2PZE

Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer

Summary for 2PZE

Related1XMI 1XMJ 2BB0 2BBS 2BBT 1R0Z 1R10 2IXE 1L2T 1Q12 1XEF 2HYD 2PZF 2PZG
DescriptorCystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywordsnbd, abc transporter, cftr, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight52113.79
Authors
Atwell, S.,Conners, K.,Emtage, S.,Gheyi, T.,Glenn, N.R.,Hendle, J.,Lewis, H.A.,Lu, F.,Rodgers, L.A.,Romero, R.,Sauder, J.M.,Smith, D.,Tien, H.,Wasserman, S.R.,Zhao, X. (deposition date: 2007-05-17, release date: 2007-10-09, Last modification date: 2018-11-14)
Primary citation
Atwell, S.,Brouillette, C.G.,Conners, K.,Emtage, S.,Gheyi, T.,Guggino, W.B.,Hendle, J.,Hunt, J.F.,Lewis, H.A.,Lu, F.,Protasevich, I.I.,Rodgers, L.A.,Romero, R.,Wasserman, S.R.,Weber, P.C.,Wetmore, D.,Zhang, F.F.,Zhao, X.
Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23:375-384, 2010
PubMed: 20150177 (PDB entries with the same primary citation)
DOI: 10.1093/protein/gzq004
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers4 0.5% 1.7% 11.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 2pze
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Molmil generated image of 2pze
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Molmil generated image of 2pze
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2pze.pdb1.gz [39.21 KB])
Coordinate files for Biological unit (2pze.pdb2.gz [38.99 KB])