SULFATE ION | | Authors: | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | | Deposit date: | 2013-08-06 | | Release date: | 2014-08-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments
To be Published
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1BSG
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4N1H
 | | Structure of a single-domain camelid antibody fragment cAb-F11N in complex with the BlaP beta-lactamase from Bacillus licheniformis | | Descriptor: | Beta-lactamase, Camelid heavy-chain antibody variable fragment cAb-F11N | | Authors: | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | | Deposit date: | 2013-10-04 | | Release date: | 2014-10-08 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments
To be Published
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1I2S
 | | BETA-LACTAMASE FROM BACILLUS LICHENIFORMIS BS3 | | Descriptor: | BETA-LACTAMASE, CITRIC ACID, SODIUM ION | | Authors: | Fonze, E, Vanhove, M, Dive, G, Sauvage, E, Frere, J.M, Charlier, P. | | Deposit date: | 2001-02-12 | | Release date: | 2002-03-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of the Bacillus licheniformis BS3 class A beta-lactamase and of the
acyl-enzyme adduct formed with cefoxitin
Biochemistry, 41, 2002
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1I2W
 | | BETA-LACTAMASE FROM BACILLUS LICHENIFORMIS BS3 COMPLEXED WITH CEFOXITIN | | Descriptor: | (2R)-5-[(carbamoyloxy)methyl]-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, BETA-LACTAMASE, CARBAMIC ACID | | Authors: | Fonze, E, Vanhove, M, Dive, G, Sauvage, E, Frere, J.M, Charlier, P. | | Deposit date: | 2001-02-12 | | Release date: | 2002-03-13 | | Last modified: | 2018-09-12 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of the Bacillus licheniformis BS3 class A beta-lactamase and of the acyl-enzyme adduct formed with cefoxitin
Biochemistry, 41, 2002
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