2PZE

Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cystic fibrosis transmembrane conductance regulator	polymer	229	25525.4	2	UniProt (P13569) Pfam (PF00005)	Homo sapiens (human)	CFTR, cAMP- dependent chloride channel, ATP-binding cassette transporter sub- family C member 7
2	C, E (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	D, F (A, B)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
4	G, H (A, B)	water	water		18.0	194	Chemie (HOH)

Sequence modifications

A, B: 387 - 404 (UniProt: P13569)

PDB	External Database	Details
Ser 386	-	expression tag

A, B: 437 - 646 (UniProt: P13569)

PDB	External Database	Details
Met 470	Val 470	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51050.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1063.0
All*	Total formula weight	52113.8

*Water molecules are not included.