Author results

1AV1
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CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN A-I
Descriptor:APOLIPOPROTEIN A-I
Authors:Borhani, D.W., Rogers, D.P., Engler, J.A., Brouillette, C.G.
Deposit date:1997-09-23
Release date:1998-02-04
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation.
Proc.Natl.Acad.Sci.USA, 94, 1997
2PZ8
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NAD+ SYNTHETASE FROM BACILLUS ANTHRACIS WITH AMP-CPP AND MG2+
Descriptor:NH(3)-dependent NAD(+) synthetase, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:McDonald, H.M., Pruett, P.S., Deivanayagam, C., Protasevich, I.I., Carson, W.M., DeLucas, L.J., Brouillette, W.J., Brouillette, C.G.
Deposit date:2007-05-17
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD(+) synthetase from Bacillus anthracis.
Acta Crystallogr.,Sect.D, 63, 2007
2PZA
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NAD+ SYNTHETASE FROM BACILLUS ANTHRACIS WITH AMP + PPI AND MG2+
Descriptor:NH(3)-dependent NAD(+) synthetase, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE, ...
Authors:McDonald, H.M., Pruett, P.S., Deivanayagam, C., Protasevich, I.I., Carson, W.M., DeLucas, L.J., Brouillette, W.J., Brouillette, C.G.
Deposit date:2007-05-17
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD(+) synthetase from Bacillus anthracis.
Acta Crystallogr.,Sect.D, 63, 2007
2PZB
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NAD+ SYNTHETASE FROM BACILLUS ANTHRACIS
Descriptor:NH(3)-dependent NAD(+) synthetase, SULFATE ION
Authors:McDonald, H.M., Pruett, P.S., Deivanayagam, C., Protasevich, I.I., Carson, W.M., DeLucas, L.J., Brouillette, W.J., Brouillette, C.G.
Deposit date:2007-05-17
Release date:2007-07-31
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD(+) synthetase from Bacillus anthracis.
Acta Crystallogr.,Sect.D, 63, 2007
3DV2
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CRYSTAL STRUCTURE OF NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE FROM BACILLUS ANTHRACIS
Descriptor:Nicotinate (Nicotinamide) nucleotide adenylyltransferase, SULFATE ION
Authors:Lu, S., Smith, C.D., Yang, Z., Pruett, P.S., Nagy, L., McCombs, D.P., DeLucas, L.J., Brouillette, W.J., Brouillette, C.G.
Deposit date:2008-07-18
Release date:2008-11-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis.
ACTA CRYSTALLOGR.,SECT.F, 64, 2008
1CDJ
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STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4
Descriptor:T-CELL SURFACE GLYCOPROTEIN CD4
Authors:Wu, H., Myszka, D., Tendian, S.W., Brouillette, C.G., Sweet, R.W., Chaiken, I.M., Hendrickson, W.A.
Deposit date:1996-11-11
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding.
Proc.Natl.Acad.Sci.USA, 93, 1996
1CDU
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STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4 MUTANT WITH PHE 43 REPLACED BY VAL
Descriptor:T-CELL SURFACE GLYCOPROTEIN CD4
Authors:Wu, H., Myszka, D., Tendian, S.W., Brouillette, C.G., Sweet, R.W., Chaiken, I.M., Hendrickson, W.A.
Deposit date:1996-11-11
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding.
Proc.Natl.Acad.Sci.USA, 93, 1996
1CDY
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STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4 MUTANT WITH GLY 47 REPLACED BY SER
Descriptor:T-CELL SURFACE GLYCOPROTEIN CD4
Authors:Wu, H., Myszka, D., Tendian, S.W., Brouillette, C.G., Sweet, R.W., Chaiken, I.M., Hendrickson, W.A.
Deposit date:1996-11-11
Release date:1997-04-01
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding.
Proc.Natl.Acad.Sci.USA, 93, 1996
5TF7
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NUCLEOTIDE-BINDING DOMAIN 1 OF THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH ATP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Wang, C., Aleksandrov, A.A., Yang, Z., Forouhar, F., Proctor, E., Kota, P., An, J., Kaplan, A., Khazanov, N., Boel, G., Stockwell, B.R., Senderowitz, H., Dokholyan, N.V., Riordan, J.R., Brouillette, C.G., Hunt, J.F.
Deposit date:2016-09-24
Release date:2018-05-09
Method:X-RAY DIFFRACTION (1.931 Å)
Cite:Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5TF8
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NUCLEOTIDE-BINDING DOMAIN 1 OF THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH DTTP
Descriptor:Cystic fibrosis transmembrane conductance regulator, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Wang, C., Aleksandrov, A.A., Yang, Z., Forouhar, F., Proctor, E., Kota, P., An, J., Kaplan, A., Khazanov, N., Boel, G., Stockwell, B.R., Senderowitz, H., Dokholyan, N.V., Riordan, J.R., Brouillette, C.G., Hunt, J.F.
Deposit date:2016-09-24
Release date:2018-05-09
Method:X-RAY DIFFRACTION (1.861 Å)
Cite:Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5TFA
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NUCLEOTIDE-BINDING DOMAIN 1 OF THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH DUTP
Descriptor:Cystic fibrosis transmembrane conductance regulator, DEOXYURIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Wang, C., Aleksandrov, A.A., Yang, Z., Forouhar, F., Proctor, E., Kota, P., An, J., Kaplan, A., Khazanov, N., Boel, G., Stockwell, B.R., Senderowitz, H., Dokholyan, N.V., Riordan, J.R., Brouillette, C.G., Hunt, J.F.
Deposit date:2016-09-24
Release date:2018-05-09
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5TFB
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NUCLEOTIDE-BINDING DOMAIN 1 OF THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH 7-METHYL-GTP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE
Authors:Wang, C., Aleksandrov, A.A., Yang, Z., Forouhar, F., Proctor, E., Kota, P., An, J., Kaplan, A., Khazanov, N., Boel, G., Stockwell, B.R., Senderowitz, H., Dokholyan, N.V., Riordan, J.R., Brouillette, C.G., Hunt, J.F.
Deposit date:2016-09-24
Release date:2018-05-09
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5TFC
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NUCLEOTIDE-BINDING DOMAIN 1 OF THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH GTP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Wang, C., Aleksandrov, A.A., Yang, Z., Forouhar, F., Proctor, E., Kota, P., An, J., Kaplan, A., Khazanov, N., Boel, G., Stockwell, B.R., Senderowitz, H., Dokholyan, N.V., Riordan, J.R., Brouillette, C.G., Hunt, J.F.
Deposit date:2016-09-24
Release date:2018-05-09
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5TFD
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NUCLEOTIDE-BINDING DOMAIN 1 OF THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH CTP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, CYTIDINE-5'-TRIPHOSPHATE
Authors:Wang, C., Aleksandrov, A.A., Yang, Z., Forouhar, F., Proctor, E., Kota, P., An, J., Kaplan, A., Khazanov, N., Boel, G., Stockwell, B.R., Senderowitz, H., Dokholyan, N.V., Riordan, J.R., Brouillette, C.G., Hunt, J.F.
Deposit date:2016-09-24
Release date:2018-05-09
Method:X-RAY DIFFRACTION (1.891 Å)
Cite:Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5TFF
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NUCLEOTIDE-BINDING DOMAIN 1 OF THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH UTP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, URIDINE 5'-TRIPHOSPHATE
Authors:Wang, C., Aleksandrov, A.A., Yang, Z., Forouhar, F., Proctor, E., Kota, P., An, J., Kaplan, A., Khazanov, N., Boel, G., Stockwell, B.R., Senderowitz, H., Dokholyan, N.V., Riordan, J.R., Brouillette, C.G., Hunt, J.F.
Deposit date:2016-09-25
Release date:2018-05-09
Method:X-RAY DIFFRACTION (1.891 Å)
Cite:Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5TFG
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NUCLEOTIDE-BINDING DOMAIN 1 OF THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH 5-METHYL-UTP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, 5-Methyluridine triphosphate
Authors:Wang, C., Aleksandrov, A.A., Yang, Z., Forouhar, F., Proctor, E., Kota, P., An, J., Kaplan, A., Khazanov, N., Boel, G., Stockwell, B.R., Senderowitz, H., Dokholyan, N.V., Riordan, J.R., Brouillette, C.G., Hunt, J.F.
Deposit date:2016-09-25
Release date:2018-05-09
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5TFI
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NUCLEOTIDE-BINDING DOMAIN 1 OF THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH DGTP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE
Authors:Wang, C., Aleksandrov, A.A., Yang, Z., Forouhar, F., Proctor, E., Kota, P., An, J., Kaplan, A., Khazanov, N., Boel, G., Stockwell, B.R., Senderowitz, H., Dokholyan, N.V., Riordan, J.R., Brouillette, C.G., Hunt, J.F.
Deposit date:2016-09-25
Release date:2018-05-09
Method:X-RAY DIFFRACTION (1.891 Å)
Cite:Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5TFJ
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NUCLEOTIDE-BINDING DOMAIN 1 OF THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH DCTP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE
Authors:Wang, C., Aleksandrov, A.A., Yang, Z., Forouhar, F., Proctor, E., Kota, P., An, J., Kaplan, A., Khazanov, N., Boel, G., Stockwell, B.R., Senderowitz, H., Dokholyan, N.V., Riordan, J.R., Brouillette, C.G., Hunt, J.F.
Deposit date:2016-09-25
Release date:2018-05-09
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published
5TGK
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NUCLEOTIDE-BINDING DOMAIN 1 OF THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH DATP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
Authors:Wang, C., Aleksandrov, A.A., Yang, Z., Forouhar, F., Proctor, E., Kota, P., An, J., Kaplan, A., Khazanov, N., Boel, G., Stockwell, B.R., Senderowitz, H., Dokholyan, N.V., Riordan, J.R., Brouillette, C.G., Hunt, J.F.
Deposit date:2016-09-28
Release date:2018-05-09
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.912 Å)
Cite:Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.
J. Biol. Chem., 2018
2PZE
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-17
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZF
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER WITH DELTA F508
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-18
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZG
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A MONOMER
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-18
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010