1I2W

BETA-LACTAMASE FROM BACILLUS LICHENIFORMIS BS3 COMPLEXED WITH CEFOXITIN

Summary for 1I2W

• Entry DOI: 10.2210/pdb1i2w/pdb
• Related: 1I2S
• Descriptor: BETA-LACTAMASE, (2R)-5-[(carbamoyloxy)methyl]-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, CARBAMIC ACID, ... (4 entities in total)
• Functional Keywords: serine beta-lactamase, hydrolase, antibiotic resistance
• Biological source: Bacillus licheniformis
• Total number of polymer chains: 2
• Total formula weight: 63492.22

Authors

Fonze, E.,Vanhove, M.,Dive, G.,Sauvage, E.,Frere, J.M.,Charlier, P. (deposition date: 2001-02-12, release date: 2002-03-13, Last modification date: 2018-09-12)

• Primary citation: Fonze, E.,Vanhove, M.,Dive, G.,Sauvage, E.,Frere, J.M.,Charlier, P.; Crystal structures of the Bacillus licheniformis BS3 class A beta-lactamase and of the acyl-enzyme adduct formed with cefoxitin; Biochemistry, 41:1877-1885, 2002; PubMed: 11827533; DOI: 10.1021/bi015789k

Experimental method

X-RAY DIFFRACTION (1.7 Å)